Simon Helleputte , Jan Stautemas , Marieke De Craemer , Lotte Bogaert , Tine De Backer , Patrick Calders , Bruno Lapauw
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Anthropometrics were collected, and body composition (total and % of fat mass (FM<sub>tot</sub>, FM<sub>%</sub>), total and % of lean mass (LM<sub>tot</sub>, LM<sub>%</sub>), and estimated visceral adipose tissue (VAT)) volume was assessed with dual energy X-ray-absorptiometry (DXA). Estimates of insulin sensitivity were determined (estimated glucose disposal rate (eGDR) and total daily insulin dose). Arterial stiffness was assessed with carotid-femoral pulse wave velocity (cf-PWV (m/s); <em>SphygmoCor®</em>).</p></div><div><h3>Results</h3><p>Lower 10-years HbA1<sub>c</sub> associated moderately with all PA measures. Favourable moderate associations were also found between PA measures and BMI, waist, VAT but not FM and LM. PA measures were favourably associated with a lower total daily insulin dose and higher eGDR. All PA parameters associated moderately with cf-PWV however not independent from traditional risk factors. VO<sub>2max</sub> was inversely associated with cf-PWV independent of age, T1D duration and 24-hour mean blood pressure.</p></div><div><h3>Conclusions</h3><p>Higher levels of PA, lower sedentary behaviour and greater exercise capacity are favourably associated with long-term glycaemic control, body composition, insulin dosage, estimated insulin sensitivity and arterial stiffness in adults with T1D. Therefore, regular PA and limiting sedentary time should be encouraged to improve metabolic and cardiovascular health in this population. Future longitudinal studies should explore mutual interactions and synergistic effects of PA on these outcomes.</p></div>","PeriodicalId":11249,"journal":{"name":"Diabetes research and clinical practice","volume":"217 ","pages":"Article 111860"},"PeriodicalIF":6.1000,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Physical activity and sedentary behaviour in relation to body composition, estimated insulin sensitivity and arterial stiffness in adults with type 1 diabetes\",\"authors\":\"Simon Helleputte , Jan Stautemas , Marieke De Craemer , Lotte Bogaert , Tine De Backer , Patrick Calders , Bruno Lapauw\",\"doi\":\"10.1016/j.diabres.2024.111860\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Aims</h3><p>To examine the association of daily PA levels and sedentary behaviour with body composition, estimated insulin sensitivity, and arterial stiffness in adults with type 1 diabetes (T1D).</p></div><div><h3>Methods</h3><p>Cross-sectional study in adults with T1D (n = 54). PA levels (daily steps, and time in moderate-to-vigorous intensity PA (MVPA)) and sedentary behaviour were measured using accelerometry for 7 days (<em>McRoberts® DynaPort MoveMonitor</em>). Cardiopulmonary exercise test for VO<sub>2max</sub>. Anthropometrics were collected, and body composition (total and % of fat mass (FM<sub>tot</sub>, FM<sub>%</sub>), total and % of lean mass (LM<sub>tot</sub>, LM<sub>%</sub>), and estimated visceral adipose tissue (VAT)) volume was assessed with dual energy X-ray-absorptiometry (DXA). Estimates of insulin sensitivity were determined (estimated glucose disposal rate (eGDR) and total daily insulin dose). Arterial stiffness was assessed with carotid-femoral pulse wave velocity (cf-PWV (m/s); <em>SphygmoCor®</em>).</p></div><div><h3>Results</h3><p>Lower 10-years HbA1<sub>c</sub> associated moderately with all PA measures. Favourable moderate associations were also found between PA measures and BMI, waist, VAT but not FM and LM. PA measures were favourably associated with a lower total daily insulin dose and higher eGDR. All PA parameters associated moderately with cf-PWV however not independent from traditional risk factors. VO<sub>2max</sub> was inversely associated with cf-PWV independent of age, T1D duration and 24-hour mean blood pressure.</p></div><div><h3>Conclusions</h3><p>Higher levels of PA, lower sedentary behaviour and greater exercise capacity are favourably associated with long-term glycaemic control, body composition, insulin dosage, estimated insulin sensitivity and arterial stiffness in adults with T1D. Therefore, regular PA and limiting sedentary time should be encouraged to improve metabolic and cardiovascular health in this population. 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引用次数: 0
摘要
目的 研究 1 型糖尿病（T1D）成人患者的日常活动量水平和久坐行为与身体成分、估计胰岛素敏感性和动脉僵化的关系。方法 对 T1D 成人患者（n = 54）进行横断面研究。使用加速度计（McRoberts® DynaPort MoveMonitor）测量了7天的PA水平（每日步数和中高强度PA（MVPA）时间）和久坐行为。心肺运动测试（VO2max）。收集了人体测量数据，并使用双能 X 射线吸附测量仪（DXA）评估了身体成分（脂肪总量和脂肪百分比（FMtot，FM%）、瘦肉总量和瘦肉百分比（LMtot，LM%）以及内脏脂肪组织（VAT）的估计值）。胰岛素敏感性估计值（估计葡萄糖排出率（eGDR）和每日胰岛素总剂量）也已确定。用颈动脉-股动脉脉搏波速度（cf-PWV (m/s); SphygmoCor®）评估动脉僵化程度。PA 指标与体重指数（BMI）、腰围、腹部脂肪含量（VAT）之间也存在有利的中度相关性，但与 FM 和 LM 无关。PA 指标与较低的每日胰岛素总剂量和较高的 eGDR 呈有利相关。所有 PA 参数均与 cf-PWV 呈中度相关，但与传统风险因素无关。结论较高水平的业余爱好、较少的久坐行为和较强的运动能力与 T1D 成人的长期血糖控制、身体成分、胰岛素用量、胰岛素敏感性估计值和动脉僵硬度密切相关。因此，应鼓励定期进行体育锻炼并限制久坐时间，以改善这一人群的代谢和心血管健康。未来的纵向研究应探讨体育锻炼对这些结果的相互影响和协同作用。
Physical activity and sedentary behaviour in relation to body composition, estimated insulin sensitivity and arterial stiffness in adults with type 1 diabetes
Aims
To examine the association of daily PA levels and sedentary behaviour with body composition, estimated insulin sensitivity, and arterial stiffness in adults with type 1 diabetes (T1D).
Methods
Cross-sectional study in adults with T1D (n = 54). PA levels (daily steps, and time in moderate-to-vigorous intensity PA (MVPA)) and sedentary behaviour were measured using accelerometry for 7 days (McRoberts® DynaPort MoveMonitor). Cardiopulmonary exercise test for VO2max. Anthropometrics were collected, and body composition (total and % of fat mass (FMtot, FM%), total and % of lean mass (LMtot, LM%), and estimated visceral adipose tissue (VAT)) volume was assessed with dual energy X-ray-absorptiometry (DXA). Estimates of insulin sensitivity were determined (estimated glucose disposal rate (eGDR) and total daily insulin dose). Arterial stiffness was assessed with carotid-femoral pulse wave velocity (cf-PWV (m/s); SphygmoCor®).
Results
Lower 10-years HbA1c associated moderately with all PA measures. Favourable moderate associations were also found between PA measures and BMI, waist, VAT but not FM and LM. PA measures were favourably associated with a lower total daily insulin dose and higher eGDR. All PA parameters associated moderately with cf-PWV however not independent from traditional risk factors. VO2max was inversely associated with cf-PWV independent of age, T1D duration and 24-hour mean blood pressure.
Conclusions
Higher levels of PA, lower sedentary behaviour and greater exercise capacity are favourably associated with long-term glycaemic control, body composition, insulin dosage, estimated insulin sensitivity and arterial stiffness in adults with T1D. Therefore, regular PA and limiting sedentary time should be encouraged to improve metabolic and cardiovascular health in this population. Future longitudinal studies should explore mutual interactions and synergistic effects of PA on these outcomes.
期刊介绍：
Diabetes Research and Clinical Practice is an international journal for health-care providers and clinically oriented researchers that publishes high-quality original research articles and expert reviews in diabetes and related areas. The role of the journal is to provide a venue for dissemination of knowledge and discussion of topics related to diabetes clinical research and patient care. Topics of focus include translational science, genetics, immunology, nutrition, psychosocial research, epidemiology, prevention, socio-economic research, complications, new treatments, technologies and therapy.
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