TRPV1 在外周神经病理性疼痛中的双重作用:致敏或脱敏引起的疼痛开关

IF 3.5 3区 医学 Q2 NEUROSCIENCES Frontiers in Molecular Neuroscience Pub Date : 2024-09-09 DOI:10.3389/fnmol.2024.1400118
Ning Gao, Meng Li, Weiming Wang, Zhen Liu, Yufeng Guo
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引用次数: 0

摘要

瞬时受体电位类香草素 1(TRPV1)通道在外周神经病理性疼痛(NeuP)中扮演着双重角色,通过敏化和脱敏充当 "疼痛开关"。组织损伤或炎症通常会导致痛觉过敏,这涉及到 TRPV1 通道的敏化,而 TRPV1 通道会调节从初级传入痛觉感受器到脊髓背角神经元的感觉传导。在化疗诱发的周围神经病变(CIPN)中,TRPV1 与离子通道、神经递质信号转导和氧化应激相互作用,因而与神经病理性疼痛机制有关。背根神经节神经元中 TRPV1 的敏化有助于 CIPN 的发展,抑制 TRPV1 通道可降低化疗引起的机械过敏性。在糖尿病周围神经病变(DPN)中,TRPV1 通过活性氧和细胞因子产生等途径参与疼痛调节。TRPV1 与 TRPA1 通道的相互作用进一步影响了慢性疼痛的发生和发展。在治疗方面,TRPV1 激动剂辣椒素可通过受体脱敏诱导镇痛,而 TRPV1 拮抗剂和靶向 TRPV1 的 siRNA 则在临床前研究中大有可为。大麻素对TRPV1的调节为缓解神经病理性疼痛提供了另一种潜在途径。本综述总结了有关 TRPV1 与外周神经痛相关的最新临床前研究。
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The dual role of TRPV1 in peripheral neuropathic pain: pain switches caused by its sensitization or desensitization
The transient receptor potential vanilloid 1 (TRPV1) channel plays a dual role in peripheral neuropathic pain (NeuP) by acting as a “pain switch” through its sensitization and desensitization. Hyperalgesia, commonly resulting from tissue injury or inflammation, involves the sensitization of TRPV1 channels, which modulates sensory transmission from primary afferent nociceptors to spinal dorsal horn neurons. In chemotherapy-induced peripheral neuropathy (CIPN), TRPV1 is implicated in neuropathic pain mechanisms due to its interaction with ion channels, neurotransmitter signaling, and oxidative stress. Sensitization of TRPV1 in dorsal root ganglion neurons contributes to CIPN development, and inhibition of TRPV1 channels can reduce chemotherapy-induced mechanical hypersensitivity. In diabetic peripheral neuropathy (DPN), TRPV1 is involved in pain modulation through pathways including reactive oxygen species and cytokine production. TRPV1’s interaction with TRPA1 channels further influences chronic pain onset and progression. Therapeutically, capsaicin, a TRPV1 agonist, can induce analgesia through receptor desensitization, while TRPV1 antagonists and siRNA targeting TRPV1 show promise in preclinical studies. Cannabinoid modulation of TRPV1 provides another potential pathway for alleviating neuropathic pain. This review summarizes recent preclinical research on TRPV1 in association with peripheral NeuP.
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来源期刊
CiteScore
5.70
自引率
2.10%
发文量
669
审稿时长
14 weeks
期刊介绍: Frontiers in Molecular Neuroscience is a first-tier electronic journal devoted to identifying key molecules, as well as their functions and interactions, that underlie the structure, design and function of the brain across all levels. The scope of our journal encompasses synaptic and cellular proteins, coding and non-coding RNA, and molecular mechanisms regulating cellular and dendritic RNA translation. In recent years, a plethora of new cellular and synaptic players have been identified from reduced systems, such as neuronal cultures, but the relevance of these molecules in terms of cellular and synaptic function and plasticity in the living brain and its circuits has not been validated. The effects of spine growth and density observed using gene products identified from in vitro work are frequently not reproduced in vivo. Our journal is particularly interested in studies on genetically engineered model organisms (C. elegans, Drosophila, mouse), in which alterations in key molecules underlying cellular and synaptic function and plasticity produce defined anatomical, physiological and behavioral changes. In the mouse, genetic alterations limited to particular neural circuits (olfactory bulb, motor cortex, cortical layers, hippocampal subfields, cerebellum), preferably regulated in time and on demand, are of special interest, as they sidestep potential compensatory developmental effects.
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