接受锂和丙戊酸治疗的双相情感障碍患者的抗氧化状态以及硒、锌和砷浓度

IF 3.5 3区 医学 Q2 NEUROSCIENCES Frontiers in Molecular Neuroscience Pub Date : 2024-09-11 DOI:10.3389/fnmol.2024.1441575
Joanna Rog, Łukasz Łobejko, Michalina Hordejuk, Wojciech Marciniak, Róża Derkacz, Adam Kiljańczyk, Milena Matuszczak, Jan Lubiński, Miłosz Nesterowicz, Małgorzata Żendzian-Piotrowska, Anna Zalewska, Mateusz Maciejczyk, Hanna Karakula-Juchnowicz
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引用次数: 0

摘要

躁郁症(BD)的一个关键因素是原/抗氧化剂平衡失调。一些研究表明,治疗会影响躁郁症患者体内的微量元素浓度。本研究旨在利用机器学习算法分类和回归树(C&RT)分析,确定:(a)双相情感障碍中与氧化应激有关的变化及其与参与促/抗氧化平衡的微量元素之间的关系;(b)双相情感障碍生物标志物。研究纳入了 62 名 BD 患者和 40 名健康人(HC)。研究人员评估了血液中促/抗氧化状态的浓度以及硒、锌、砷的浓度。我们发现,与健康人相比,BD 患者的总抗氧化能力、过氧化氢酶、高级氧化蛋白产物的浓度较高,而 4-羟基壬烯醛(4-HNE)、谷胱甘肽、谷胱甘肽过氧化物酶(GPx)的浓度较低。与 HC 组相比,BD 组的所有受检微量元素均较低。4-HNE(临界值:≤ 0.004 uM/mg蛋白)和谷胱甘肽过氧化物酶(临界值:≤ 0.485 U/mg蛋白)这两个变量的组合是最有希望区分BD和HC的标志物。C&RT的接收者工作特征曲线下面积值为90.5%。BD患者原/抗氧化状态的紊乱和微量元素的浓度可能是BD生物标志物新的治疗或诊断机会的目标。
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Pro/antioxidant status and selenium, zinc and arsenic concentration in patients with bipolar disorder treated with lithium and valproic acid
Disturbances in pro/antioxidant balance emerge as a crucial element in bipolar disorder (BD). Some studies suggest that treatment effects on trace element concentration in BD. This study aimed to identify (a) the changes related to oxidative stress in BD and their relationship with trace elements engaged in pro/antioxidant homeostasis; (b) BD biomarkers using machine learning algorithm classification and regression tree (C&RT) analysis. 62 individuals with BD and 40 healthy individuals (HC) were included in the study. The concentration of pro/antioxidant state and concentration of selenium, zinc, arsenic in blood were assessed. We found a higher concentration of total antioxidant capacity, catalase, advanced oxidation protein products and a lower concentration of 4-hydroxynonenal (4-HNE), glutathione, glutathione peroxidase (GPx) in BD compared to HC. All examined trace elements were lower in the BD group compared to HC. A combination of two variables, 4-HNE (cut-off: ≤ 0.004 uM/mg protein) and GPx (cut-off: ≤ 0.485 U/mg protein), was the most promising markers for separating the BD from the HC. The area under the receiver operating characteristic curve values for C&RT was 90.5%. Disturbances in the pro/antioxidant state and concentration of trace elements of patients with BD may be a target for new therapeutic or diagnostic opportunity of BD biomarkers.
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来源期刊
CiteScore
5.70
自引率
2.10%
发文量
669
审稿时长
14 weeks
期刊介绍: Frontiers in Molecular Neuroscience is a first-tier electronic journal devoted to identifying key molecules, as well as their functions and interactions, that underlie the structure, design and function of the brain across all levels. The scope of our journal encompasses synaptic and cellular proteins, coding and non-coding RNA, and molecular mechanisms regulating cellular and dendritic RNA translation. In recent years, a plethora of new cellular and synaptic players have been identified from reduced systems, such as neuronal cultures, but the relevance of these molecules in terms of cellular and synaptic function and plasticity in the living brain and its circuits has not been validated. The effects of spine growth and density observed using gene products identified from in vitro work are frequently not reproduced in vivo. Our journal is particularly interested in studies on genetically engineered model organisms (C. elegans, Drosophila, mouse), in which alterations in key molecules underlying cellular and synaptic function and plasticity produce defined anatomical, physiological and behavioral changes. In the mouse, genetic alterations limited to particular neural circuits (olfactory bulb, motor cortex, cortical layers, hippocampal subfields, cerebellum), preferably regulated in time and on demand, are of special interest, as they sidestep potential compensatory developmental effects.
期刊最新文献
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