在配备高性能梯度插件的临床前磁共振成像扫描仪上修正螺旋轨迹

IF 2.7 4区 医学 Q2 BIOPHYSICS NMR in Biomedicine Pub Date : 2024-09-13 DOI:10.1002/nbm.5249
Hannah Scholten, Tobias Wech, Sascha Köhler, Sean S. Smart, Jordan H. Boyle, Irvin Teh, Herbert Köstler, Jürgen E. Schneider
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引用次数: 0

摘要

本研究旨在研究临床前扫描仪上的高性能梯度螺旋成像的不同轨迹校正方法对模型和体内图像质量的影响。在单独实验中测量轨迹的金标准方法与各向同性延迟校正法、使用梯度系统传递函数(GSTF)的校正法以及两者的结合进行了比较。实验考虑了三种不同的螺旋轨迹,分别为 96、16 和 3 个交错轨迹。在单独的模型测量中确定轨迹时,始终能获得最佳图像质量。然而,特别是对于 96 个交错点的螺旋轨迹,其他校正方法的结果几乎不相上下。校正后的梯度波形和轨迹中的其余瑕疵可归因于实际生成的梯度中出现的不对称起伏,这表明违反了基本的线性假设。总之,在临床前小型动物扫描仪上使用螺旋 k 空间轨迹可以获得足够质量的图像,而无需每次都进行单独的轨迹测量。根据轨迹的不同,简单的各向同性延迟校正或基于 GSTF 的校正可以提供类似质量的图像。
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On the correction of spiral trajectories on a preclinical MRI scanner with a high‐performance gradient insert
This study aimed to examine different trajectory correction methods for spiral imaging on a preclinical scanner with high‐performance gradients with respect to image quality in a phantom and in vivo. The gold standard method of measuring the trajectories in a separate experiment is compared to an isotropic delay‐correction, a correction using the gradient system transfer function (GSTF), and a combination of the two. Three different spiral trajectories, with 96, 16, and three interleaves, are considered. The best image quality is consistently achieved when determining the trajectory in a separate phantom measurement. However, especially for the spiral with 96 interleaves, the other correction methods lead to almost comparable results. Remaining imperfections in the corrected gradient waveforms and trajectories are attributed to asymmetrically occurring undulations in the actual, generated gradients, suggesting that the underlying assumption of linearity is violated. In conclusion, images of sufficient quality can be acquired on preclinical small‐animal scanners using spiral k‐space trajectories without the need to carry out separate trajectory measurements each time. Depending on the trajectory, a simple isotropic delay‐correction or a GSTF‐based correction can provide images of similar quality.
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来源期刊
NMR in Biomedicine
NMR in Biomedicine 医学-光谱学
CiteScore
6.00
自引率
10.30%
发文量
209
审稿时长
3-8 weeks
期刊介绍: NMR in Biomedicine is a journal devoted to the publication of original full-length papers, rapid communications and review articles describing the development of magnetic resonance spectroscopy or imaging methods or their use to investigate physiological, biochemical, biophysical or medical problems. Topics for submitted papers should be in one of the following general categories: (a) development of methods and instrumentation for MR of biological systems; (b) studies of normal or diseased organs, tissues or cells; (c) diagnosis or treatment of disease. Reports may cover work on patients or healthy human subjects, in vivo animal experiments, studies of isolated organs or cultured cells, analysis of tissue extracts, NMR theory, experimental techniques, or instrumentation.
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