全面回顾具有治疗潜力的化学实体吡唑的合成策略和已上市药物的 MOA

IF 2.2 4区 化学 Q3 CHEMISTRY, MULTIDISCIPLINARY Journal of the Iranian Chemical Society Pub Date : 2024-09-17 DOI:10.1007/s13738-024-03095-7
Sucheta Singh, Kuldeep Singh, Sumit Tahlan
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引用次数: 0

摘要

多年来,含氮杂环因其结构的多样性和生物学意义一直是理想的合成目标。五元杂环或吡唑是设计有效生物活性化合物的灵活起点,广泛应用于药物化学、药物发现、农业化学、配位化学和有机金属化学。吡唑衍生物在杂环化学中发挥着重要作用,并因其易于获得、化学反应活性多样化以及广泛的生物特性(包括抗菌、抗炎、抗癌、镇痛、抗惊厥、驱虫、抗氧化和除草特性)而被广泛研究。吡唑核的合成方法多种多样,包括多组分法、双极环加成法、肼与羰基体系的环缩合法、杂环体系和多组分法。本综述试图了解迄今已报道的含吡唑上市药物的化学性质和药用重要性,这无疑将有助于科学界在分离和合成基于吡唑的新型生物活性化合物方面取得进一步进展。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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A comprehensive review on synthetic strategy and MOA of marketed drugs having therapeutically potential chemical entity pyrazole

Nitrogen-containing heterocycles have been desirable targets for synthesis for many years because of their structural diversity and biological significance. Five-membered heterocyclic rings, or pyrazole, are a flexible starting point for the design of effective bioactive compounds and are widely used in medicinal chemistry, drug discovery, agrochemistry, coordination chemistry, and organometallic chemistry. Pyrazole derivatives have played an important role in heterocyclic chemistry and have been extensively studied owing to their ease of access, diversified chemical reactivity, and broad biological properties, including antibacterial, anti-inflammatory, anticancer, analgesic, anticonvulsant, anthelmintic, antioxidant, and herbicidal properties. Pyrazole nuclei are synthesized via a variety of methods, including the multicomponent approach, dipolar cycloaddition, cyclocondensation of hydrazine with a carbonyl system, heterocyclic system, and multicomponent approach. The current review is an attempt to understand the chemistry and medicinal importance of the pyrazole-containing marketed drugs reported to date, which will undoubtedly assist the scientific community in making further advances in the isolation and synthesis of pyrazole-based novel bioactive compounds.

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来源期刊
CiteScore
4.40
自引率
8.30%
发文量
230
审稿时长
5.6 months
期刊介绍: JICS is an international journal covering general fields of chemistry. JICS welcomes high quality original papers in English dealing with experimental, theoretical and applied research related to all branches of chemistry. These include the fields of analytical, inorganic, organic and physical chemistry as well as the chemical biology area. Review articles discussing specific areas of chemistry of current chemical or biological importance are also published. JICS ensures visibility of your research results to a worldwide audience in science. You are kindly invited to submit your manuscript to the Editor-in-Chief or Regional Editor. All contributions in the form of original papers or short communications will be peer reviewed and published free of charge after acceptance.
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