Samuel Hailemichael Henok,Menen Ayalew Shibeshi,Awot Yibrah,Zewdu Terefework,Getahun Tabor Emebet,John H Kempen
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引用次数: 0
摘要
目的我们比较了埃塞俄比亚急性前葡萄膜炎(AAU)患者和无此疾病的对照组中 HLA-B27 等位基因的分布情况。方法从病历中收集患者的临床特征。使用实时聚合酶链式反应(RT-PCR)对 64 名急性前葡萄膜炎患者进行了 HLA-B27 基因分型,并将结果与 192 名没有前葡萄膜炎症状的健康、无血缘关系的志愿者对照组(屈光不正患者和志愿者)的结果进行了比较。结果64例AAU患者中有6例(9.4%)发现了组织相容性抗原HLA-B27,而对照组中只有1.0%(Odds Ratio = 9.8, 95% CI (1.93, 50.01))。对病例进行分组分析后发现,HLA-B27 阳性的患者眼压较高(Odds Ratio = 5.93,95% CI (1.29, 27.2))。病例和对照组中的HLA-B27等位基因分布低于白种人和亚洲人,但与南非相似。
Frequency of HLA-B27 Haplotype Among Patients with Acute Anterior Uveitis and Controls in Ethiopia.
PURPOSE
We compared the distribution of the HLA-B27 allele among Ethiopian patients with acute anterior uveitis (AAU) and controls without that disease.
METHODS
The clinical features of patients were collected from their medical records. HLA-B27 genotyping was performed for 64 patients, with AAU using the real-time polymerase chain reaction (RT-PCR), and the results were compared to those from a panel of 192 healthy, unrelated volunteer control participants (refraction patients and volunteers) free of signs of anterior uveitis. Other outcomes were assessed comparing HLA-B27 positive vs. negative patients.
RESULTS
The histocompatibility antigen HLA-B27 was identified in 6 out of 64 (9.4%) AAU patients, compared with 1.0% in controls (Odds Ratio = 9.8, 95% CI (1.93, 50.01)). Sub-group analysis of the cases revealed that patients with HLA-B27 positivity had a higher incidence of ocular hypertension (Odds Ratio = 5.93, 95% CI (1.29, 27.2)).
CONCLUSION
The antigen HLA-B27 was represented ~10-fold more frequently in the patient group than in the control group. HLA-B27 allele distribution in both cases and controls is lower than in reports from Caucasian and Asian populations, but similar to South Africa.
期刊介绍:
Ocular Immunology & Inflammation ranks 18 out of 59 in the Ophthalmology Category.Ocular Immunology and Inflammation is a peer-reviewed, scientific publication that welcomes the submission of original, previously unpublished manuscripts directed to ophthalmologists and vision scientists. Published bimonthly, the journal provides an international medium for basic and clinical research reports on the ocular inflammatory response and its control by the immune system. The journal publishes original research papers, case reports, reviews, letters to the editor, meeting abstracts, and invited editorials.