用于引导骨再生的基于壳聚糖/明胶/介孔生物活性玻璃纳米颗粒的多功能不对称双层薄膜的制备与表征

IF 2.7 4区 材料科学 Q3 MATERIALS SCIENCE, MULTIDISCIPLINARY Journal of Materials Research Pub Date : 2024-08-26 DOI:10.1557/s43578-024-01414-5
Muhammad Asim Akhtar, Jan Novak, Christian Radwansky, Aldo. R. Boccaccini
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摘要

利用生物聚合物和介孔生物活性玻璃纳米颗粒(MBGNs)的组合,通过电泳沉积(EPD)制造了双面 GBR 膜。膜的设计旨在充分利用生物聚合物和 MBGNs 的优势特性。致密复合层由含有 MBGNs 的壳聚糖(CS)组成,并被植物治疗药物柚皮苷(Nar)功能化。多孔层由 CS-明胶(Gel)-MBGNs 以及铜螯合壳聚糖(Cu(II)-CS)-Gel-MBGNs 复合材料组成。EPD 以直流模式进行。结果表明,由于 Cu(II) 和 Nar 的存在,膜具有抗菌活性。在用 MC3T3-E1(前成骨细胞)和 MG-63(类成骨细胞)细胞系进行测试时,薄膜具有细胞相容性。不过,释放出的 Cu(II) 离子有轻微的细胞毒性作用。相比之下,Nar 负载薄膜的细胞存活率有所提高。这些结果表明,EPD 在为 GBR 应用制造双层结构方面具有很大的潜力。
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Fabrication and characterization of multifunctional, asymmetric bilayer films based on chitosan/gelatin/mesoporous bioactive glass nanoparticles for guided bone regeneration

Two-faced GBR membranes were fabricated by electrophoretic deposition (EPD) using a combination of biopolymers and mesoporous bioactive glass nanoparticles (MBGNs). The membrane design was aimed at leveraging the advantageous properties of both biopolymers and MBGNs. The dense composite layer consisted of chitosan (CS) incorporating MBGNs and it was functionalized with a phytotherapeutic drug, naringin (Nar). The porous layer consisted of CS-gelatin (Gel)- MBGNs as well as copper chelated chitosan (Cu(II)-CS)-Gel-MBGNs composites. EPD was conducted in direct current mode. The antibacterial activity of the membranes as a result of the presence of Cu(II) and Nar was confirmed. The films were cytocompatible when tested with MC3T3-E1 (pre-osteoblastic) and MG-63 (osteoblast like) cell lines. However, a slight cytotoxic effect of the releasing Cu(II) ions was determined. In contrast, Nar-loaded films revealed improved cell viability. The results indicate the high potential of EPD to fabricate bilayer structures for GBR applications.

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来源期刊
Journal of Materials Research
Journal of Materials Research 工程技术-材料科学:综合
CiteScore
4.50
自引率
3.70%
发文量
362
审稿时长
2.8 months
期刊介绍: Journal of Materials Research (JMR) publishes the latest advances about the creation of new materials and materials with novel functionalities, fundamental understanding of processes that control the response of materials, and development of materials with significant performance improvements relative to state of the art materials. JMR welcomes papers that highlight novel processing techniques, the application and development of new analytical tools, and interpretation of fundamental materials science to achieve enhanced materials properties and uses. Materials research papers in the following topical areas are welcome. • Novel materials discovery • Electronic, photonic and magnetic materials • Energy Conversion and storage materials • New thermal and structural materials • Soft materials • Biomaterials and related topics • Nanoscale science and technology • Advances in materials characterization methods and techniques • Computational materials science, modeling and theory
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