用于癌症免疫疗法中光动力 IDO 蛋白溶解的光触发 PROTAC 纳米组件（Adv. Mater.）

IF 27.4 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY Advanced Materials Pub Date : 2024-09-19 DOI:10.1002/adma.202470304

Jiwoong Choi, Byeongmin Park, Jung Yeon Park, Dongwon Shin, Sangmin Lee, Hong Yeol Yoon, Kwangmeyung Kim, Sun Hwa Kim, Yongju Kim, Yoosoo Yang, Man Kyu Shim

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摘要

癌症免疫疗法

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Light-Triggered PROTAC Nanoassemblies for Photodynamic IDO Proteolysis in Cancer Immunotherapy (Adv. Mater. 38/2024)

Cancer Immunotherapy

Man Kyu Shim, Yongju Kim, Yoosoo Yang, and colleagues develope a light-triggered proteolysis-targeting chimera (PROTAC) nanoassembly. This nanoassembly accumulates significantly in tumor tissues, triggering a burst release of active PROTACs. Upon light irradiation, tumor cells undergo immunogenic cell death to promote T cell activation, while the recyclable action of the PROTACs simultaneously blocks regulatory T cell-mediated immunosuppression. More details can be found in article number 2405475.

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来源期刊

Advanced Materials 工程技术-材料科学：综合

CiteScore

43.00

自引率

4.10%

发文量

2182

审稿时长

2 months

期刊介绍： Advanced Materials, one of the world's most prestigious journals and the foundation of the Advanced portfolio, is the home of choice for best-in-class materials science for more than 30 years. Following this fast-growing and interdisciplinary field, we are considering and publishing the most important discoveries on any and all materials from materials scientists, chemists, physicists, engineers as well as health and life scientists and bringing you the latest results and trends in modern materials-related research every week.