静脉注射γ-羟丁酸镇静荷斯坦-弗里斯兰犊牛的剂量滴定法

IF 2.3 2区 农林科学 Q1 VETERINARY SCIENCES Veterinary journal Pub Date : 2024-09-12 DOI:10.1016/j.tvjl.2024.106246
C. Cuypers , B. Alonso , M. Devreese , S. Schauvliege
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引用次数: 0

摘要

γ-羟丁酸(GHB)是一种短链脂肪酸,可提供安全、持久的镇静效果,对心肺功能的影响极小。这项初步试验以 10 头三周大的荷斯坦-弗里斯兰雄性小牛为对象,研究了 5 分钟内静脉注射 GHB 的效果,剂量分别为 100 毫克/千克(G100,2 头)、150 毫克/千克(G150,4 头)或 200 毫克/千克(G200,4 头)。实现侧卧后,每隔 15 分钟监测镇静深度(范围:0 = 无镇静到 3 = 明显镇静)和对有害刺激的反应(范围:0 = 强烈到 3 = 无反应)、心率(HR)、呼吸频率(RR)、平均动脉压(MAP)和动脉血气的评分,直至胸骨复位。记录从给药结束到侧卧位和恢复胸骨位/站立位的时间。剂量 G100 可导致轻度镇静和共济失调,但无褥疮。剂量 G150 和 G200 分别导致侧卧时间为 8 ± 2 分钟和 9 ± 3 分钟,持续时间分别为 189 ± 41 分钟和 283 ± 29 分钟,镇静的总体中位数(范围)分别为 3(1-3)分和 3(2-3)分,对有害刺激的反应分别为 0(0-3)分和 0(0-3)分。心率(HR)的平均值(±SD)分别为 110 ± 10 和 106 ± 11 bpm;血压(MAP)分别为 87 ± 9 和 94 ± 5 mmHg;心率(RR)分别为 28 ± 5 和 26 ± 5 bpm。在这两个剂量率下,动脉血氧分压(PaO2)的平均值(±SD)分别为 74 ± 6 和 74 ± 2 mmHg,而动脉血二氧化碳氧分压(PaCO2)分别为 53 ± 3 和 47 ± 0.8 mmHg。根据这些初步结果,我们得出结论:GHB 有可能用作小牛的长效镇静剂。还需要进一步的研究来证实这一点。
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Dose titration of intravenously administered gamma-hydroxybutyric acid for sedation in Holstein-Friesian calves

Gamma-hydroxybutyric acid (GHB) is a short-chain fatty acid that can potentially provide safe, prolonged sedation with minimal cardiorespiratory effects. This preliminary trial, performed in 10 three-week-old male Holstein-Friesian calves, investigated the effects of GHB administered intravenously over 5 min at a dose of 100 (G100, n=2), 150 (G150, n=4) or 200 mg/kg (G200, n=4). Once lateral recumbency was achieved, scores for sedation depth (range: 0 = no sedation to 3 = marked) and response to noxious stimulation (range: 0 = strong to 3 = absent), heart rate (HR), respiratory rate (RR), mean arterial pressure (MAP) and arterial blood gases were monitored every 15 min until sternal recumbency. Times from end of administration to lateral recumbency and return to sternal/standing positions were recorded. Dose G100 resulted in mild sedation and ataxia without decubitus. Doses G150 and G200 respectively resulted in time to lateral recumbency 8 ± 2 and 9 ± 3 min, lasting 189 ± 41 and 283 ± 29 min, while overall median (range) scores for sedation were 3 (1−3) and 3 (2−3) respectively and response to noxious stimulation 0 (0−3) and 0 (0−3) respectively. The mean ± SD for HR was 110 ± 10 and 106 ± 11 bpm respectively; for MAP 87±9 and 94±5 mmHg respectively; and for RR 28 ± 5 and 26 ± 5 bpm respectively. The mean ± SD for arterial partial pressure of oxygen (PaO2) at these two dose rates was 74 ± 6 and 74 ± 2 mmHg respectively, while the arterial partial pressure of carbon dioxide oxygen (PaCO2) was 53 ± 3 and 47 ± 0.8 mmHg respectively. Based on these preliminary results we conclude that GHB has the potential to be used as a long-acting sedative in calves. Further studies are needed to confirm this.

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来源期刊
Veterinary journal
Veterinary journal 农林科学-兽医学
CiteScore
4.10
自引率
4.50%
发文量
79
审稿时长
40 days
期刊介绍: The Veterinary Journal (established 1875) publishes worldwide contributions on all aspects of veterinary science and its related subjects. It provides regular book reviews and a short communications section. The journal regularly commissions topical reviews and commentaries on features of major importance. Research areas include infectious diseases, applied biochemistry, parasitology, endocrinology, microbiology, immunology, pathology, pharmacology, physiology, molecular biology, immunogenetics, surgery, ophthalmology, dermatology and oncology.
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