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Stabilization in a chemotaxis system modelling T-cell dynamics with simultaneous production and consumption of signals 以同时产生和消耗信号的 T 细胞动力学为模型的趋化系统中的稳定问题
IF 1.9 4区 数学 Q1 MATHEMATICS, APPLIED Pub Date : 2024-09-18 DOI: 10.1017/s0956792524000299
Youshan Tao, Michael Winkler
In a smoothly bounded domain $Omega subset mathbb{R}^n$ , $nge 1$ , this manuscript considers the homogeneous Neumann boundary problem for the chemotaxis system begin{eqnarray*} left { begin{array}{l} u_t = Delta u - nabla cdot (unabla v), [5pt] v_t = Delta v + u - alpha uv, end{array} right . end{eqnarray*} with parameter $alpha gt 0$ and with coincident production and uptake of attractants, as recently emphasized by Dallaston et al. as relevant for the understanding of T-cell dynamics. It is shown that there exists $delta _star =delta _star (n)gt 0$ such that for any given $alpha ge frac{1}{delta _star }$ and for any suitably regular initial data satisfying $v(cdot, 0)le delta _star$ , this problem admits a unique classical solution that stabilizes to the constant equilibrium $(frac{1}{|Omega |}int _Omega u(cdot, 0), , frac{1}{alpha })$ in the large time limit.
在一个光滑有界域 $Omega subset mathbb{R}^n$ , $nge 1$ 中,本手稿考虑了趋化系统的同构 Neumann 边界问题 begin{eqnarray*}u_t = Delta u - nabla cdot (unabla v), [5pt] v_t = Delta v + u - alpha uv, end{array} .右边.end{eqnarray*} 参数为 $alpha gt 0$,并且吸引子的产生和吸收是重合的,正如达拉斯顿等人最近强调的那样,这与理解 T 细胞动力学相关。研究表明,存在$delta _star =delta _star (n)gt 0$,这样对于任何给定的$alpha ge frac{1}{delta _star }$和任何满足$v(cdot、0)le delta _star$, 这个问题有一个唯一的经典解,它在大时间极限内稳定在恒定均衡 $(frac{1}{|Omega |}int _Omega u(cdot, 0), , frac{1}{alpha })$ 中。
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引用次数: 0
Optimal transport through a toll station 通过收费站的最佳运输方式
IF 1.9 4区 数学 Q1 MATHEMATICS, APPLIED Pub Date : 2024-09-18 DOI: 10.1017/s0956792524000317
Arthur Stephanovitch, Anqi Dong, Tryphon T. Georgiou
We address the problem of optimal transport with a quadratic cost functional and a constraint on the flux through a constriction along the path. The constriction, conceptually represented by a toll station, limits the flow rate across. We provide a precise formulation which, in addition, is amenable to generalization in higher dimensions. We work out in detail the case of transport in one dimension by proving existence and uniqueness of solution. Under suitable regularity assumptions, we give an explicit construction of the transport plan. Generalization of flux constraints to higher dimensions and possible extensions of the theory are discussed.
我们要解决的问题是,在二次成本函数的作用下,通过路径上的一个限制条件,对流量进行优化运输。在概念上,该限制条件由收费站表示,限制了通过该限制条件的流量。我们提供了一个精确的公式,此外,它还可以在更高的维度上进行推广。我们通过证明解的存在性和唯一性,详细研究了一维运输的情况。在适当的正则性假设下,我们给出了运输计划的明确构造。我们还讨论了将通量约束推广到更高维度以及理论的可能扩展。
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引用次数: 0
Exact recovery of community detection in k-community Gaussian mixture models k 个群落高斯混合物模型中群落检测的精确恢复
IF 1.9 4区 数学 Q1 MATHEMATICS, APPLIED Pub Date : 2024-09-18 DOI: 10.1017/s0956792524000263
Zhongyang Li
We study the community detection problem on a Gaussian mixture model, in which vertices are divided into $kgeq 2$ distinct communities. The major difference in our model is that the intensities for Gaussian perturbations are different for different entries in the observation matrix, and we do not assume that every community has the same number of vertices. We explicitly find the necessary and sufficient conditions for the exact recovery of the maximum likelihood estimation, which can give a sharp phase transition for the exact recovery even though the Gaussian perturbations are not identically distributed; see Section 7. Applications include the community detection on hypergraphs.
我们研究的是高斯混合模型上的社群检测问题,在该模型中,顶点被分为 $kgeq 2$ 个不同的社群。我们模型的主要区别在于,高斯扰动的强度对观测矩阵中的不同条目是不同的,而且我们不假设每个群落都有相同数量的顶点。我们明确找到了最大似然估计精确恢复的必要条件和充分条件,即使高斯扰动不是同分布的,也能为精确恢复提供急剧的相变;见第 7 节。应用包括超图上的群落检测。
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引用次数: 0
Travelling waves with continuous profile for hyperbolic Keller-Segel equation 双曲凯勒-西格尔方程具有连续剖面的游波
IF 1.9 4区 数学 Q1 MATHEMATICS, APPLIED Pub Date : 2024-09-18 DOI: 10.1017/s0956792524000305
Quentin Griette, Pierre Magal, Min Zhao
This work describes a hyperbolic model for cell-cell repulsion with population dynamics. We consider the pressure produced by a population of cells to describe their motion. We assume that cells try to avoid crowded areas and prefer locally empty spaces far away from the carrying capacity. Here, our main goal is to prove the existence of travelling waves with continuous profiles. This article complements our previous results about sharp travelling waves. We conclude the paper with numerical simulations of the PDE problem, illustrating such a result. An application to wound healing also illustrates the importance of travelling waves with a continuous and discontinuous profile.
这项工作描述了一个具有群体动力学的双曲线细胞排斥模型。我们考虑细胞群产生的压力来描述它们的运动。我们假设细胞会尽量避开拥挤的区域,而喜欢远离承载能力的局部空旷空间。在此,我们的主要目标是证明具有连续剖面的行波的存在性。本文补充了我们之前关于尖锐行波的研究成果。最后,我们通过对 PDE 问题的数值模拟来说明这一结果。对伤口愈合的应用也说明了具有连续和不连续剖面的行波的重要性。
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引用次数: 0
Non-linear biphasic mixture model: Existence and uniqueness results 非线性双相混合模型:存在性和唯一性结果
IF 1.9 4区 数学 Q1 MATHEMATICS, APPLIED Pub Date : 2024-09-18 DOI: 10.1017/s0956792524000251
Meraj Alam, Adrian Muntean, Raja Sekhar G P
This paper is concerned with the development and analysis of a mathematical model that is motivated by interstitial hydrodynamics and tissue deformation mechanics (poro-elasto-hydrodynamics) within an in-vitro solid tumour. The classical mixture theory is adopted for mass and momentum balance equations for a two-phase system. A main contribution of this study is we treat the physiological transport parameter (i.e., hydraulic resistivity) as anisotropic and heterogeneous, thus the governing system is strongly coupled and non-linear. We derived a weak formulation and then formulated the equivalent fixed-point problem. This enabled us to use the Galerkin method, and the classical results on monotone operators combined with the well-known Schauder and Banach fixed-point theorems to prove the existence and uniqueness of results.
本文主要研究体外实体瘤内的间隙流体力学和组织变形力学(孔-胃-流体力学)对数学模型的开发和分析。两相系统的质量和动量平衡方程采用了经典混合物理论。本研究的主要贡献在于,我们将生理传输参数(即水电阻率)视为各向异性的异质参数,因此调控系统是强耦合和非线性的。我们导出了一个弱公式,然后提出了等效定点问题。这使我们能够使用 Galerkin 方法、单调算子的经典结果以及著名的 Schauder 和 Banach 定点定理来证明结果的存在性和唯一性。
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引用次数: 0
Local geometric properties of conductive transmission eigenfunctions and applications 导电传输特征函数的局部几何特性及其应用
IF 1.9 4区 数学 Q1 MATHEMATICS, APPLIED Pub Date : 2024-09-18 DOI: 10.1017/s0956792524000287
Huaian Diao, Xiaoxu Fei, Hongyu Liu
The purpose of the paper is twofold. First, we show that partial-data transmission eigenfunctions associated with a conductive boundary condition vanish locally around a polyhedral or conic corner in $mathbb{R}^n$ , $n=2,3$ . Second, we apply the spectral property to the geometrical inverse scattering problem of determining the shape as well as its boundary impedance parameter of a conductive scatterer, independent of its medium content, by a single far-field measurement. We establish several new unique recovery results. The results extend the relevant ones in [26] in two directions: first, we consider a more general geometric setup where both polyhedral and conic corners are investigated, whereas in [26] only polyhedral corners are concerned; second, we significantly relax the regularity assumptions in [26] which is particularly useful for the geometrical inverse problem mentioned above. We develop novel technical strategies to achieve these new results.
本文有两个目的。首先,我们证明与导电边界条件相关的部分数据传输特征函数在 $mathbb{R}^n$ 中的多面体或圆锥角周围局部消失,$n=2,3$。其次,我们将光谱特性应用于几何反向散射问题,即通过一次远场测量确定导电散射体的形状及其边界阻抗参数,而与介质含量无关。我们建立了几个新的独特恢复结果。这些结果在两个方向上扩展了 [26] 中的相关结果:首先,我们考虑了一种更普遍的几何设置,即同时研究多面体角和圆锥角,而在 [26] 中只涉及多面体角;其次,我们大大放宽了 [26] 中的正则性假设,这对上述几何反问题特别有用。我们开发了新颖的技术策略来实现这些新结果。
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引用次数: 0
Maintenance of steady-state mRNA levels by a microRNA-based feed forward loop in the presence of stochastic gene expression noise 在存在随机基因表达噪音的情况下,通过基于微RNA的前馈回路维持稳态mRNA水平
IF 1.9 4区 数学 Q1 Mathematics Pub Date : 2024-05-29 DOI: 10.1017/s095679252400024x
Iryna Zabaikina, Pavol Bokes

All vital functions of living cells rely on the production of various functional molecules through gene expression. The production periods are burst-like and stochastic due to the discrete nature of biochemical reactions. In certain contexts, the concentrations of RNA or protein require regulation to maintain a fine internal balance within the cell. Here we consider a motif of two types of RNA molecules – mRNA and an antagonistic microRNA – which are encoded by a shared coding sequence and form a feed forward loop (FFL). This control mechanism is shown to be perfectly adapting in the deterministic context. We demonstrate that the adaptation (of the mean value) becomes imperfect if production occurs in random bursts. The FFL nevertheless outperforms the benchmark feedback loop in terms of counterbalancing variations in the signal. Methodologically, we adapt a hybrid stochastic model, which has widely been used to model a single regulatory molecule, to the current case of a motif involving two species; the use of the Laplace transform thereby circumvents the problem of moment closure that arises owing to the mRNA–microRNA interaction. We expect that the approach can be applicable to other systems with nonlinear kinetics.

活细胞的所有重要功能都依赖于通过基因表达产生各种功能分子。由于生化反应的离散性,生产过程具有突发性和随机性。在某些情况下,RNA 或蛋白质的浓度需要调节,以维持细胞内部的微妙平衡。在这里,我们考虑了由两种 RNA 分子(mRNA 和一种拮抗 microRNA)组成的图案,它们由一个共享的编码序列编码,并形成一个前馈回路(FFL)。研究表明,这种控制机制在确定性背景下具有完美的适应性。我们证明,如果以随机猝发的方式产生,(平均值的)适应性就会变得不完美。尽管如此,FFL 在平衡信号变化方面仍优于基准反馈回路。在方法上,我们将广泛用于单个调控分子建模的混合随机模型应用于当前涉及两个物种的动机;拉普拉斯变换的使用从而规避了由于 mRNA 与 microRNA 相互作用而产生的时刻闭合问题。我们希望这种方法能适用于其他非线性动力学系统。
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引用次数: 0
Opinion formation on evolving network: the DPA method applied to a nonlocal cross-diffusion PDE-ODE system 演化网络中的意见形成:应用于非局部交叉扩散 PDE-ODE 系统的 DPA 方法
IF 1.9 4区 数学 Q1 Mathematics Pub Date : 2024-05-21 DOI: 10.1017/s0956792524000093
Simone Fagioli, Gianluca Favre
We study a system of nonlocal aggregation cross-diffusion PDEs that describe the evolution of opinion densities on a network. The PDEs are coupled with a system of ODEs that describe the time evolution of the agents on the network. Firstly, we apply the Deterministic Particle Approximation (DPA) method to the aforementioned system in order to prove the existence of solutions under suitable assumptions on the interactions between agents. Later on, we present an explicit model for opinion formation on an evolving network. The opinions evolve based on both the distance between the agents on the network and the ’attitude areas’, which depend on the distance between the agents’ opinions. The position of the agents on the network evolves based on the distance between the agents’ opinions. The goal is to study radicalisation, polarisation and fragmentation of the population while changing its open-mindedness and the radius of interaction.
我们研究了一个非局部聚集交叉扩散 PDEs 系统,该系统描述了网络上舆论密度的演变。该 PDEs 与描述网络上代理的时间演化的 ODEs 系统相耦合。首先,我们将确定性粒子逼近(DPA)方法应用于上述系统,以证明在代理之间相互作用的适当假设条件下,解的存在性。随后,我们提出了一个在不断演化的网络上形成意见的明确模型。意见的演变基于网络上代理之间的距离和 "态度区域",而 "态度区域 "则取决于代理意见之间的距离。代理在网络中的位置根据代理意见之间的距离而变化。我们的目标是研究激进化、两极分化和人口分化,同时改变其思想开放程度和互动半径。
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引用次数: 0
Diffuse-interface approximation and weak–strong uniqueness of anisotropic mean curvature flow 各向异性平均曲率流的扩散-界面近似和弱-强唯一性
IF 1.9 4区 数学 Q1 Mathematics Pub Date : 2024-05-16 DOI: 10.1017/s0956792524000226
Tim Laux, Kerrek Stinson, Clemens Ullrich
The purpose of this paper is to derive anisotropic mean curvature flow as the limit of the anisotropic Allen–Cahn equation. We rely on distributional solution concepts for both the diffuse and sharp interface models and prove convergence using relative entropy methods, which have recently proven to be a powerful tool in interface evolution problems. With the same relative entropy, we prove a weak–strong uniqueness result, which relies on the construction of gradient flow calibrations for our anisotropic energy functionals.
本文旨在将各向异性平均曲率流推导为各向异性 Allen-Cahn 方程的极限。我们依赖于扩散和尖锐界面模型的分布解概念,并使用相对熵方法证明了收敛性,这种方法最近被证明是界面演化问题的有力工具。利用相同的相对熵,我们证明了弱-强唯一性结果,这依赖于为各向异性能量函数构建梯度流校准。
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引用次数: 0
Binary pattern retrieval with Kuramoto-type oscillators via a least orthogonal lift of three patterns 通过三个模式的最小正交提升,用 Kuramoto 型振荡器进行二进制模式检索
IF 1.9 4区 数学 Q1 Mathematics Pub Date : 2024-05-16 DOI: 10.1017/s0956792524000238
Xiaoxue Zhao, Zhuchun Li
Given a set of standard binary patterns and a defective pattern, the pattern retrieval task is to find the closest pattern to the defective one among these standard patterns. The Hebbian network of Kuramoto oscillators with second-order coupling provides a dynamical model for this task, and the mutual orthogonality in memorised patterns enables us to distinguish these memorised patterns from most others in terms of stability. For the sake of error-free retrieval for general problems lacking orthogonality, a unified approach was proposed which transforms the problem into a series of subproblems with orthogonality using the orthogonal lift for two patterns. In this work, we propose the least orthogonal lift for three patterns, which evidently reduces the time of solving subproblems and even the dimensions of subproblems. Furthermore, we provide an estimate for the critical strength for stability/instability of binary patterns, which is convenient in practical use. Simulation results are presented to illustrate the effectiveness of the proposed approach.
给定一组标准二进制模式和一个缺陷模式,模式检索任务就是在这些标准模式中找出与缺陷模式最接近的模式。具有二阶耦合的仓本振荡器海比网络为这项任务提供了一个动力学模型,而记忆模式中的相互正交性使我们能够从稳定性方面将这些记忆模式与大多数其他模式区分开来。为了对缺乏正交性的一般问题进行无差错检索,有人提出了一种统一方法,即利用两个模式的正交提升将问题转化为一系列具有正交性的子问题。在这项工作中,我们提出了针对三种模式的最小正交提升,这明显缩短了解决子问题的时间,甚至减少了子问题的维数。此外,我们还提供了二元模式稳定性/不稳定性临界强度的估计值,这在实际应用中非常方便。仿真结果说明了所提方法的有效性。
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引用次数: 0
期刊
European Journal of Applied Mathematics
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