通过双官能团过氧化物在碱诱导下合成异铬螺吡唑酮类化合物

IF 2.8 4区 化学 Q1 CHEMISTRY, ORGANIC Asian Journal of Organic Chemistry Pub Date : 2024-09-03 DOI:10.1002/ajoc.202400438
jiaxu feng, Xiangdi Wang, Yingying Wu
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引用次数: 0

摘要

异苯并吡喃是一种功能强大的支架,具有多种重要的生物活性。在此,我们介绍了通过 [1+5] 环化将双官能团过氧化物和吡唑酮合成有价值的异苯并吡喃螺吡唑酮的新型多功能方法。该方法是一种新颖的螺二苯并呋喃合成方案,具有良好的官能团兼容性、温和的条件和易于获得的底物等特点。
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Base induced synthesis of isochroman spiropyrazolones via bifunctional peroxides
Isochroman is one of the powerful scaffolds which demonstrated various important biologically activities. Herein we represented the novel and versatile method for the synthesis of valuable isochroman spiropyrazolones of difunctional peroxides and pyrazolones via [1+5] annulation. This process represents a novel spiroisocchroman synthesis protocol and is featured by good functional group compatibility, mild conditions and readily available substrates.
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来源期刊
CiteScore
4.70
自引率
3.70%
发文量
372
期刊介绍: Organic chemistry is the fundamental science that stands at the heart of chemistry, biology, and materials science. Research in these areas is vigorous and truly international, with three major regions making almost equal contributions: America, Europe and Asia. Asia now has its own top international organic chemistry journal—the Asian Journal of Organic Chemistry (AsianJOC) The AsianJOC is designed to be a top-ranked international research journal and publishes primary research as well as critical secondary information from authors across the world. The journal covers organic chemistry in its entirety. Authors and readers come from academia, the chemical industry, and government laboratories.
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