微RNA在糖尿病足溃疡中的作用:机制和可能的干预措施

IF 6.1 3区 医学 Q1 ENDOCRINOLOGY & METABOLISM Diabetes research and clinical practice Pub Date : 2024-09-14 DOI:10.1016/j.diabres.2024.111858
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引用次数: 0

摘要

糖尿病足溃疡(DFU)是糖尿病患者常见的严重并发症,其发病率和治疗难度给患者的健康和生活质量带来了沉重负担。糖尿病足组织通常表现为慢性伤口、溃疡或坏死,难以愈合,容易感染,严重者甚至可能导致截肢。最近的研究表明,微小核糖核酸(miRNA)在脚趾溃疡的发展和愈合过程中起着关键作用。miRNA 是一类非编码 RNA 短分子,可调节基因表达,从而影响细胞功能和生理过程。miRNAs 还可通过调节炎症、血管生成、细胞迁移和增殖、组织修复和基质重塑等关键步骤,参与 DFU 的愈合和恢复。因此,通过调节 miRNAs 的表达来改变糖尿病足的病理过程,可以改善患者的康复和治疗效果。本综述通过总结 miRNAs 在糖尿病足的发生、发展和愈合中的作用及其机制,为糖尿病足的治疗提供了新的见解和视角。
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Role of microRNAs in diabetic foot ulcers: Mechanisms and possible interventions

Diabetic foot ulcer (DFU) is a common and serious complication among diabetic patients, and its incidence and difficulty in treatment have placed large burdens on patient health and quality of life. Diabetic foot tissue typically exhibits chronic wounds, ulcers, or necrosis that are difficult to heal, are prone to infection, and, in severe cases, may even lead to amputation. Recent studies have shown that microRNAs (miRNAs) play key roles in the development and healing of DFUs. miRNAs are a class of short noncoding RNA molecules that regulate gene expression to affect cellular functions and physiological processes. miRNAs may be involved in the development of DFUs by regulating cell growth, proliferation, differentiation and apoptosis. miRNAs can also participate in the healing and recovery of DFUs by regulating key steps, such as inflammation, angiogenesis, cell migration and proliferation, tissue repair and matrix remodeling. Therefore, altering the pathological processes of diabetic foot by modulating the expression of miRNAs could improve the recovery and treatment outcomes of patients. This review provides new insights and perspectives for the treatment of DFUs by summarizing the roles of miRNAs in the development and healing of DFUs and the mechanisms.

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来源期刊
Diabetes research and clinical practice
Diabetes research and clinical practice 医学-内分泌学与代谢
CiteScore
10.30
自引率
3.90%
发文量
862
审稿时长
32 days
期刊介绍: Diabetes Research and Clinical Practice is an international journal for health-care providers and clinically oriented researchers that publishes high-quality original research articles and expert reviews in diabetes and related areas. The role of the journal is to provide a venue for dissemination of knowledge and discussion of topics related to diabetes clinical research and patient care. Topics of focus include translational science, genetics, immunology, nutrition, psychosocial research, epidemiology, prevention, socio-economic research, complications, new treatments, technologies and therapy.
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