兔子颈椎间盘退变模型及针灸疗法机理的探索性研究

IF 2.3 2区 农林科学 Q1 VETERINARY SCIENCES Veterinary journal Pub Date : 2024-09-11 DOI:10.1016/j.tvjl.2024.106244
Wei Liu , Qianyu Jia , Haidong Pang , Bo Kang , Jiahao Lin
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引用次数: 0

摘要

针灸是传统中医治疗椎间盘退变(IVDD)的重要治疗方法,应用范围广泛。它以中兽医理论为基础,结合病程阶段和个体差异进行辨证论治。然而,针灸治疗兔子颈椎间盘退变(CDD)的研究却很少。辨证论治是中兽医治疗的基本原则。外治法的穴位选择应以个体病因病机为基础。然而,目前大多数研究并未遵循这一原则。本研究结合西医对颈椎病发病机理的认识,从抗炎、镇痛、组织修复等方面入手,选取颈椎的交趾、风池、天柱、直肠、大椎、后溪等主穴,建立了CDD模型,并探讨了针刺治疗缓解家兔CDD的机理。磁共振成像(MRI)证实了兔 CDD 模型的成功建立。针灸刺激降低了 CDD 引起的兔子颈部平均温度和最高温度的升高。针刺治疗缓解了家兔颈部的椎间盘损伤,同时降低了促凋亡因子 Bax 的表达水平,提高了抗凋亡因子 Bcl-2 的表达水平。此外,针灸还能缓解家兔椎间盘的异常凋亡,降低TNF-α、IL-1β、IL-2、PGE2α等炎症因子的表达水平,减轻CDD引起的强烈炎症反应和疼痛反应。总之,针灸治疗可以通过调节炎症反应和椎间盘组织的异常凋亡来减缓家兔的 CDD。
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An exploratory study of cervical disc degeneration model and mechanism of acupuncture therapy in rabbits

Acupuncture is an important therapy method in traditional Chinese medicine for treating intervertebral disc degeneration (IVDD), offering a wide range of applications. It is based on the theory of Chinese veterinary medicine and combines the stage of the disease course and individual differences for syndrome differentiation and treatment. However, there are few studies on the acupuncture treatment of cervical disc degeneration (CDD) in rabbits. Treatment based on syndrome differentiation is the basic principle of Chinese veterinary treatment. The selection of acupoints for external treatment should be based on individual etiology and pathogenesis. Nevertheless, most current studies do not follow this guideline. In this study, we established the CDD model and explored the mechanism of acupuncture treatment in alleviating CDD in rabbits by selecting a group of main acupoints including cervical Jiaji, Fengchi, Tianzhu, Naohu, Dazhui, and Houxi acupoints, combined with Western medicine's understanding of the pathogenesis of cervical spondylosis, from the anti-inflammatory, analgesic, and tissue-repairing perspectives. Magnetic resonance imaging (MRI) confirmed the successful establishment of the rabbit CDD model. Acupuncture stimulation reduced the increase of average and maximum neck temperature due to CDD in rabbits. The acupuncture treatment relieved the spinal disc damage in the neck of the rabbit, which also decreased the expression level of pro-apoptotic factor Bax and increased the expression level of anti-apoptotic factor Bcl-2. In addition, it can alleviate the abnormal apoptosis of rabbit intervertebral disc, decrease the expression level of inflammatory factors such as TNF-α, IL-1β, IL-2, and PGE2α, and alleviate the intense inflammation and pain response caused by CDD in rabbits. In conclusion, Acupuncture treatment can slow down the CDD of rabbits by regulating the inflammatory response and abnormal apoptosis of intervertebral disc tissue.

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来源期刊
Veterinary journal
Veterinary journal 农林科学-兽医学
CiteScore
4.10
自引率
4.50%
发文量
79
审稿时长
40 days
期刊介绍: The Veterinary Journal (established 1875) publishes worldwide contributions on all aspects of veterinary science and its related subjects. It provides regular book reviews and a short communications section. The journal regularly commissions topical reviews and commentaries on features of major importance. Research areas include infectious diseases, applied biochemistry, parasitology, endocrinology, microbiology, immunology, pathology, pharmacology, physiology, molecular biology, immunogenetics, surgery, ophthalmology, dermatology and oncology.
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