银屑病患者的疾病负担对生物疗法转换的影响:来自 CorEvitas 银屑病登记处的真实证据

IF 3.5 3区 医学 Q1 DERMATOLOGY Dermatology and Therapy Pub Date : 2024-09-16 DOI:10.1007/s13555-024-01257-2
Andrew Blauvelt, Robert R. McLean, Silky W. Beaty, Adam P. Sima, Robert Low, Jeffrey L. Stark, Laura McClung, Jerry Bagel
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引用次数: 0

摘要

导言由于银屑病症状、疾病进展和个体对治疗的反应各不相同,患者可能会开始、停止或更换生物制剂疗法。本研究比较了 CorEvitas 银屑病登记处(2017 年 7 月至 2021 年 12 月)中在开始治疗后 4-12 个月内更换生物制剂和未更换生物制剂的患者的疾病负担。记录了与疾病相关的患者报告结果(PROs),包括皮肤疼痛、瘙痒、活动障碍以及对健康相关生活质量(HRQoL)的影响。疾病严重程度通过体表面积(BSA)和银屑病面积与严重程度指数(PASI)进行测量。研究采用未调整和调整回归模型来比较两组患者的研究结果。转换疗法的最常见原因是未能维持初始反应(51.7%;n = 78)。83.0%的转换者(n = 132)和26.1%的非转换者(n = 516)患有中重度疾病(BSA ≥ 3)。49.7%(n = 79)的转换者与 8.6%(n = 171)的非转换者相比,PASI 为 5。有生物治疗经验的患者在皮肤疼痛、瘙痒以及对 HRQoL 的影响方面,转换者与非转换者之间的差异更大。以患者为中心的因素可能是生物制剂转换的重要驱动因素。我们的研究结果表明,对于有过生物制剂治疗经验的患者来说,转换疗法与疾病负担之间的关系可能会更密切。
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Impact of Disease Burden of Patients with Psoriasis on Biologic Therapy Switching: Real-World Evidence from the CorEvitas Psoriasis Registry

Introduction

Due to variable psoriasis symptoms, disease progression, and individual responses to therapy, patients may start, stop, or switch biologic therapies. Real-world data on the associated disease burden of patients with psoriasis who do and do not switch biologics are incomplete.

Methods

This study compared disease burden among patients from the CorEvitas Psoriasis Registry (July 2017–December 2021) who switched biologics and those who did not within 4–12 months following initiation. Disease-related patient-reported outcomes (PROs) were recorded, including skin pain, itching, activity impairment, and effects on health-related quality of life (HRQoL). Disease severity was measured by body surface area (BSA) and Psoriasis Area and Severity Index (PASI). Unadjusted and adjusted regression models were used to compare study outcome measures between the two groups.

Results

This study included 2145 patients, with 159 classified as switchers and 1986 as non-switchers. The most common reason for switching therapy was failure to maintain initial response (51.7%; n = 78). Moderate-to-severe disease (BSA ≥ 3) was found among 83.0% (n = 132) of switchers versus 26.1% (n = 516) of non-switchers. PASI > 5 was reported among 49.7% (n = 79) of switchers versus 8.6% (n = 171) of non-switchers. Differences in skin pain, itching, and effects on HRQoL between switchers and non-switchers were larger in magnitude for bio-experienced patients.

Conclusions

Patients who switched biologic therapy experienced a greater disease burden of psoriasis across PROs than non-switchers. Patient-centered factors may be important drivers of biologic switching. Our findings suggest the association between switching and disease burden may be stronger among patients with prior biologic therapy experience.

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来源期刊
Dermatology and Therapy
Dermatology and Therapy Medicine-Dermatology
CiteScore
6.00
自引率
8.80%
发文量
187
审稿时长
6 weeks
期刊介绍: Dermatology and Therapy is an international, open access, peer-reviewed, rapid publication journal (peer review in 2 weeks, published 3–4 weeks from acceptance). The journal is dedicated to the publication of high-quality clinical (all phases), observational, real-world, and health outcomes research around the discovery, development, and use of dermatological therapies. Studies relating to diagnosis, pharmacoeconomics, public health and epidemiology, quality of life, and patient care, management, and education are also encouraged. Areas of focus include, but are not limited to all clinical aspects of dermatology, such as skin pharmacology; skin development and aging; prevention, diagnosis, and management of skin disorders and melanomas; research into dermal structures and pathology; and all areas of aesthetic dermatology, including skin maintenance, dermatological surgery, and lasers. The journal is of interest to a broad audience of pharmaceutical and healthcare professionals and publishes original research, reviews, case reports/case series, trial protocols, and short communications. Dermatology and Therapy will consider all scientifically sound research be it positive, confirmatory or negative data. Submissions are welcomed whether they relate to an International and/or a country-specific audience, something that is crucially important when researchers are trying to target more specific patient populations. This inclusive approach allows the journal to assist in the dissemination of quality research, which may be considered of insufficient interest by other journals. The journal appeals to a global audience and receives submissions from all over the world.
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