挑战人工瓣膜设计中的长期逆向偏差：为先进的机械瓣膜开辟道路。

medRxiv - Cardiovascular Medicine Pub Date : 2024-09-13 DOI:10.1101/2024.09.12.24313331

LAWRENCE N. SCOTTEN, Dylan Goode, Rolland Siegel, David J. Blundon, James W. Dutton, Hadi Mohammadi

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摘要

结果：瓣膜的性能优于临床对照组结论：候选 MHV 原型的关闭性能优于目前的 SAVR 人工瓣膜，包括生物假体控制瓣膜。

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Challenging the Chronic Perverse Bias in Prosthetic Valve Design: A Pathway Opens for Advanced Mechanical Valves.

Objective: -In vitro evaluation of several prototype mechanical valves compared to present-day SAVR prosthetic valves. Method: -simulated normal cardiac pressures and flows -gravity pressure head column tester flows -recorded valve hydrodynamics and kinematics Results: -valves superior in performance to clinical controls Conclusions: -Prototype MHV candidates outperform the closing performance of present-day SAVR prosthetic valves, including bioprosthetic control.

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medRxiv - Cardiovascular Medicine

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