{"title":"揭示阿尔茨海默病的真相:高选择性荧光探针的最新进展","authors":"","doi":"10.1016/j.ccr.2024.216221","DOIUrl":null,"url":null,"abstract":"<div><p>Alzheimer's disease (AD) is the predominant neurodegenerative disorder, affecting approximately 60–80 % of all patients diagnosed with dementia globally. Given the intricate nature of AD's pathogenesis, numerous biologically active substances have gained attention, including amyloid-β plaques (Aβ), TAU proteins, metal ions, and reactive oxygen/nitrogen/sulfur species. The development of small-molecule fluorescent probes targeting these molecules has emerged as a promising avenue for the diagnosis and treatment of AD. Despite significant progress, challenges remain in the field of AD-related fluorescent probes. One such challenge is achieving high selectivity and sensitivity towards the target biomolecules amidst the complex biological milieu. Furthermore, further investigation is required to address the probe stability, bioavailability, and biocompatibility issues in order to guarantee their efficacy in clinical applications. It is imperative that further innovation be pursued in the design and synthesis of fluorescent probes that are specifically tailored to AD. The integration of advanced imaging techniques, such as fluorescence imaging, may enhance the sensitivity and spatial resolution of these probes, facilitating early diagnosis and monitoring of disease progression. This review presents a systematic examination of the multifunctional fluorescent probes developed over the last five years, highlighting their structures, properties, and applications in targeted diagnosis and imaging of AD. 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引用次数: 0
摘要
阿尔茨海默病(AD)是最主要的神经退行性疾病,全球约有 60%-80% 的痴呆症患者受到该病的影响。由于阿尔茨海默病的发病机制错综复杂,许多生物活性物质受到关注,其中包括淀粉样β斑块(Aβ)、TAU 蛋白、金属离子和活性氧/氮/硫物种。针对这些分子的小分子荧光探针的开发已成为诊断和治疗注意力缺失症的一条很有前景的途径。尽管取得了重大进展,但 AD 相关荧光探针领域仍面临挑战。其中一个挑战就是在复杂的生物环境中实现对目标生物分子的高选择性和高灵敏度。此外,还需要进一步研究探针的稳定性、生物利用度和生物相容性等问题,以保证其在临床应用中的有效性。当务之急是进一步创新设计和合成专门针对 AD 的荧光探针。先进成像技术(如荧光成像)的整合可提高这些探针的灵敏度和空间分辨率,从而促进疾病的早期诊断和进展监测。本综述系统研究了过去五年中开发的多功能荧光探针,重点介绍了它们的结构、特性以及在AD靶向诊断和成像中的应用。通过阐明探针的设计原理和作用机制,我们希望深入了解它们在艾滋病临床研究中的潜在应用。
Shedding light on Alzheimer's disease: Recent advances in highly selective fluorescent probes
Alzheimer's disease (AD) is the predominant neurodegenerative disorder, affecting approximately 60–80 % of all patients diagnosed with dementia globally. Given the intricate nature of AD's pathogenesis, numerous biologically active substances have gained attention, including amyloid-β plaques (Aβ), TAU proteins, metal ions, and reactive oxygen/nitrogen/sulfur species. The development of small-molecule fluorescent probes targeting these molecules has emerged as a promising avenue for the diagnosis and treatment of AD. Despite significant progress, challenges remain in the field of AD-related fluorescent probes. One such challenge is achieving high selectivity and sensitivity towards the target biomolecules amidst the complex biological milieu. Furthermore, further investigation is required to address the probe stability, bioavailability, and biocompatibility issues in order to guarantee their efficacy in clinical applications. It is imperative that further innovation be pursued in the design and synthesis of fluorescent probes that are specifically tailored to AD. The integration of advanced imaging techniques, such as fluorescence imaging, may enhance the sensitivity and spatial resolution of these probes, facilitating early diagnosis and monitoring of disease progression. This review presents a systematic examination of the multifunctional fluorescent probes developed over the last five years, highlighting their structures, properties, and applications in targeted diagnosis and imaging of AD. By elucidating the probe design principles and mechanisms of action, we aim to provide insights into their potential applications in clinical research on AD.
期刊介绍:
Coordination Chemistry Reviews offers rapid publication of review articles on current and significant topics in coordination chemistry, encompassing organometallic, supramolecular, theoretical, and bioinorganic chemistry. It also covers catalysis, materials chemistry, and metal-organic frameworks from a coordination chemistry perspective. Reviews summarize recent developments or discuss specific techniques, welcoming contributions from both established and emerging researchers.
The journal releases special issues on timely subjects, including those featuring contributions from specific regions or conferences. Occasional full-length book articles are also featured. Additionally, special volumes cover annual reviews of main group chemistry, transition metal group chemistry, and organometallic chemistry. These comprehensive reviews are vital resources for those engaged in coordination chemistry, further establishing Coordination Chemistry Reviews as a hub for insightful surveys in inorganic and physical inorganic chemistry.