{"title":"棕色脂肪组织的无创代谢成像","authors":"Jean Nakhle","doi":"10.1038/s41592-024-02422-3","DOIUrl":null,"url":null,"abstract":"","PeriodicalId":18981,"journal":{"name":"Nature Methods","volume":null,"pages":null},"PeriodicalIF":36.1000,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Non-invasive metabolic imaging of brown adipose tissue\",\"authors\":\"Jean Nakhle\",\"doi\":\"10.1038/s41592-024-02422-3\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"\",\"PeriodicalId\":18981,\"journal\":{\"name\":\"Nature Methods\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":36.1000,\"publicationDate\":\"2024-09-10\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nature Methods\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://www.nature.com/articles/s41592-024-02422-3\",\"RegionNum\":1,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"BIOCHEMICAL RESEARCH METHODS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature Methods","FirstCategoryId":"99","ListUrlMain":"https://www.nature.com/articles/s41592-024-02422-3","RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"BIOCHEMICAL RESEARCH METHODS","Score":null,"Total":0}
引用次数: 0
摘要
伊利诺伊大学芝加哥分校和中国南方医科大学附属广东省人民医院在蔡克佳和刘再义的领导下开展了一项合作研究项目，探索使用肌酸化学交换饱和转移（Cr-CEST）磁共振成像（MRI）作为一种无创和功能性 BAT 成像的方法。Cr-CEST 磁共振成像利用了肌酸与水交换胍质子的特性。Cr-CEST MRI 在注射了 β3-肾上腺素能受体激动剂或去甲肾上腺素的大鼠以及暴露在寒冷环境中的大鼠身上进行了测试。这些发现与传统的 BAT 检测方法，如[18F]氟脱氧葡萄糖（[18F]FDG）正电子发射断层扫描（PET）和计算机断层扫描（CT）进行了验证。研究还证实了Cr-CEST MRI对人体的适用性，证明了它在检测寒冷诱导的BAT激活以及划定BAT和周围白色脂肪组织之间的界限方面的有效性。
期刊介绍：
Nature Methods is a monthly journal that focuses on publishing innovative methods and substantial enhancements to fundamental life sciences research techniques. Geared towards a diverse, interdisciplinary readership of researchers in academia and industry engaged in laboratory work, the journal offers new tools for research and emphasizes the immediate practical significance of the featured work. It publishes primary research papers and reviews recent technical and methodological advancements, with a particular interest in primary methods papers relevant to the biological and biomedical sciences. This includes methods rooted in chemistry with practical applications for studying biological problems.
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