α-突触核蛋白淀粉样纤维直接与 LC3B 结合并抑制 SQSTM1/p62 介导的选择性自噬作用

IF 28.1 1区生物学 Q1 CELL BIOLOGY Cell Research Pub Date : 2024-09-19 DOI:10.1038/s41422-024-01022-2

Qianhui Xu, Huilan Wang, Ruonan Yang, Youqi Tao, Ziying Wang, Shengnan Zhang, Bo Sun, Dan Li, Boxun Lu, Cong Liu

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引用次数: 0

摘要

亲爱的编辑，帕金森病（Parkinson's disease，PD）是一种进行性神经退行性疾病，表现为α-突触核蛋白（α-syn）组成的病理性淀粉样纤维异常聚集成路易体，并导致黑质多巴胺能神经元功能衰退。5,6选择性自噬的关键自噬体蛋白LC3B和α-syn在帕金森病患者大脑路易体中的共定位7表明，α-syn在调节选择性自噬中可能发挥作用8。

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α-Synuclein amyloid fibril directly binds to LC3B and suppresses SQSTM1/p62-mediated selective autophagy

Dear Editor,

Parkinson’s disease (PD) is a progressive neurodegenerative disorder, which manifests through the abnormal accumulation of pathological amyloid fibrils composed of α-synuclein (α-syn) into Lewy bodies and the deterioration of dopaminergic neurons in the substantia nigra.^1,2,3,4 In addition to α-syn fibrillar aggregation, the disruption of selective autophagy is also tightly linked to the pathogenesis of PD.^5,6 The co-localization of LC3B, the key autophagosome protein in selective autophagy,⁷ and α-syn in the Lewy bodies of PD patients’ brains points towards a potential role of α-syn in modulating selective autophagy.⁸ Yet, the interplay between them has not been mechanistically elucidated.

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来源期刊

Cell Research 生物-细胞生物学

CiteScore

53.90

自引率

0.70%

发文量

2420

审稿时长

2.3 months

期刊介绍： Cell Research (CR) is an international journal published by Springer Nature in partnership with the Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences (CAS). It focuses on publishing original research articles and reviews in various areas of life sciences, particularly those related to molecular and cell biology. The journal covers a broad range of topics including cell growth, differentiation, and apoptosis; signal transduction; stem cell biology and development; chromatin, epigenetics, and transcription; RNA biology; structural and molecular biology; cancer biology and metabolism; immunity and molecular pathogenesis; molecular and cellular neuroscience; plant molecular and cell biology; and omics, system biology, and synthetic biology. CR is recognized as China's best international journal in life sciences and is part of Springer Nature's prestigious family of Molecular Cell Biology journals.

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