应用于护肤策略的重组融合蛋白的分子养殖表达

IF 2.3 3区 生物学 Q2 MULTIDISCIPLINARY SCIENCES PeerJ Pub Date : 2024-09-18 DOI:10.7717/peerj.17957
Guangdong Yu, Wengang Zhao, Yunpeng Wang, Nuo Xu
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引用次数: 0

摘要

本综述讨论了当前护肤品领域分子农业技术的研究进展,重点是分子农业表达策略。此外,还重点介绍了透皮给药策略及其优势。表达与美容相关的融合蛋白已成为提高蛋白功效的重要途径。因此,我们还讨论了在三叶草中表达融合蛋白的可行性和策略,特别是表皮生长因子(EGF)与细胞穿透肽(CPP)的融合,通过植物表达系统可以大大提高生产效率,因为与原核生物、动物和哺乳动物表达系统相比,植物表达系统具有更高的生物安全性、灵活性和扩展性。虽然 EGF 与 CCP 的融合可以增强其透皮能力,但融合蛋白对皮肤修复、黄褐斑、美白和抗衰老的作用还没有得到充分探讨。除此之外,蛋白质与透皮肽的融合为组织修复和再生疗法以及化妆品和美容产品的开发提供了多种可能性。众所周知,某些植物提取物含有对皮肤健康有益的蛋白质,在植物系统中表达这些蛋白质将更好地保持其完整性和生物活性,从而促进更有效的护肤产品的开发。
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Molecular farming expression of recombinant fusion proteins applied to skincare strategies
This review discusses the current research progress in molecular farming technology in the field of skincare, with an emphasis on molecular farming expression strategies. The strategies of transdermal drug delivery and their advantages are also highlighted. The expression of cosmetically relevant fused proteins has become an important way to enhance the efficacy of the proteins. Therefore, we also discuss the feasibility and strategies for expressing fusion proteins in A. thaliana, specifically the fusion of Epidermal growth factor (EGF) to a cell-penetrating peptide (CPP), in which the production can be greatly enhanced via plant expression systems since these systems offer higher biosecurity, flexibility, and expansibility than prokaryotic, animal and mammalian expression systems. While the fusion of EGF to CCP can enhance its transdermal ability, the effects of the fusion protein on skin repair, melasma, whitening, and anti-aging are poorly explored. Beyond this, fusing proteins with transdermal peptides presents multiple possibilities for the development of tissue repair and regeneration therapeutics, as well as cosmetics and beauty products. As certain plant extracts are known to contain proteins beneficial for skin health, the expression of these proteins in plant systems will better maintain their integrity and biological activities, thereby facilitating the development of more effective skincare products.
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来源期刊
PeerJ
PeerJ MULTIDISCIPLINARY SCIENCES-
CiteScore
4.70
自引率
3.70%
发文量
1665
审稿时长
10 weeks
期刊介绍: PeerJ is an open access peer-reviewed scientific journal covering research in the biological and medical sciences. At PeerJ, authors take out a lifetime publication plan (for as little as $99) which allows them to publish articles in the journal for free, forever. PeerJ has 5 Nobel Prize Winners on the Board; they have won several industry and media awards; and they are widely recognized as being one of the most interesting recent developments in academic publishing.
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