皮下脂肪组织放射密度：严重 COVID-19 的新风险因素

IF 3.2 3区医学 Q2 NUTRITION & DIETETICS Nutrition Pub Date : 2024-08-20 DOI:10.1016/j.nut.2024.112561

Daniela M.H. Padilha M.D. , Maria C.S. Mendes R.D., Ph.D. , Maria E.S. Takahashi Ph.D. , Fabiana Lascala R.D., M.Sc. , Marina N. Silveira R.D., Ph.D. , Lara Pozzuto R.D., M.Sc. , Larissa A.O. Carrilho R.D., M.Sc. , Lívia D. Guerra R.D. , Rafaella C.L. Moreira R.D., M.Sc. , Sandra R. Branbilla B.Sc. , Celso Darío Ramos M.D., Ph.D. , José B.C. Carvalheira M.D., Ph.D.

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引用次数: 0

摘要

背景脂肪组织放射性密度和代谢活动可能会影响 COVID-19 的预后。本研究评估了 COVID-19 患者脂肪组织特征与临床预后之间的关系。通过计算机断层扫描评估了皮下脂肪组织放射性密度（SATR）和内脏脂肪组织放射性密度。氟-18标记的氟脱氧葡萄糖PET/计算机断层扫描测量了脂肪组织的代谢活动。结果高 SATR 与死亡率风险增加（OR：2.70；P = 0.033）、住院时间更长（P <0.001）、机械通气率更高（P = 0.007）以及并发症：急性肾损伤（P = 0.001）、继发感染（P = 0.007）、休克（P = 0.010）和肺栓塞（P = 0.011）。SATR 与 SAT 葡萄糖摄取量呈正相关（ρ = 0.52），与瘦素水平呈负相关（ρ = -0.48）。SATR是急性和慢性炎症的潜在预后生物标志物。

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Subcutaneous adipose tissue radiodensity: An emerging risk factor for severe COVID-19

Background

Adipose tissue radiodensity and metabolic activity may influence COVID-19 outcomes. This study evaluated the association between adipose tissue characteristics and clinical outcomes in COVID-19 patients.

Methods

Two retrospective cohorts of hospitalized COVID-19 patients were analyzed. Subcutaneous adipose tissue radiodensity (SATR) and visceral adipose tissue radiodensity were assessed by computed tomography. Fluorine-18-labelled fluorodeoxyglucose PET/computed tomography measured adipose tissue metabolic activity. Associations with mortality, length of stay, ventilation requirement, and complications were examined using regression analyses.

Results

High SATR was independently associated with increased mortality risk (OR: 2.70; P = 0.033), longer hospitalization (P < 0.001), higher rates of mechanical ventilation (P = 0.007), and complications: acute kidney injury (P = 0.001), secondary infection (P = 0.007), shock (P = 0.010), and pulmonary embolism (P = 0.011). SATR positively correlated with SAT glucose uptake (ρ = 0.52) and negatively with leptin levels (ρ = –0.48).

Conclusions

Elevated SATR at COVID-19 diagnosis predicts disease severity and worse outcomes. SATR is a potential prognostic biomarker for acute and chronic inflammatory conditions.

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来源期刊

Nutrition 医学-营养学

CiteScore

7.80

自引率

2.30%

发文量

300

审稿时长

60 days

期刊介绍： Nutrition has an open access mirror journal Nutrition: X, sharing the same aims and scope, editorial team, submission system and rigorous peer review. Founded by Michael M. Meguid in the early 1980''s, Nutrition presents advances in nutrition research and science, informs its readers on new and advancing technologies and data in clinical nutrition practice, encourages the application of outcomes research and meta-analyses to problems in patient-related nutrition; and seeks to help clarify and set the research, policy and practice agenda for nutrition science to enhance human well-being in the years ahead.