Larry Milshteyn,Anton Villamejor,Akil Merchant,Joseph Lownik
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引用次数: 0
摘要
外周 T 细胞淋巴瘤(PTCL)是侵袭性非霍奇金淋巴瘤中的一种异质性淋巴瘤,预后不良,治疗方案有限。由于缺乏能准确模拟该疾病病理生理学的可靠临床前模型,阻碍了 PTCL 治疗策略的开发和完善。我们迫切需要更多与生理学相关的 PTCL 模型。在这里,我们描述了一种自发性CD8+外周T细胞淋巴瘤细胞系(LM-23),该细胞系来源于一只12周大的雌性Balb/cJ小鼠。将该细胞系静脉注射和皮下注射给合成Balb/cJ小鼠均可导致肿瘤快速生长。CHOP和抗PD1治疗在调节肿瘤生长方面对小鼠均无益处。这些结果及其表型特征、快速生长和在合成小鼠中的转移行为凸显了它在研究这种难以捉摸的疾病和发现新型疗法方面的价值。
A novel murine syngeneic CD8 peripheral T-cell lymphoma model with preclinical applications.
Peripheral T-cell Lymphoma (PTCL) represents a heterogenous group of aggressive non-Hodgkin Lymphomas with poor prognostic outcomes and limited treatment options. The development and refinement of therapeutic strategies for PTCL are impeded by a paucity of reliable preclinical models that accurately mimic the disease's pathophysiology. There is a dire need for more physiologically relevant models for PTCL. Here we describe a spontaneousCD8+ peripheral T-cell lymphoma cell line (LM-23) derived from a 12-week-old female Balb/cJ mouse. Both intravenous and subcutaneous administration of this cell line to syngeneic Balb/cJ mice resulted in rapid establishment of tumor growth. CHOP and anti-PD1 treatment both displayed no benefit to mice in regulating tumor growth. Such results along with its phenotypic characteristics, rapid growth, and metastatic behavior in syngeneic mice highlight its value in studying the elusive disease and discovery of novel therapeutics.
期刊介绍:
Leukemia & Lymphoma in its fourth decade continues to provide an international forum for publication of high quality clinical, translational, and basic science research, and original observations relating to all aspects of hematological malignancies. The scope ranges from clinical and clinico-pathological investigations to fundamental research in disease biology, mechanisms of action of novel agents, development of combination chemotherapy, pharmacology and pharmacogenomics as well as ethics and epidemiology. Submissions of unique clinical observations or confirmatory studies are considered and published as Letters to the Editor