使用肼酮与醛类、烯类和胺类轻松合成多种 1,3,5-三取代的 1,2,4- 三唑

IF 2.8 4区化学 Q1 CHEMISTRY, ORGANIC Asian Journal of Organic Chemistry Pub Date : 2024-09-18 DOI:10.1002/ajoc.202400424

Yi Liu, Kunyi Zhang, Jialiang Zhang, Shuaikun Liu, Yu Song, Xinqiang Tan, Lizhen Fang

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引用次数: 0

摘要

通过肼与醛、烯或胺的[3+2]环化反应合成 1,3,5-取代的 1,2,4-三唑衍生物的高效简便方法已经建立。这种策略的特点是使用廉价易得的氧化剂和起始原料，底物范围更广，收率适中甚至很高。

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Facile Synthesis of Diverse 1,3,5-Trisubstituted 1,2,4-Triazole using Hydrazones with Aldehydes, Alkenes, Amines

An efficient, and easy method for the synthesis of 1,3,5- substituted 1,2,4-triazole derivatives by [3+2] annulation reactions of hydrazones with aldehydes, alkenes, or amines has been established. This strategy is characterized by the use of inexpensive and readily available oxidants and starting materials, a broader substrate scope, and moderate to good yields.

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来源期刊

Asian Journal of Organic Chemistry CHEMISTRY, ORGANIC-

CiteScore

4.70

自引率

3.70%

发文量

372

期刊介绍： Organic chemistry is the fundamental science that stands at the heart of chemistry, biology, and materials science. Research in these areas is vigorous and truly international, with three major regions making almost equal contributions: America, Europe and Asia. Asia now has its own top international organic chemistry journal—the Asian Journal of Organic Chemistry (AsianJOC) The AsianJOC is designed to be a top-ranked international research journal and publishes primary research as well as critical secondary information from authors across the world. The journal covers organic chemistry in its entirety. Authors and readers come from academia, the chemical industry, and government laboratories.