聚（甘油己二酸酯）网络材料在组织工程应用领域的最新进展

IF 4.3 3区工程技术 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Frontiers in Bioengineering and Biotechnology Pub Date : 2024-09-18 DOI:10.3389/fbioe.2024.1447340

Anna Kłusak, Małgorzata Anna Gazińska

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引用次数: 0

摘要

聚（己二酸甘油酯）（PGA）是甘油脂肪族聚酯之一。对聚（己二酸甘油酯）生物医学应用研究最多的是将其纳米颗粒用作药物输送载体。PGA 预聚物可以交联成网络材料。直到最近，PGA 网络材料的生物医学应用在很大程度上仍未得到开发。基于 PGA 的网络材料，如聚（甘油癸二酸酯）弹性体，因其机械性能可用于软组织再生。PGA 弹性体的弹性模量在 MPa 范围内，符合人体软组织的机械特性。这篇简短的综述旨在简要总结近年来研究出版物中提到的 PGA 弹性体在组织工程中的可能应用。

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Recent progress of poly(glycerol adipate)-based network materials toward tissue engineering applications

Poly(glycerol adipate) (PGA) is one of the aliphatic polyesters of glycerol. The most studied biomedical application of poly(glycerol adipate) is the use of its nanoparticles as drug delivery carriers. The PGA prepolymer can be crosslinked to network materials. The biomedical application of PGA-based network materials has largely remained unexplored till recently. The PGA-based network materials, such as poly(glycerol sebacate) elastomers, can be used in soft tissue regeneration due to their mechanical properties. The modulus of elasticity of PGA elastomers is within the range of MPa, which corresponds to the mechanical properties of human soft tissues. This short review aims at briefly summarizing the possible applications of PGA-based elastomers in tissue engineering, as indicated in recent years in research publications.

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来源期刊

Frontiers in Bioengineering and Biotechnology Chemical Engineering-Bioengineering

CiteScore

8.30

自引率

5.30%

发文量

2270

审稿时长

12 weeks

期刊介绍： The translation of new discoveries in medicine to clinical routine has never been easy. During the second half of the last century, thanks to the progress in chemistry, biochemistry and pharmacology, we have seen the development and the application of a large number of drugs and devices aimed at the treatment of symptoms, blocking unwanted pathways and, in the case of infectious diseases, fighting the micro-organisms responsible. However, we are facing, today, a dramatic change in the therapeutic approach to pathologies and diseases. Indeed, the challenge of the present and the next decade is to fully restore the physiological status of the diseased organism and to completely regenerate tissue and organs when they are so seriously affected that treatments cannot be limited to the repression of symptoms or to the repair of damage. This is being made possible thanks to the major developments made in basic cell and molecular biology, including stem cell science, growth factor delivery, gene isolation and transfection, the advances in bioengineering and nanotechnology, including development of new biomaterials, biofabrication technologies and use of bioreactors, and the big improvements in diagnostic tools and imaging of cells, tissues and organs. In today`s world, an enhancement of communication between multidisciplinary experts, together with the promotion of joint projects and close collaborations among scientists, engineers, industry people, regulatory agencies and physicians are absolute requirements for the success of any attempt to develop and clinically apply a new biological therapy or an innovative device involving the collective use of biomaterials, cells and/or bioactive molecules. “Frontiers in Bioengineering and Biotechnology” aspires to be a forum for all people involved in the process by bridging the gap too often existing between a discovery in the basic sciences and its clinical application.