外阴阴道念珠菌病是热带地区妇女日益沉重的负担,奇旺省巴拉特布尔医院就诊的妇女患有此病

IF 2.2 4区 医学 Q3 MYCOLOGY Journal de mycologie medicale Pub Date : 2024-09-03 DOI:10.1016/j.mycmed.2024.101509
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引用次数: 0

摘要

外阴阴道念珠菌病是一种酵母菌感染,通常由念珠菌在外阴和阴道内及周围过度生长引起。阴道分泌物异常、瘙痒和刺激感、阴道部位红肿、性交疼痛和排便困难是感染的重要临床表现。目前,阴道炎已成为已婚妇女日益沉重的负担之一。此外,抗真菌念珠菌的感染也给疾病的治疗带来了挑战。因此,本研究旨在确定引起外阴阴道念珠菌病的不同念珠菌种类,并确定其对不同抗真菌药物的敏感性模式。从 2022 年 9 月至 2023 年 3 月,在奇旺巴拉特布尔医院妇产科对有症状的已婚妇女进行了为期六个月的医院横断面定量研究。共有 300 个有症状的病例被纳入研究。研究人员按照标准微生物学程序从阴道拭子中分离出念珠菌,并使用不同的抗真菌剂进行抗真菌药敏试验。结果发现,外阴阴道念珠菌病的总发病率为 37.3%(112/300)。在不同的分离株中,白色念珠菌占多数(52.6%),其次是非白色念珠菌中的光滑念珠菌(29.3%)。25-35 岁年龄组的女性感染率更高(47.3%),使用避孕药具与外阴阴道念珠菌病之间的关系具有统计学意义(p <0.05)。念珠菌对两性霉素-B(68.1%)的敏感性较高,其次是氟康唑(Diflucan)和克霉唑(50.9%)。而对伏立康唑(27.6%)和伊曲康唑(35.30%)的敏感性最低。与非白色念珠菌相比,白色念珠菌对不同抗真菌药物的敏感性更高。由非白色念珠菌引起的阴道念珠菌病发病率不断上升,表明有必要对念珠菌进行常规分类。
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Vulvovaginal candidiasis, an increasing burden to women in the tropical regions attending Bharatpur Hospital, Chitwan

Vulvovaginal candidiasis is a yeast infection commonly caused by the overgrowth of Candida species in and around the vulva and vagina. Abnormal vaginal discharge, itching and irritation, swelling and redness of the vaginal area, pain during sexual intercourse, and dyspareunia are important clinical findings of the infection. Currently, the infection is one of the growing burdens to married women. Moreover, the infection with antifungal-resistant Candida species adds challenges to managing the disease. Hence, this study was conducted to identify the different Candida species causing vulvovaginal candidiasis and to determine its susceptibility pattern against different antifungal drugs. A hospital-based cross-sectional and quantitative study was conducted for the period of six months from September 2022 to March 2023 among symptomatic married women in the Gynecology and Obstetrics Department of Bharatpur Hospital, Chitwan. A total of 300 symptomatic cases were enrolled in the study. Candida species were isolated from vaginal swabs following standard microbiological procedures and antifungal susceptibility testing was performed with different antifungal agents. The total prevalence of vulvovaginal candidiasis was found to be 37.3 % (112/300). Among different isolates, Candida albicans was found to be the most predominant (52.6 %), followed by Candida glabrata (29.3 %) among non-albicans. Women from the age group 25–35 years were found to be more infected (47.3 %) and the relationship between contraceptive use and vulvovaginal candidiasis was found to be statistically significant (p < 0.05). Candida species showed higher susceptibility toward Amphotericin-B (68.1 %), followed by fluconazole (Diflucan), and Clotrimazole (50.9 %). Whereas the least susceptibility was observed to Voriconazole (27.6 %) and Itraconazole (35.30 %). Candida albicans was comparatively more susceptible to different antifungal drugs than non-albicans species. Candida parapsilosis was only susceptible to Amphotericin-B and the increasing incidence of vaginal candidiasis due to non-albicans Candida indicates the need for routine speciation of Candida.

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来源期刊
CiteScore
5.10
自引率
2.80%
发文量
68
审稿时长
6-12 weeks
期刊介绍: The Journal de Mycologie Medicale / Journal of Medical Mycology (JMM) publishes in English works dealing with human and animal mycology. The subjects treated are focused in particular on clinical, diagnostic, epidemiological, immunological, medical, pathological, preventive or therapeutic aspects of mycoses. Also covered are basic aspects linked primarily with morphology (electronic and photonic microscopy), physiology, biochemistry, cellular and molecular biology, immunochemistry, genetics, taxonomy or phylogeny of pathogenic or opportunistic fungi and actinomycetes in humans or animals. Studies of natural products showing inhibitory activity against pathogenic fungi cannot be considered without chemical characterization and identification of the compounds responsible for the inhibitory activity. JMM publishes (guest) editorials, original articles, reviews (and minireviews), case reports, technical notes, letters to the editor and information. Only clinical cases with real originality (new species, new clinical present action, new geographical localization, etc.), and fully documented (identification methods, results, etc.), will be considered. Under no circumstances does the journal guarantee publication before the editorial board makes its final decision. The journal is indexed in the main international databases and is accessible worldwide through the ScienceDirect and ClinicalKey platforms.
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