急性肺损伤中的 SIRT1：揭示其多效应功能和治疗开发前景

IF 3.5 2区生物学 Q3 CELL BIOLOGY Molecular and Cellular Biochemistry Pub Date : 2024-09-13 DOI:10.1007/s11010-024-05111-z

Yina Chen, Shuangyan Peng, Junjie Liang, Ke Wei

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引用次数: 0

摘要

急性肺损伤（ALI）是由多种肺损伤引起的连续性肺部变化，通常伴有严重的并发症，甚至死亡。在 ALI 中，肺部的巨噬细胞、肺泡上皮细胞和血管内皮细胞受到不同程度的损伤，其功能也受到损害。近年来的研究重点是利用 SIRT1 治疗 ALI。本文从SIRT1的细胞和分子机制、非编码RNA和药物成分对SIRT1的靶向作用等方面综述了SIRT1在ALI中的作用，并指出了SIRT1在临床诊断和预后判断中的价值。根据目前的文献，SIRT1 表现出多种功能，具有巨大的治疗潜力。以 SIRT1 为靶点可为 ALI 的治疗提供新的治疗思路。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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SIRT1 in acute lung injury: unraveling its pleiotropic functions and therapeutic development prospects

Acute lung injury (ALI) is a continuum of lung changes caused by multiple lung injuries, often associated with severe complications and even death. In ALI, macrophages, alveolar epithelial cells and vascular endothelial cells in the lung are damaged to varying degrees and their function is impaired. Research in recent years has focused on the use of SIRT1 for the treatment of ALI. In this paper, we reviewed the role of SIRT1 in ALI in terms of its cellular and molecular mechanism, targeting of SIRT1 by non-coding RNAs and drug components, as well as pointing out the value of SIRT1 for clinical diagnosis and prognosis. Based on the current literature, SIRT1 exhibits diverse functionalities and possesses significant therapeutic potential. Targeting SIRT1 may provide new therapeutic ideas for the treatment of ALI.

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来源期刊

Molecular and Cellular Biochemistry 生物-细胞生物学

CiteScore

8.30

自引率

2.30%

发文量

293

审稿时长

1.7 months

期刊介绍： Molecular and Cellular Biochemistry: An International Journal for Chemical Biology in Health and Disease publishes original research papers and short communications in all areas of the biochemical sciences, emphasizing novel findings relevant to the biochemical basis of cellular function and disease processes, as well as the mechanics of action of hormones and chemical agents. Coverage includes membrane transport, receptor mechanism, immune response, secretory processes, and cytoskeletal function, as well as biochemical structure-function relationships in the cell. In addition to the reports of original research, the journal publishes state of the art reviews. Specific subjects covered by Molecular and Cellular Biochemistry include cellular metabolism, cellular pathophysiology, enzymology, ion transport, lipid biochemistry, membrane biochemistry, molecular biology, nuclear structure and function, and protein chemistry.