Management of Human Papilloma Virus-Related Cervical and Gynaecological Pathogenesis Using Herbal Medicine, Meta Analysis

Introduction

Human papillomavirus (HPV) is a major cause of cervical cancer, particularly types 16 and 18, which are responsible for 70% of cases. The current study’s main aim is to evaluate the impact of using herbal medicine extract for the management of HPV-related cervical and gynaecological pathogenesis.

Methods

A systematic literature was accomplished and 2007 patients with HPV-related diseases were recruited to the current studies; 1 089 of them were treated with herbal extracted products, and 918 were control groups. The inclusion criteria of the current study recruited only randomised clinical trials with a comparison-based design.

Results

Using herbal extracts for the treatment of HPV-related pathogenesis showed a significant improvement in short- and long-term using several plant-based preparations. Improved parameters were the rate of HPV clearance (P < 0.001), rate of cervical intraepithelial neoplasia (P < 0.001), and adverse events (P > 0.05). In contrast to the significant difference between the intervention group and control regarding efficacy-related parameters, there were no significant differences regarding adverse events occurrence rate. The heterogeneity of different model levels was assessed by I² and ranged from 0% to 86.6%.

Conclusions

Using herbal medicine for the management of HPV-related cervical pathogenesis showed a beneficial impact regarding the clearance rate of high-risk HPV and a higher rate of cervical intraepithelial neoplasia regression. In addition, herbal medicines showed high safety rates compared to control.