含 N,O-羧甲基壳聚糖/醛透明质酸/羟基磷灰石水凝胶的聚己内酯杂化支架用于骨再生

IF 3.2 4区 医学 Q2 ENGINEERING, BIOMEDICAL Journal of biomedical materials research. Part B, Applied biomaterials Pub Date : 2024-09-18 DOI:10.1002/jbm.b.35486
Binh Thanh Vu, Thai Hoang Tran, Khanh Loan Ly, Khanh Phan-Ngoc Trinh, My Ngoc-Hoang Nguyen, Hoan Ngoc Doan, Thanh-Tu Duong, Ha Thi-Ngoc Hua, Hung Thanh Le, Thanh Dinh Le, Nhi Ngoc-Thao Dang, Hiep Thi Nguyen
{"title":"含 N,O-羧甲基壳聚糖/醛透明质酸/羟基磷灰石水凝胶的聚己内酯杂化支架用于骨再生","authors":"Binh Thanh Vu,&nbsp;Thai Hoang Tran,&nbsp;Khanh Loan Ly,&nbsp;Khanh Phan-Ngoc Trinh,&nbsp;My Ngoc-Hoang Nguyen,&nbsp;Hoan Ngoc Doan,&nbsp;Thanh-Tu Duong,&nbsp;Ha Thi-Ngoc Hua,&nbsp;Hung Thanh Le,&nbsp;Thanh Dinh Le,&nbsp;Nhi Ngoc-Thao Dang,&nbsp;Hiep Thi Nguyen","doi":"10.1002/jbm.b.35486","DOIUrl":null,"url":null,"abstract":"<div>\n \n <p>Hydrogels have emerged as potential materials for bone grafting, thanks to their biocompatibility, biodegradation, and flexibility in filling irregular bone defects. In this study, we fabricated a novel NAH hydrogel system, composed of N,O-carboxymethyl chitosan (NOCC), aldehyde hyaluronic acid (AHA), and hydroxyapatite (HAp). To improve the mechanical strength of the fabricated hydrogel, a porous polycaprolactone (PCL) matrix was synthesized and used as a three-dimensional (3D) support template for NAH hydrogel loading, forming a novel PCL/NAH hybrid scaffold. A mixture of monosodium glutamate (M) and sucrose (S) at varied weight ratios (5M:5S, 7M:3S, and 9M:1S) was used for the fabrication of 3D PCL matrices. The morphology, interconnectivity, and water resistance of the porous PCL scaffolds were investigated for optimal hydrogel loading efficiency. The results demonstrated that PCL scaffolds with porogen ratios of 7M:3S and 9M:1S possessed better interconnectivity than 5M:5S ratio. The compressive strength of the PCL/NAH hybrid scaffolds with 9M:1S (561.6 ± 6.1 kPa) and 7M:3S (623.8 ± 6.8 kPa) ratios are similar to cancellous bone and all hybrid scaffolds were biocompatible. Rabbit models with tibial defects were implanted with the PCL/NAH scaffolds to assess the wound healing capability. The results suggest that the PCL/NAH hybrid scaffolds, specifically those with porogen ratio of 7M:3S, exhibit promising bone healing effects.</p>\n </div>","PeriodicalId":15269,"journal":{"name":"Journal of biomedical materials research. Part B, Applied biomaterials","volume":null,"pages":null},"PeriodicalIF":3.2000,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Polycaprolactone Hybrid Scaffold Loaded With N,O-Carboxymethyl Chitosan/Aldehyde Hyaluronic Acid/Hydroxyapatite Hydrogel for Bone Regeneration\",\"authors\":\"Binh Thanh Vu,&nbsp;Thai Hoang Tran,&nbsp;Khanh Loan Ly,&nbsp;Khanh Phan-Ngoc Trinh,&nbsp;My Ngoc-Hoang Nguyen,&nbsp;Hoan Ngoc Doan,&nbsp;Thanh-Tu Duong,&nbsp;Ha Thi-Ngoc Hua,&nbsp;Hung Thanh Le,&nbsp;Thanh Dinh Le,&nbsp;Nhi Ngoc-Thao Dang,&nbsp;Hiep Thi Nguyen\",\"doi\":\"10.1002/jbm.b.35486\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n <p>Hydrogels have emerged as potential materials for bone grafting, thanks to their biocompatibility, biodegradation, and flexibility in filling irregular bone defects. In this study, we fabricated a novel NAH hydrogel system, composed of N,O-carboxymethyl chitosan (NOCC), aldehyde hyaluronic acid (AHA), and hydroxyapatite (HAp). To improve the mechanical strength of the fabricated hydrogel, a porous polycaprolactone (PCL) matrix was synthesized and used as a three-dimensional (3D) support template for NAH hydrogel loading, forming a novel PCL/NAH hybrid scaffold. A mixture of monosodium glutamate (M) and sucrose (S) at varied weight ratios (5M:5S, 7M:3S, and 9M:1S) was used for the fabrication of 3D PCL matrices. The morphology, interconnectivity, and water resistance of the porous PCL scaffolds were investigated for optimal hydrogel loading efficiency. The results demonstrated that PCL scaffolds with porogen ratios of 7M:3S and 9M:1S possessed better interconnectivity than 5M:5S ratio. The compressive strength of the PCL/NAH hybrid scaffolds with 9M:1S (561.6 ± 6.1 kPa) and 7M:3S (623.8 ± 6.8 kPa) ratios are similar to cancellous bone and all hybrid scaffolds were biocompatible. Rabbit models with tibial defects were implanted with the PCL/NAH scaffolds to assess the wound healing capability. The results suggest that the PCL/NAH hybrid scaffolds, specifically those with porogen ratio of 7M:3S, exhibit promising bone healing effects.</p>\\n </div>\",\"PeriodicalId\":15269,\"journal\":{\"name\":\"Journal of biomedical materials research. Part B, Applied biomaterials\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":3.2000,\"publicationDate\":\"2024-09-18\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of biomedical materials research. Part B, Applied biomaterials\",\"FirstCategoryId\":\"5\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1002/jbm.b.35486\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"ENGINEERING, BIOMEDICAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of biomedical materials research. Part B, Applied biomaterials","FirstCategoryId":"5","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/jbm.b.35486","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"ENGINEERING, BIOMEDICAL","Score":null,"Total":0}
引用次数: 0

摘要

水凝胶具有生物相容性、生物降解性和填充不规则骨缺损的灵活性,因此已成为骨移植的潜在材料。在这项研究中,我们制备了一种新型 NAH 水凝胶系统,由 N,O-羧甲基壳聚糖(NOCC)、醛透明质酸(AHA)和羟基磷灰石(HAp)组成。为了提高制成的水凝胶的机械强度,合成了多孔聚己内酯(PCL)基质,并将其用作负载 NAH 水凝胶的三维(3D)支撑模板,形成了新型 PCL/NAH 混合支架。谷氨酸钠(M)和蔗糖(S)以不同的重量比(5M:5S、7M:3S 和 9M:1S)混合制成三维 PCL 基质。研究了多孔 PCL 支架的形态、互联性和耐水性,以获得最佳的水凝胶负载效率。结果表明,与 5M:5S 的比例相比,7M:3S 和 9M:1S 的多孔 PCL 支架具有更好的互联性。9M:1S(561.6 ± 6.1 kPa)和7M:3S(623.8 ± 6.8 kPa)比例的PCL/NAH混合支架的抗压强度与松质骨相似,且所有混合支架均具有生物相容性。将 PCL/NAH 支架植入胫骨缺损的兔子模型,以评估伤口愈合能力。结果表明,PCL/NAH 混合支架,特别是那些孔原比为 7M:3S 的支架,具有良好的骨愈合效果。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
Polycaprolactone Hybrid Scaffold Loaded With N,O-Carboxymethyl Chitosan/Aldehyde Hyaluronic Acid/Hydroxyapatite Hydrogel for Bone Regeneration

Hydrogels have emerged as potential materials for bone grafting, thanks to their biocompatibility, biodegradation, and flexibility in filling irregular bone defects. In this study, we fabricated a novel NAH hydrogel system, composed of N,O-carboxymethyl chitosan (NOCC), aldehyde hyaluronic acid (AHA), and hydroxyapatite (HAp). To improve the mechanical strength of the fabricated hydrogel, a porous polycaprolactone (PCL) matrix was synthesized and used as a three-dimensional (3D) support template for NAH hydrogel loading, forming a novel PCL/NAH hybrid scaffold. A mixture of monosodium glutamate (M) and sucrose (S) at varied weight ratios (5M:5S, 7M:3S, and 9M:1S) was used for the fabrication of 3D PCL matrices. The morphology, interconnectivity, and water resistance of the porous PCL scaffolds were investigated for optimal hydrogel loading efficiency. The results demonstrated that PCL scaffolds with porogen ratios of 7M:3S and 9M:1S possessed better interconnectivity than 5M:5S ratio. The compressive strength of the PCL/NAH hybrid scaffolds with 9M:1S (561.6 ± 6.1 kPa) and 7M:3S (623.8 ± 6.8 kPa) ratios are similar to cancellous bone and all hybrid scaffolds were biocompatible. Rabbit models with tibial defects were implanted with the PCL/NAH scaffolds to assess the wound healing capability. The results suggest that the PCL/NAH hybrid scaffolds, specifically those with porogen ratio of 7M:3S, exhibit promising bone healing effects.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
CiteScore
7.50
自引率
2.90%
发文量
199
审稿时长
12 months
期刊介绍: Journal of Biomedical Materials Research – Part B: Applied Biomaterials is a highly interdisciplinary peer-reviewed journal serving the needs of biomaterials professionals who design, develop, produce and apply biomaterials and medical devices. It has the common focus of biomaterials applied to the human body and covers all disciplines where medical devices are used. Papers are published on biomaterials related to medical device development and manufacture, degradation in the body, nano- and biomimetic- biomaterials interactions, mechanics of biomaterials, implant retrieval and analysis, tissue-biomaterial surface interactions, wound healing, infection, drug delivery, standards and regulation of devices, animal and pre-clinical studies of biomaterials and medical devices, and tissue-biopolymer-material combination products. Manuscripts are published in one of six formats: • original research reports • short research and development reports • scientific reviews • current concepts articles • special reports • editorials Journal of Biomedical Materials Research – Part B: Applied Biomaterials is an official journal of the Society for Biomaterials, Japanese Society for Biomaterials, the Australasian Society for Biomaterials, and the Korean Society for Biomaterials. Manuscripts from all countries are invited but must be in English. Authors are not required to be members of the affiliated Societies, but members of these societies are encouraged to submit their work to the journal for consideration.
期刊最新文献
Accelerated In Vitro Oxidative Degradation Testing of Ultra-High Molecular Weight Polyethylene (UHMWPE) Issue Information Biocompatible and Safe Decellularized Spinach With Antibacterial and Wound Healing Activity In Vitro and In Vivo Biocompatibility of Bacterial Cellulose Molecular Biomarkers for In Vitro Thrombogenicity Assessment of Medical Device Materials
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1