扩大的血管周围空间负担预示着认知和功能表现的下降

IF 3.6 3区医学 Q1 CLINICAL NEUROLOGY Journal of the Neurological Sciences Pub Date : 2024-09-12 DOI:10.1016/j.jns.2024.123232

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引用次数: 0

摘要

方法83名居住在社区的老年人（56-86岁）每年完成三次认知评估，包括临床痴呆评级（CDR®）痴呆分期工具方框总和（CDR-SB）以及执行功能和外显记忆的综合测量。基线核磁共振扫描用于计算基底节和半脑中心的 ePVS。混合效应模型以 ePVS 为预测变量，认知测量为因变量。协变量包括年龄、性别、教育程度、脑小血管疾病（cSVD）风险因素和cSVD神经影像生物标志物。结果基线时，基底节ePVS计数高与执行功能评分和外显记忆评分低相关。此外，基底节ePVS基线预示着研究期间CDR-SB的纵向评分会变差。

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Enlarged perivascular space burden predicts declines in cognitive and functional performance

Introduction

We evaluated the relationship between baseline enlarged perivascular space (ePVS) burden and later cognitive decline.

Methods

83 community-dwelling, older adults (aged 56–86) completed three annual cognitive assessments that included the Clinical Dementia Rating (CDR®) Dementia Staging Instrument Sum of Boxes (CDR-SB) and composite measures of executive function and episodic memory. An MRI scan at baseline was used to count ePVS in the basal ganglia and centrum semiovale. Mixed effects models were run with ePVS as the predictor variable and cognitive measures as the dependent variable. Covariates included age, sex, education, cerebral small vessel disease (cSVD) risk factors, and cSVD neuroimaging biomarkers.

Results

At baseline, high basal ganglia ePVS counts were associated with lower executive function scores and episodic memory scores. Moreover, baseline basal ganglia ePVS predicted worse longitudinal CDR-SB scores over the study period.

Discussion

Basal ganglia ePVS burden is a promising biomarker for cSVD-related cognitive and functional decline.

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来源期刊

Journal of the Neurological Sciences 医学-临床神经学

CiteScore

7.60

自引率

2.30%

发文量

313

审稿时长

22 days

期刊介绍： The Journal of the Neurological Sciences provides a medium for the prompt publication of original articles in neurology and neuroscience from around the world. JNS places special emphasis on articles that: 1) provide guidance to clinicians around the world (Best Practices, Global Neurology); 2) report cutting-edge science related to neurology (Basic and Translational Sciences); 3) educate readers about relevant and practical clinical outcomes in neurology (Outcomes Research); and 4) summarize or editorialize the current state of the literature (Reviews, Commentaries, and Editorials). JNS accepts most types of manuscripts for consideration including original research papers, short communications, reviews, book reviews, letters to the Editor, opinions and editorials. Topics considered will be from neurology-related fields that are of interest to practicing physicians around the world. Examples include neuromuscular diseases, demyelination, atrophies, dementia, neoplasms, infections, epilepsies, disturbances of consciousness, stroke and cerebral circulation, growth and development, plasticity and intermediary metabolism.