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IF 12.5 1区医学 Q1 CELL BIOLOGY Ageing Research Reviews Pub Date : 2024-09-12 DOI:10.1016/j.arr.2024.102489

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引用次数: 0

摘要

中风对全球健康影响深远，死亡率和发病率都很高。脑卒中可由脑缺血、脑出血（ICH）和蛛网膜下腔出血（SAH）引起。中风的病理生理学包括继发性损伤和不可逆的神经元功能丧失。翻译后修饰（PTM）已被认为是缺血性和出血性中风诱发脑损伤的关键调节机制。这些 PTM 包括磷酸化、糖基化、泛素化、SUMOylation、乙酰化和琥珀酰化。本综述深入探讨了与脑缺血、ICH 和 SAH 相关的神经炎症和神经元死亡的 PTMs 图谱的最新研究。本综述旨在解释 PTMs 在调节病理机制中的作用，并介绍鉴定 PTMs 的关键技术和蛋白质组学策略。这些知识有助于我们理解卒中损伤和修复过程的内在机制，从而制定创新的治疗策略。重要的是，本综述强调了探索 PTMs 对理解中风病理生理学的重要意义。

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Unraveling the protein post-translational modification landscape: Neuroinflammation and neuronal death after stroke

The impact of stroke on global health is profound, with both high mortality and morbidity rates. This condition can result from cerebral ischemia, intracerebral hemorrhage (ICH), and subarachnoid hemorrhage (SAH). The pathophysiology of stroke involves secondary damage and irreversible loss of neuronal function. Post-translational modifications (PTMs) have been recognized as crucial regulatory mechanisms in ischemic and hemorrhagic stroke-induced brain injury. These PTMs include phosphorylation, glycosylation, ubiquitination, SUMOylation, acetylation, and succinylation. This comprehensive review delves into recent research on the PTMs landscape associated with neuroinflammation and neuronal death specific to cerebral ischemia, ICH, and SAH. This review aims to explain the role of PTMs in regulating pathologic mechanisms and present critical techniques and proteomic strategies for identifying PTMs. This knowledge helps us comprehend the underlying mechanisms of stroke injury and repair processes, leading to the development of innovative treatment strategies. Importantly, this review underscores the significance of exploring PTMs to understand the pathophysiology of stroke.

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来源期刊

Ageing Research Reviews 医学-老年医学

CiteScore

19.80

自引率

2.30%

发文量

216

审稿时长

55 days

期刊介绍： With the rise in average human life expectancy, the impact of ageing and age-related diseases on our society has become increasingly significant. Ageing research is now a focal point for numerous laboratories, encompassing leaders in genetics, molecular and cellular biology, biochemistry, and behavior. Ageing Research Reviews (ARR) serves as a cornerstone in this field, addressing emerging trends. ARR aims to fill a substantial gap by providing critical reviews and viewpoints on evolving discoveries concerning the mechanisms of ageing and age-related diseases. The rapid progress in understanding the mechanisms controlling cellular proliferation, differentiation, and survival is unveiling new insights into the regulation of ageing. From telomerase to stem cells, and from energy to oxyradical metabolism, we are witnessing an exciting era in the multidisciplinary field of ageing research. The journal explores the cellular and molecular foundations of interventions that extend lifespan, such as caloric restriction. It identifies the underpinnings of manipulations that extend lifespan, shedding light on novel approaches for preventing age-related diseases. ARR publishes articles on focused topics selected from the expansive field of ageing research, with a particular emphasis on the cellular and molecular mechanisms of the aging process. This includes age-related diseases like cancer, cardiovascular disease, diabetes, and neurodegenerative disorders. The journal also covers applications of basic ageing research to lifespan extension and disease prevention, offering a comprehensive platform for advancing our understanding of this critical field.