TMSOTf 催化亚酰胺与炔基硫醚的环化反应，构建取代的马来酰亚胺类化合物

IF 2.8 4区化学 Q1 CHEMISTRY, ORGANIC Asian Journal of Organic Chemistry Pub Date : 2024-09-09 DOI:10.1002/ajoc.202400416

Nanfang Wang, Wozheng Fang, Yu Yan, Nan Sun, Junbiao Chang, Xiao-Na Wang

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引用次数: 0

摘要

本研究开发了一种 TMSOTf 催化的环化反应，利用氧作为绿色氧化剂，并利用亚酰胺作为碳源和氮源，从亚酰胺和炔基硫醚构建多取代马来酰亚胺。这种新方案在 TMSOTf 存在下进行，不需要昂贵的催化系统，而且耐受底物范围广，在温和的反应条件下，可提供各种马来酰亚胺，收率一般为中等到良好。

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TMSOTf‐Catalyzed Annulation of Ynamides with Alkynyl Sulfoxides to Construct Substituted Maleimides

A TMSOTf‐catalyzed annulation was developed for the construction of polysubstituted maleimides from ynamides and alkynyl sulfoxides, using oxygen as a green oxidant and ynamides as both carbon and nitrogen sources. This novel protocol proceeds in the presence of TMSOTf without the need for an expensive catalytic system and tolerates a broad substrate scope, providing a variety of maleimides in generally moderate to good yields under mild reaction conditions.

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来源期刊

Asian Journal of Organic Chemistry CHEMISTRY, ORGANIC-

CiteScore

4.70

自引率

3.70%

发文量

372

期刊介绍： Organic chemistry is the fundamental science that stands at the heart of chemistry, biology, and materials science. Research in these areas is vigorous and truly international, with three major regions making almost equal contributions: America, Europe and Asia. Asia now has its own top international organic chemistry journal—the Asian Journal of Organic Chemistry (AsianJOC) The AsianJOC is designed to be a top-ranked international research journal and publishes primary research as well as critical secondary information from authors across the world. The journal covers organic chemistry in its entirety. Authors and readers come from academia, the chemical industry, and government laboratories.