镍催化肉桂酸的 O-甲基化反应（使用二甲基亚砜作为甲基替代物

IF 1.7 4区化学 Q3 CHEMISTRY, ORGANIC Synlett Pub Date : 2024-09-16 DOI:10.1055/a-2384-6807

Hrishikesh Talukdar, Prodeep Phukan

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引用次数: 0

摘要

采用 Ni-DMAP 复合物作为催化剂，Ag2O 和二甲胺作为添加剂，设计出了一种以二甲基亚砜为甲基化剂的肉桂酸 O-甲基化新方法。该方案具有广泛的底物兼容性和对各种官能团的良好耐受性。这种方法的主要优点包括使用成本效益高的催化剂、中等到较高的产物产率和较短的反应时间。

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Nickel-Catalyzed O-Methylation of Cinnamic Acid Using DMSO as Methyl Surrogate

A new method for the O-methylation of cinnamic acid employing DMSO as the methylating agent has been devised, employing a Ni-DMAP complex as catalyst along with Ag₂O and dimethylamine as additives. This protocol demonstrates broad substrate compatibility and good tolerance towards various functional groups. The key advantages of this approach include the utilization of cost-effective catalysts, moderate to high yield of the products, and short reaction time.

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来源期刊

Synlett 化学-有机化学

CiteScore

3.40

自引率

5.00%

发文量

369

审稿时长

1 months

期刊介绍： SYNLETT is an international journal reporting research results and current trends in chemical synthesis in short personalized reviews and preliminary communications. It covers all fields of scientific endeavor that involve organic synthesis, including catalysis, organometallic, medicinal, biological, and photochemistry, but also related disciplines and offers the possibility to publish scientific primary data.