利用模拟和实验数据验证冬季精英面包小麦的杂交后代方差基因组预测

IF 4.4 1区 农林科学 Q1 AGRONOMY Theoretical and Applied Genetics Pub Date : 2024-09-18 DOI:10.1007/s00122-024-04718-6
Claire Oget-Ebrad, Emmanuel Heumez, Laure Duchalais, Ellen Goudemand-Dugué, François-Xavier Oury, Jean-Michel Elsen, Sophie Bouchet
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引用次数: 0

摘要

关键信息从模拟和实验数据来看,杂交后代方差基因组预测的质量可能很高,但这取决于性状结构,而且需要足够数量的后代。有用性标准(UC)是一种杂交选择标准,需要估计亲本平均值(PM)和后代标准偏差(SD)。本研究通过模拟评估了影响有用性标准预测能力的参数及其两个组成部分。预测能力随遗传率和后代大小的增加而提高,随 QTL 数量的增加而降低,尤其是 SD。在已知标记效应或使用预测模型估计标记效应的情况下,SD 受标记效应估计质量的影响很大。我们提出了一种新的 SD 估算代数公式,该公式考虑了标记效应估算的不确定性。当 QTL 数量多于 300 时,尤其是遗传率较低时,它能改善预测结果。我们还利用打顶日期、株高、谷物蛋白质含量和产量的实验数据,比较了估计的 UC 和观察到的 UC。在所有性状中,PM 和 UC 估计值都有明显的相关性(PM:0.38、0.63、0.51 和 0.91;UC:UC:0.45、0.52、0.54 和 0.74;分别针对产量、谷物蛋白质含量、株高和打顶日期),而 SD 仅针对打顶日期和株高具有相关性(分别为 0.64 和 0.49)。模拟结果表明,在田间进行自交系测定需要大量后代。这项开创性的研究通过实验验证了 UC 的基因组预测,但预测能力取决于性状结构和标记效应估计的精确度。我们建议育种者调整后代大小,以发挥杂交种的自交系潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Validation of cross-progeny variance genomic prediction using simulations and experimental data in winter elite bread wheat

Key message

From simulations and experimental data, the quality of cross progeny variance genomic predictions may be high, but depends on trait architecture and necessitates sufficient number of progenies.

Abstract

Genomic predictions are used to select genitors and crosses in plant breeding. The usefulness criterion (UC) is a cross-selection criterion that necessitates the estimation of parental mean (PM) and progeny standard deviation (SD). This study evaluates the parameters that affect the predictive ability of UC and its two components using simulations. Predictive ability increased with heritability and progeny size and decreased with QTL number, most notably for SD. Comparing scenarios where marker effects were known or estimated using prediction models, SD was strongly impacted by the quality of marker effect estimates. We proposed a new algebraic formula for SD estimation that takes into account the uncertainty of the estimation of marker effects. It improved predictions when the number of QTL was superior to 300, especially when heritability was low. We also compared estimated and observed UC using experimental data for heading date, plant height, grain protein content and yield. PM and UC estimates were significantly correlated for all traits (PM: 0.38, 0.63, 0.51 and 0.91; UC: 0.45, 0.52, 0.54 and 0.74; for yield, grain protein content, plant height and heading date, respectively), while SD was correlated only for heading date and plant height (0.64 and 0.49, respectively). According to simulations, SD estimations in the field would necessitate large progenies. This pioneering study experimentally validates genomic prediction of UC but the predictive ability depends on trait architecture and precision of marker effect estimates. We advise the breeders to adjust progeny size to realize the SD potential of a cross.

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来源期刊
CiteScore
9.60
自引率
7.40%
发文量
241
审稿时长
2.3 months
期刊介绍: Theoretical and Applied Genetics publishes original research and review articles in all key areas of modern plant genetics, plant genomics and plant biotechnology. All work needs to have a clear genetic component and significant impact on plant breeding. Theoretical considerations are only accepted in combination with new experimental data and/or if they indicate a relevant application in plant genetics or breeding. Emphasizing the practical, the journal focuses on research into leading crop plants and articles presenting innovative approaches.
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