{"title":"以同时产生和消耗信号的 T 细胞动力学为模型的趋化系统中的稳定问题","authors":"Youshan Tao, Michael Winkler","doi":"10.1017/s0956792524000299","DOIUrl":null,"url":null,"abstract":"In a smoothly bounded domain <jats:inline-formula> <jats:alternatives> <jats:inline-graphic xmlns:xlink=\"http://www.w3.org/1999/xlink\" mime-subtype=\"png\" xlink:href=\"S0956792524000299_inline1.png\"/> <jats:tex-math> $\\Omega \\subset \\mathbb{R}^n$ </jats:tex-math> </jats:alternatives> </jats:inline-formula>, <jats:inline-formula> <jats:alternatives> <jats:inline-graphic xmlns:xlink=\"http://www.w3.org/1999/xlink\" mime-subtype=\"png\" xlink:href=\"S0956792524000299_inline2.png\"/> <jats:tex-math> $n\\ge 1$ </jats:tex-math> </jats:alternatives> </jats:inline-formula>, this manuscript considers the homogeneous Neumann boundary problem for the chemotaxis system<jats:disp-formula> <jats:alternatives> <jats:graphic xmlns:xlink=\"http://www.w3.org/1999/xlink\" mime-subtype=\"png\" mimetype=\"image\" position=\"float\" xlink:href=\"S0956792524000299_eqnU1.png\"/> <jats:tex-math> \\begin{eqnarray*} \\left \\{ \\begin{array}{l} u_t = \\Delta u - \\nabla \\cdot (u\\nabla v), \\\\[5pt] v_t = \\Delta v + u - \\alpha uv, \\end{array} \\right . \\end{eqnarray*} </jats:tex-math> </jats:alternatives> </jats:disp-formula>with parameter <jats:inline-formula> <jats:alternatives> <jats:inline-graphic xmlns:xlink=\"http://www.w3.org/1999/xlink\" mime-subtype=\"png\" xlink:href=\"S0956792524000299_inline3.png\"/> <jats:tex-math> $\\alpha \\gt 0$ </jats:tex-math> </jats:alternatives> </jats:inline-formula> and with coincident production and uptake of attractants, as recently emphasized by Dallaston et al. as relevant for the understanding of T-cell dynamics. It is shown that there exists <jats:inline-formula> <jats:alternatives> <jats:inline-graphic xmlns:xlink=\"http://www.w3.org/1999/xlink\" mime-subtype=\"png\" xlink:href=\"S0956792524000299_inline4.png\"/> <jats:tex-math> $\\delta _\\star =\\delta _\\star (n)\\gt 0$ </jats:tex-math> </jats:alternatives> </jats:inline-formula> such that for any given <jats:inline-formula> <jats:alternatives> <jats:inline-graphic xmlns:xlink=\"http://www.w3.org/1999/xlink\" mime-subtype=\"png\" xlink:href=\"S0956792524000299_inline5.png\"/> <jats:tex-math> $\\alpha \\ge \\frac{1}{\\delta _\\star }$ </jats:tex-math> </jats:alternatives> </jats:inline-formula> and for any suitably regular initial data satisfying <jats:inline-formula> <jats:alternatives> <jats:inline-graphic xmlns:xlink=\"http://www.w3.org/1999/xlink\" mime-subtype=\"png\" xlink:href=\"S0956792524000299_inline6.png\"/> <jats:tex-math> $v(\\cdot, 0)\\le \\delta _\\star$ </jats:tex-math> </jats:alternatives> </jats:inline-formula>, this problem admits a unique classical solution that stabilizes to the constant equilibrium <jats:inline-formula> <jats:alternatives> <jats:inline-graphic xmlns:xlink=\"http://www.w3.org/1999/xlink\" mime-subtype=\"png\" xlink:href=\"S0956792524000299_inline7.png\"/> <jats:tex-math> $(\\frac{1}{|\\Omega |}\\int _\\Omega u(\\cdot, 0), \\, \\frac{1}{\\alpha })$ </jats:tex-math> </jats:alternatives> </jats:inline-formula> in the large time limit.","PeriodicalId":51046,"journal":{"name":"European Journal of Applied Mathematics","volume":"2 1","pages":""},"PeriodicalIF":2.3000,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Stabilization in a chemotaxis system modelling T-cell dynamics with simultaneous production and consumption of signals\",\"authors\":\"Youshan Tao, Michael Winkler\",\"doi\":\"10.1017/s0956792524000299\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"In a smoothly bounded domain <jats:inline-formula> <jats:alternatives> <jats:inline-graphic xmlns:xlink=\\\"http://www.w3.org/1999/xlink\\\" mime-subtype=\\\"png\\\" xlink:href=\\\"S0956792524000299_inline1.png\\\"/> <jats:tex-math> $\\\\Omega \\\\subset \\\\mathbb{R}^n$ </jats:tex-math> </jats:alternatives> </jats:inline-formula>, <jats:inline-formula> <jats:alternatives> <jats:inline-graphic xmlns:xlink=\\\"http://www.w3.org/1999/xlink\\\" mime-subtype=\\\"png\\\" xlink:href=\\\"S0956792524000299_inline2.png\\\"/> <jats:tex-math> $n\\\\ge 1$ </jats:tex-math> </jats:alternatives> </jats:inline-formula>, this manuscript considers the homogeneous Neumann boundary problem for the chemotaxis system<jats:disp-formula> <jats:alternatives> <jats:graphic xmlns:xlink=\\\"http://www.w3.org/1999/xlink\\\" mime-subtype=\\\"png\\\" mimetype=\\\"image\\\" position=\\\"float\\\" xlink:href=\\\"S0956792524000299_eqnU1.png\\\"/> <jats:tex-math> \\\\begin{eqnarray*} \\\\left \\\\{ \\\\begin{array}{l} u_t = \\\\Delta u - \\\\nabla \\\\cdot (u\\\\nabla v), \\\\\\\\[5pt] v_t = \\\\Delta v + u - \\\\alpha uv, \\\\end{array} \\\\right . \\\\end{eqnarray*} </jats:tex-math> </jats:alternatives> </jats:disp-formula>with parameter <jats:inline-formula> <jats:alternatives> <jats:inline-graphic xmlns:xlink=\\\"http://www.w3.org/1999/xlink\\\" mime-subtype=\\\"png\\\" xlink:href=\\\"S0956792524000299_inline3.png\\\"/> <jats:tex-math> $\\\\alpha \\\\gt 0$ </jats:tex-math> </jats:alternatives> </jats:inline-formula> and with coincident production and uptake of attractants, as recently emphasized by Dallaston et al. as relevant for the understanding of T-cell dynamics. It is shown that there exists <jats:inline-formula> <jats:alternatives> <jats:inline-graphic xmlns:xlink=\\\"http://www.w3.org/1999/xlink\\\" mime-subtype=\\\"png\\\" xlink:href=\\\"S0956792524000299_inline4.png\\\"/> <jats:tex-math> $\\\\delta _\\\\star =\\\\delta _\\\\star (n)\\\\gt 0$ </jats:tex-math> </jats:alternatives> </jats:inline-formula> such that for any given <jats:inline-formula> <jats:alternatives> <jats:inline-graphic xmlns:xlink=\\\"http://www.w3.org/1999/xlink\\\" mime-subtype=\\\"png\\\" xlink:href=\\\"S0956792524000299_inline5.png\\\"/> <jats:tex-math> $\\\\alpha \\\\ge \\\\frac{1}{\\\\delta _\\\\star }$ </jats:tex-math> </jats:alternatives> </jats:inline-formula> and for any suitably regular initial data satisfying <jats:inline-formula> <jats:alternatives> <jats:inline-graphic xmlns:xlink=\\\"http://www.w3.org/1999/xlink\\\" mime-subtype=\\\"png\\\" xlink:href=\\\"S0956792524000299_inline6.png\\\"/> <jats:tex-math> $v(\\\\cdot, 0)\\\\le \\\\delta _\\\\star$ </jats:tex-math> </jats:alternatives> </jats:inline-formula>, this problem admits a unique classical solution that stabilizes to the constant equilibrium <jats:inline-formula> <jats:alternatives> <jats:inline-graphic xmlns:xlink=\\\"http://www.w3.org/1999/xlink\\\" mime-subtype=\\\"png\\\" xlink:href=\\\"S0956792524000299_inline7.png\\\"/> <jats:tex-math> $(\\\\frac{1}{|\\\\Omega |}\\\\int _\\\\Omega u(\\\\cdot, 0), \\\\, \\\\frac{1}{\\\\alpha })$ </jats:tex-math> </jats:alternatives> </jats:inline-formula> in the large time limit.\",\"PeriodicalId\":51046,\"journal\":{\"name\":\"European Journal of Applied Mathematics\",\"volume\":\"2 1\",\"pages\":\"\"},\"PeriodicalIF\":2.3000,\"publicationDate\":\"2024-09-18\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"European Journal of Applied Mathematics\",\"FirstCategoryId\":\"100\",\"ListUrlMain\":\"https://doi.org/10.1017/s0956792524000299\",\"RegionNum\":4,\"RegionCategory\":\"数学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"MATHEMATICS, APPLIED\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"European Journal of Applied Mathematics","FirstCategoryId":"100","ListUrlMain":"https://doi.org/10.1017/s0956792524000299","RegionNum":4,"RegionCategory":"数学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"MATHEMATICS, APPLIED","Score":null,"Total":0}
Stabilization in a chemotaxis system modelling T-cell dynamics with simultaneous production and consumption of signals
In a smoothly bounded domain $\Omega \subset \mathbb{R}^n$ , $n\ge 1$ , this manuscript considers the homogeneous Neumann boundary problem for the chemotaxis system \begin{eqnarray*} \left \{ \begin{array}{l} u_t = \Delta u - \nabla \cdot (u\nabla v), \\[5pt] v_t = \Delta v + u - \alpha uv, \end{array} \right . \end{eqnarray*} with parameter $\alpha \gt 0$ and with coincident production and uptake of attractants, as recently emphasized by Dallaston et al. as relevant for the understanding of T-cell dynamics. It is shown that there exists $\delta _\star =\delta _\star (n)\gt 0$ such that for any given $\alpha \ge \frac{1}{\delta _\star }$ and for any suitably regular initial data satisfying $v(\cdot, 0)\le \delta _\star$ , this problem admits a unique classical solution that stabilizes to the constant equilibrium $(\frac{1}{|\Omega |}\int _\Omega u(\cdot, 0), \, \frac{1}{\alpha })$ in the large time limit.
期刊介绍:
Since 2008 EJAM surveys have been expanded to cover Applied and Industrial Mathematics. Coverage of the journal has been strengthened in probabilistic applications, while still focusing on those areas of applied mathematics inspired by real-world applications, and at the same time fostering the development of theoretical methods with a broad range of applicability. Survey papers contain reviews of emerging areas of mathematics, either in core areas or with relevance to users in industry and other disciplines. Research papers may be in any area of applied mathematics, with special emphasis on new mathematical ideas, relevant to modelling and analysis in modern science and technology, and the development of interesting mathematical methods of wide applicability.