{"title":"碳 11 标记甲氧苄啶的合成、放射性标记和临床前生物分布","authors":"Pardeep Kumar, Aishwarya Kumar, Deeksha Muralidhar, Pralay mallik, Pratap Chandra Acharya","doi":"10.1007/s10967-024-09758-2","DOIUrl":null,"url":null,"abstract":"<p>In this study, we have labeled methacetin with carbon-11 [<sup>11</sup>C] as a PET imaging radiotracer. The radiolabeling was carried out by reacting acetaminophen with [<sup>11</sup>C]methyl iodide in the presence of a base using [<sup>11</sup>C]methyl iodide. [<sup>11</sup>C]methacetin was synthesized via methylation at 70 °C for 5 min with a radiochemical purity of 99.3 ± 0.4 % and radiochemical yield was 34.6 ± 4.7 %. The tissue distribution showed higher uptake in blood pool at 5 min followed by increased uptake in lungs, liver and spleen.</p>","PeriodicalId":661,"journal":{"name":"Journal of Radioanalytical and Nuclear Chemistry","volume":null,"pages":null},"PeriodicalIF":1.5000,"publicationDate":"2024-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Synthesis, radiolabeling and preclinical biodistribution of carbon-11 labeled methacetin\",\"authors\":\"Pardeep Kumar, Aishwarya Kumar, Deeksha Muralidhar, Pralay mallik, Pratap Chandra Acharya\",\"doi\":\"10.1007/s10967-024-09758-2\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>In this study, we have labeled methacetin with carbon-11 [<sup>11</sup>C] as a PET imaging radiotracer. The radiolabeling was carried out by reacting acetaminophen with [<sup>11</sup>C]methyl iodide in the presence of a base using [<sup>11</sup>C]methyl iodide. [<sup>11</sup>C]methacetin was synthesized via methylation at 70 °C for 5 min with a radiochemical purity of 99.3 ± 0.4 % and radiochemical yield was 34.6 ± 4.7 %. The tissue distribution showed higher uptake in blood pool at 5 min followed by increased uptake in lungs, liver and spleen.</p>\",\"PeriodicalId\":661,\"journal\":{\"name\":\"Journal of Radioanalytical and Nuclear Chemistry\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":1.5000,\"publicationDate\":\"2024-09-13\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Radioanalytical and Nuclear Chemistry\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://doi.org/10.1007/s10967-024-09758-2\",\"RegionNum\":3,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CHEMISTRY, ANALYTICAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Radioanalytical and Nuclear Chemistry","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1007/s10967-024-09758-2","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, ANALYTICAL","Score":null,"Total":0}
Synthesis, radiolabeling and preclinical biodistribution of carbon-11 labeled methacetin
In this study, we have labeled methacetin with carbon-11 [11C] as a PET imaging radiotracer. The radiolabeling was carried out by reacting acetaminophen with [11C]methyl iodide in the presence of a base using [11C]methyl iodide. [11C]methacetin was synthesized via methylation at 70 °C for 5 min with a radiochemical purity of 99.3 ± 0.4 % and radiochemical yield was 34.6 ± 4.7 %. The tissue distribution showed higher uptake in blood pool at 5 min followed by increased uptake in lungs, liver and spleen.
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An international periodical publishing original papers, letters, review papers and short communications on nuclear chemistry. The subjects covered include: Nuclear chemistry, Radiochemistry, Radiation chemistry, Radiobiological chemistry, Environmental radiochemistry, Production and control of radioisotopes and labelled compounds, Nuclear power plant chemistry, Nuclear fuel chemistry, Radioanalytical chemistry, Radiation detection and measurement, Nuclear instrumentation and automation, etc.
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