Sarcopenia

IF 76.9 1区 医学 Q1 MEDICINE, GENERAL & INTERNAL Nature Reviews Disease Primers Pub Date : 2024-09-19 DOI:10.1038/s41572-024-00550-w
Avan A. Sayer, Rachel Cooper, Hidenori Arai, Peggy M. Cawthon, Marie-Josiane Ntsama Essomba, Roger A. Fielding, Miranda D. Grounds, Miles D. Witham, Alfonso J. Cruz-Jentoft
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引用次数: 0

摘要

肌肉疏松症是骨骼肌质量和功能的加速丧失,通常(但不限于)与年龄增长有关。在包括人类在内的许多物种中都可观察到这种现象,它会导致身体功能和活动能力下降,并增加跌倒、骨折和过早死亡等不良后果的风险。尽管由于对 "肌肉疏松症 "的定义不同,对其患病率的估计也不尽相同,但即使采用保守的方法,一般人群中的患病率也在 5%到 10%之间。有人提出了一个生命过程框架,不仅用于了解肌肉疏松症在晚年的发生情况,还用于了解早年阶段的影响因素,这可能对预防策略产生重要影响。要了解肌肉疏松症的病理生理学,关键是要在了解老化特征方面取得进展。在过去 10 年中,诊断肌肉疏松症的方法出现了很大的趋同,肌肉力量的重要性日益受到重视。阻力运动是目前的主要治疗方法,但并不适合所有人。因此,需要辅助和替代治疗来提高生活质量。国际公认的定义和诊断方法将使这一领域发生阶跃性变化,并有可能在不久的将来通过 "全球肌肉疏松症领导者倡议 "得以实现。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Sarcopenia

Sarcopenia is the accelerated loss of skeletal muscle mass and function commonly, but not exclusively, associated with advancing age. It is observed across many species including humans in whom it can lead to decline in physical function and mobility as well as to increased risk of adverse outcomes including falls, fractures and premature mortality. Although prevalence estimates vary because sarcopenia has been defined in different ways, even using a conservative approach, the prevalence is between 5% and 10% in the general population. A life course framework has been proposed for understanding not only the occurrence of sarcopenia in later life but also influences operating at earlier life stages with potentially important implications for preventive strategies. Harnessing progress in understanding the hallmarks of ageing has been key to understanding sarcopenia pathophysiology. Considerable convergence in approaches to diagnosis of sarcopenia has occurred over the last 10 years, with a growing emphasis on the central importance of muscle strength. Resistance exercise is currently the mainstay of treatment; however, it is not suitable for all. Hence, adjunctive and alternative treatments to improve quality of life are needed. An internationally agreed approach to definition and diagnosis will enable a step change in the field and is likely to be available in the near future through the Global Leadership Initiative in Sarcopenia.

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来源期刊
Nature Reviews Disease Primers
Nature Reviews Disease Primers Medicine-General Medicine
CiteScore
76.70
自引率
0.20%
发文量
75
期刊介绍: Nature Reviews Disease Primers, a part of the Nature Reviews journal portfolio, features sections on epidemiology, mechanisms, diagnosis, management, and patient quality of life. The editorial team commissions top researchers — comprising basic scientists and clinical researchers — to write the Primers, which are designed for use by early career researchers, medical students and principal investigators. Each Primer concludes with an Outlook section, highlighting future research directions. Covered medical specialties include Cardiology, Dermatology, Ear, Nose and Throat, Emergency Medicine, Endocrinology, Gastroenterology, Genetic Conditions, Gynaecology and Obstetrics, Hepatology, Haematology, Infectious Diseases, Maxillofacial and Oral Medicine, Nephrology, Neurology, Nutrition, Oncology, Ophthalmology, Orthopaedics, Psychiatry, Respiratory Medicine, Rheumatology, Sleep Medicine, and Urology.
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