用于非活性烯官能化的巯基-烯偶联反应:油酸甲酯胺化化学实验研究

IF 2.8 4区 化学 Q1 CHEMISTRY, ORGANIC Asian Journal of Organic Chemistry Pub Date : 2024-09-03 DOI:10.1002/ajoc.202400334
Mara L. Polo, David A. Echeverri, Laureana Soria, Victoria A. Vaillard, Gregorio Meira, Santiago E. Vaillard, Luis A. Ríos, Diana Estenoz
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引用次数: 0

摘要

这项研究探讨了通过硫醇-烯偶联(TEC)反应对具有非活化内双键的分子进行官能化的问题。对半胱胺盐酸盐(CAHC)和油酸甲酯(MO)之间的反应进行了全面研究。在不同的操作条件下进行了一系列反应,以评估它们对转化率和选择性的影响。考虑了不同的条件,如气氛和溶剂类型、CAHC 的部分添加、试剂浓度和 CAHC 的过量。在惰性气氛、稀释条件、乙醇作为溶剂以及在反应开始时加入 CAHC(CAHC/MO 的摩尔比为 3/1)的情况下,转化率和选择性达到最高。这为分析更复杂的反应体系提供了一种方法。
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THIOL‐ENE COUPLING REACTION FOR FUNCTIONALIZATION OF NON‐ACTIVATED ALKENES: AN EXPERIMENTAL STUDY ON THE CHEMISTRY OF THE METHYL OLEATE AMINATION
This work investigates the functionalization of molecules with non‐activated internal double bonds via thiol‐ene coupling (TEC) reaction. A comprehensive study of the reaction between cysteamine hydrochloride (CAHC) and methyl oleate (MO) was carried out. A series of reactions were conducted under different operating conditions in order to assess their effect on conversion and selectivity. Different conditions were considered like the type of atmospheres and solvents, a portionwise addition of CAHC, reagents concentrations, and excess of CAHC. Maximum conversion and selectivity were reached under inert atmosphere, diluted conditions, ethanol as solvent, and the addition of CAHC at the beginning of the reaction with a molar ratio of CAHC/MO of 3/1. This provides an approach for analyzing more complex reaction systems..
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来源期刊
CiteScore
4.70
自引率
3.70%
发文量
372
期刊介绍: Organic chemistry is the fundamental science that stands at the heart of chemistry, biology, and materials science. Research in these areas is vigorous and truly international, with three major regions making almost equal contributions: America, Europe and Asia. Asia now has its own top international organic chemistry journal—the Asian Journal of Organic Chemistry (AsianJOC) The AsianJOC is designed to be a top-ranked international research journal and publishes primary research as well as critical secondary information from authors across the world. The journal covers organic chemistry in its entirety. Authors and readers come from academia, the chemical industry, and government laboratories.
期刊最新文献
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