亲水相互作用液相色谱法在不同极性色谱柱上保留 N-亚硝基二乙醇胺:机理研究与优化

IF 2.2 4区 化学 Q3 CHEMISTRY, MULTIDISCIPLINARY Journal of the Iranian Chemical Society Pub Date : 2024-09-10 DOI:10.1007/s13738-024-03085-9
Ghazaleh Abedi, Zahra Talebpour, Arezu Hosseiny
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摘要

为研究N-亚硝基二乙醇胺(NDELA)在液相色谱中的保留机理,改变了硅胶、二元醇、氰基、氨基和齐聚物等5种固定相的流动相组成。随后,研究了温度、pH 值和缓冲液浓度的影响。结果表明,亲水相互作用液相色谱(HILIC)和反相色谱(RP)是保留玖龙牌萘乙二胺的双重机制。在不同的色谱柱上观察到 HILIC 和 RP 行为之间的转换,即 "U-turn "点,水在乙腈中的含量为 43% 至 68%。氰基、氨基和齐聚物色谱柱的保留因子自然对数与绝对温度的倒数呈线性关系。相反,硅胶柱和二元醇柱的保留因子呈曲线变化。在每种色谱柱中,正斜率表示负的保留焓,表明分析物从流动相转移到固定相的放热过程。在缓冲液 pH 值和浓度方面,选择了 pH 值为 5.7、浓度为 10 mM 的醋酸铵溶液进行进一步研究。最后,研究了该方法在最佳条件下分析洗发水中 NDELA 的选择性。根据洗发水中 NDELA 的良好选择性和 HILIC 方法的优点,该方法似乎可以替代 RP 方法。
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Retention of the N-nitrosodiethanolamine by hydrophilic interaction liquid chromatography on different polar columns: mechanism study and optimization

To investigate the retention mechanism of N-nitrosodiethanolamine (NDELA) in liquid chromatography, the mobile phase composition was changed on five stationary phases including silica, diol, cyano, amino, and zwitterionic. Afterward, temperature, pH, and buffer concentration effects are studied. Results demonstrate a dual hydrophilic interaction liquid chromatography (HILIC)-reversed phase (RP) mechanism for the retention of NDELA. The transition between the HILIC and RP behavior on a different column, “U-turn” points, was observed between 43 and 68% of water in acetonitrile. The depiction of the natural logarithm of retention factor vs. inverse of the absolute temperature was linear for cyano, amino, and zwitterionic columns. In contrast, it was curvature for silica and diol columns. In each column, the positive slopes indicate a negative retention enthalpy, signifying an exothermic process of transferring analytes from the mobile phase to the stationary phases being examined. In the case of buffer pH and concentration, an ammonium acetate solution with a pH of 5.7 and a concentration of 10 mM was selected for further investigation. Finally, the selectivity of this method in optimal conditions for the analysis of NDELA in shampoo has been investigated. According to the well-obtained selectivity of NDELA in shampoo and the advantages of the HILIC method, this method seems to be a suitable alternative to RP methods.

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来源期刊
CiteScore
4.40
自引率
8.30%
发文量
230
审稿时长
5.6 months
期刊介绍: JICS is an international journal covering general fields of chemistry. JICS welcomes high quality original papers in English dealing with experimental, theoretical and applied research related to all branches of chemistry. These include the fields of analytical, inorganic, organic and physical chemistry as well as the chemical biology area. Review articles discussing specific areas of chemistry of current chemical or biological importance are also published. JICS ensures visibility of your research results to a worldwide audience in science. You are kindly invited to submit your manuscript to the Editor-in-Chief or Regional Editor. All contributions in the form of original papers or short communications will be peer reviewed and published free of charge after acceptance.
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