充血性心力衰竭患者抑郁症状轨迹和风险因素纵向研究

Julia Gallucci, Justin Ng, Maria T. Secara, Brett D.M Jones, Colin Hawco, M. Omair Husain, Nusrat Husain, Imran B. Chaudhry, Aristotle N. Voineskos, Muhammad Ishrat Husain
{"title":"充血性心力衰竭患者抑郁症状轨迹和风险因素纵向研究","authors":"Julia Gallucci, Justin Ng, Maria T. Secara, Brett D.M Jones, Colin Hawco, M. Omair Husain, Nusrat Husain, Imran B. Chaudhry, Aristotle N. Voineskos, Muhammad Ishrat Husain","doi":"10.1101/2024.09.16.24313783","DOIUrl":null,"url":null,"abstract":"Background: Depression is prevalent among patients with congestive heart failure (CHF) and is associated with increased mortality and healthcare utilization. However, most research has focused on high-income countries, leaving a gap in knowledge regarding the relationship between depression and CHF in low-to-middle-income countries (LMICs). This study aimed to delineate depressive symptom trajectories and identify potential risk factors for poor outcomes among CHF patients. Methods: Longitudinal data from 783 patients with CHF from public hospitals in Karachi, Pakistan was analyzed. Depressive symptom severity was assessed using the Beck Depression Inventory (BDI). Baseline and 6-month follow-up BDI scores were clustered through Gaussian Mixture Modeling to identify distinct depressive symptom subgroups and extract trajectory labels. Further, a random forest algorithm was utilized to determine baseline demographic, clinical, and behavioral predictors for each trajectory. Results: Four depressive symptom trajectories were identified: 'good prognosis,' 'remitting course,' 'clinical worsening,' and 'persistent course.' Risk factors associated with persistent depressive symptoms included lower quality of life and the New York Heart Association (NYHA) class 3 classification of CHF. Protective factors linked to a good prognosis included less disability and a non-NYHA class 3 classification of CHF. Conclusions: By identifying key characteristics of patients at heightened risk of depression, clinicians can be aware of risk factors and better identify patients who may need greater monitoring and appropriate follow-up care. Keywords: congestive heart failure, depressive symptom trajectories, low-to-middle-income countries, risk factors, protective factors, longitudinal study.","PeriodicalId":501297,"journal":{"name":"medRxiv - Cardiovascular Medicine","volume":"20 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"A longitudinal study of depressive symptom trajectories and risk factors in congestive heart failure\",\"authors\":\"Julia Gallucci, Justin Ng, Maria T. Secara, Brett D.M Jones, Colin Hawco, M. Omair Husain, Nusrat Husain, Imran B. Chaudhry, Aristotle N. Voineskos, Muhammad Ishrat Husain\",\"doi\":\"10.1101/2024.09.16.24313783\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Background: Depression is prevalent among patients with congestive heart failure (CHF) and is associated with increased mortality and healthcare utilization. However, most research has focused on high-income countries, leaving a gap in knowledge regarding the relationship between depression and CHF in low-to-middle-income countries (LMICs). This study aimed to delineate depressive symptom trajectories and identify potential risk factors for poor outcomes among CHF patients. Methods: Longitudinal data from 783 patients with CHF from public hospitals in Karachi, Pakistan was analyzed. Depressive symptom severity was assessed using the Beck Depression Inventory (BDI). Baseline and 6-month follow-up BDI scores were clustered through Gaussian Mixture Modeling to identify distinct depressive symptom subgroups and extract trajectory labels. Further, a random forest algorithm was utilized to determine baseline demographic, clinical, and behavioral predictors for each trajectory. Results: Four depressive symptom trajectories were identified: 'good prognosis,' 'remitting course,' 'clinical worsening,' and 'persistent course.' Risk factors associated with persistent depressive symptoms included lower quality of life and the New York Heart Association (NYHA) class 3 classification of CHF. Protective factors linked to a good prognosis included less disability and a non-NYHA class 3 classification of CHF. Conclusions: By identifying key characteristics of patients at heightened risk of depression, clinicians can be aware of risk factors and better identify patients who may need greater monitoring and appropriate follow-up care. Keywords: congestive heart failure, depressive symptom trajectories, low-to-middle-income countries, risk factors, protective factors, longitudinal study.\",\"PeriodicalId\":501297,\"journal\":{\"name\":\"medRxiv - Cardiovascular Medicine\",\"volume\":\"20 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-09-17\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"medRxiv - Cardiovascular Medicine\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1101/2024.09.16.24313783\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"medRxiv - Cardiovascular Medicine","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1101/2024.09.16.24313783","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

摘要

背景:抑郁症在充血性心力衰竭(CHF)患者中很普遍,并与死亡率和医疗保健利用率的增加有关。然而,大多数研究都集中在高收入国家,对于中低收入国家抑郁症与充血性心力衰竭之间的关系还缺乏了解。本研究旨在描述慢性阻塞性肺疾病患者的抑郁症状轨迹,并确定导致不良预后的潜在风险因素。研究方法分析了巴基斯坦卡拉奇公立医院 783 名 CHF 患者的纵向数据。抑郁症状严重程度采用贝克抑郁量表(BDI)进行评估。通过高斯混合模型对基线和 6 个月随访的 BDI 评分进行聚类,以识别不同的抑郁症状亚组并提取轨迹标签。此外,还利用随机森林算法来确定每个轨迹的基线人口、临床和行为预测因素。结果确定了四种抑郁症状轨迹:预后良好"、"缓解过程"、"临床恶化 "和 "持续过程"。与持续性抑郁症状相关的风险因素包括较低的生活质量和纽约心脏病协会(NYHA)对 CHF 的 3 级分类。与良好预后相关的保护因素包括较少的残疾和非纽约心脏病协会 CHF 3 级分类。结论:通过识别抑郁症高危患者的主要特征,临床医生可以了解风险因素,更好地识别可能需要加强监测和适当随访的患者。关键词:充血性心力衰竭、抑郁症状轨迹、中低收入国家、风险因素、保护因素、纵向研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
A longitudinal study of depressive symptom trajectories and risk factors in congestive heart failure
Background: Depression is prevalent among patients with congestive heart failure (CHF) and is associated with increased mortality and healthcare utilization. However, most research has focused on high-income countries, leaving a gap in knowledge regarding the relationship between depression and CHF in low-to-middle-income countries (LMICs). This study aimed to delineate depressive symptom trajectories and identify potential risk factors for poor outcomes among CHF patients. Methods: Longitudinal data from 783 patients with CHF from public hospitals in Karachi, Pakistan was analyzed. Depressive symptom severity was assessed using the Beck Depression Inventory (BDI). Baseline and 6-month follow-up BDI scores were clustered through Gaussian Mixture Modeling to identify distinct depressive symptom subgroups and extract trajectory labels. Further, a random forest algorithm was utilized to determine baseline demographic, clinical, and behavioral predictors for each trajectory. Results: Four depressive symptom trajectories were identified: 'good prognosis,' 'remitting course,' 'clinical worsening,' and 'persistent course.' Risk factors associated with persistent depressive symptoms included lower quality of life and the New York Heart Association (NYHA) class 3 classification of CHF. Protective factors linked to a good prognosis included less disability and a non-NYHA class 3 classification of CHF. Conclusions: By identifying key characteristics of patients at heightened risk of depression, clinicians can be aware of risk factors and better identify patients who may need greater monitoring and appropriate follow-up care. Keywords: congestive heart failure, depressive symptom trajectories, low-to-middle-income countries, risk factors, protective factors, longitudinal study.
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
自引率
0.00%
发文量
0
期刊最新文献
Where Adults with Heart Failure Die: Insights from the CDC-WONDER Database A longitudinal study of depressive symptom trajectories and risk factors in congestive heart failure Right Ventricular Work and Pulmonary Capillary Wedge Pressure in Heart Failure with Preserved Ejection Fraction Association Between Life's Essential 8 and Atherogenic Index of Plasma in Adults: Insights from NHANES 2007-2018 Efficacy and Safety of Nicorandil for Prevention of Contrast-Induced Nephropathy in Patients Undergoing Coronary Procedures: A Systematic Review and Meta-Analysis
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1