戈来西替尼首次批准

IF 13 1区医学 Q1 PHARMACOLOGY & PHARMACY Drugs Pub Date : 2024-09-19 DOI:10.1007/s40265-024-02089-2

Susan J. Keam

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引用次数: 0

摘要

高瑞哲®（Golidocitinib）是一种口服、强效、选择性Janus激酶1（JAK1）抑制剂，由滴丸（江苏）制药有限公司开发，用于治疗癌症，包括外周T细胞淋巴瘤（PTCL）。2024 年 6 月，戈来西替尼在中国获得有条件批准，用于治疗接受过至少一线系统治疗的复发或难治性（r/r）PTCL 成年患者。本文总结了戈来替尼研发过程中的里程碑事件，这些事件促成了戈来替尼首次获批用于治疗成人PTCL患者。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Golidocitinib: First Approval

Golidocitinib (高瑞哲^®) is an oral, potent, selective Janus kinase 1 (JAK1) inhibitor being developed by Dizal (Jiangsu) Pharmaceutical Co., Ltd for the treatment of cancer, including peripheral T cell lymphoma (PTCL). In June 2024, golidocitinib received conditional approval in China for the treatment of adult patients with relapsed or refractory (r/r) PTCL who have received at least one line of systemic treatment. This article summarizes the milestones in the development of golidocitinib leading to this first approval for the treatment of adults with PTCL.

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来源期刊

Drugs 医学-毒理学

CiteScore

22.70

自引率

0.90%

发文量

134

审稿时长

3-8 weeks

期刊介绍： Drugs is a journal that aims to enhance pharmacotherapy by publishing review and original research articles on key aspects of clinical pharmacology and therapeutics. The journal includes: Leading/current opinion articles providing an overview of contentious or emerging issues. Definitive reviews of drugs and drug classes, and their place in disease management. Therapy in Practice articles including recommendations for specific clinical situations. High-quality, well designed, original clinical research. Adis Drug Evaluations reviewing the properties and place in therapy of both newer and established drugs. AdisInsight Reports summarising development at first global approval. Moreover, the journal offers additional digital features such as animated abstracts, video abstracts, instructional videos, and podcasts to increase visibility and educational value. Plain language summaries accompany articles to assist readers with some knowledge of the field in understanding important medical advances.

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