{"title":"孟德尔随机试验揭示血清铜作为一种微量营养素是勃起功能障碍的风险因素","authors":"Wu Wensong, Yu Qianqian, Aisha Awuti, Chang Fan, Chen Fangmin","doi":"10.1007/s12011-024-04377-0","DOIUrl":null,"url":null,"abstract":"<p>The cause and effect between serum micronutrients and erectile dysfunction (ED) is not clear. The purpose of this study was to evaluate the causal relationship between micronutrients and ED by Mendelian randomization (MR) analysis. We used the published genome-wide association study (GWAS) data for two-sample MR analysis. This study utilized inverse variance weighted (IVW), MR egger, weighted median, simple mode, and weighted mode method to assess the causal relationship between serum micronutrients and ED. IVW is considered the standard method for MR analysis. We used Cochran’s <i>Q</i> tests to evaluate the heterogeneity. To investigate horizontal pleiotropy, this study employed the MR Egger method. Additionally, leave-one-out analysis was used to evaluate the influence of individual genetic loci on the results. The results showed that there was a causal relationship between serum copper and ED, and it was positively correlated with ED (OR = 1.115, CI = 1.00–1.24, <i>p</i> = 0.014). There was no significant correlation between other micronutrients and ED. Sensitivity analysis results indicated that our findings exhibit no heterogeneity or pleiotropy, thereby strengthening our conclusions. Serum copper is a risk factor for ED, which provides a new idea for the diagnosis and treatment of ED in the future. However, further experiments are needed to elucidate the underlying mechanisms.</p>","PeriodicalId":8917,"journal":{"name":"Biological Trace Element Research","volume":null,"pages":null},"PeriodicalIF":3.4000,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Mendelian Randomization Reveals Serum Copper as a Micronutrient is a Risk Factor for Erectile Dysfunction\",\"authors\":\"Wu Wensong, Yu Qianqian, Aisha Awuti, Chang Fan, Chen Fangmin\",\"doi\":\"10.1007/s12011-024-04377-0\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>The cause and effect between serum micronutrients and erectile dysfunction (ED) is not clear. The purpose of this study was to evaluate the causal relationship between micronutrients and ED by Mendelian randomization (MR) analysis. We used the published genome-wide association study (GWAS) data for two-sample MR analysis. This study utilized inverse variance weighted (IVW), MR egger, weighted median, simple mode, and weighted mode method to assess the causal relationship between serum micronutrients and ED. IVW is considered the standard method for MR analysis. We used Cochran’s <i>Q</i> tests to evaluate the heterogeneity. To investigate horizontal pleiotropy, this study employed the MR Egger method. Additionally, leave-one-out analysis was used to evaluate the influence of individual genetic loci on the results. The results showed that there was a causal relationship between serum copper and ED, and it was positively correlated with ED (OR = 1.115, CI = 1.00–1.24, <i>p</i> = 0.014). There was no significant correlation between other micronutrients and ED. Sensitivity analysis results indicated that our findings exhibit no heterogeneity or pleiotropy, thereby strengthening our conclusions. Serum copper is a risk factor for ED, which provides a new idea for the diagnosis and treatment of ED in the future. However, further experiments are needed to elucidate the underlying mechanisms.</p>\",\"PeriodicalId\":8917,\"journal\":{\"name\":\"Biological Trace Element Research\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":3.4000,\"publicationDate\":\"2024-09-18\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Biological Trace Element Research\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://doi.org/10.1007/s12011-024-04377-0\",\"RegionNum\":3,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"BIOCHEMISTRY & MOLECULAR BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biological Trace Element Research","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1007/s12011-024-04377-0","RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
引用次数: 0
摘要
血清微量营养素与勃起功能障碍(ED)之间的因果关系尚不明确。本研究的目的是通过孟德尔随机分析法(MR)评估微量营养素与勃起功能障碍之间的因果关系。我们利用已发表的全基因组关联研究(GWAS)数据进行了双样本 MR 分析。本研究采用了反方差加权法(IVW)、MR egger法、加权中位法、简单模式法和加权模式法来评估血清微量营养素与ED之间的因果关系。IVW被认为是MR分析的标准方法。我们使用 Cochran's Q 检验来评估异质性。为了研究横向多效性,本研究采用了 MR Egger 方法。此外,我们还使用了 "leave-one-out "分析来评估单个遗传位点对结果的影响。结果显示,血清铜与 ED 之间存在因果关系,且与 ED 呈正相关(OR = 1.115,CI = 1.00-1.24,P = 0.014)。其他微量营养素与 ED 之间无明显相关性。敏感性分析结果表明,我们的研究结果不存在异质性或多义性,从而加强了我们的结论。血清铜是ED的一个危险因素,这为今后诊断和治疗ED提供了一个新思路。然而,要阐明其潜在机制还需要进一步的实验。
Mendelian Randomization Reveals Serum Copper as a Micronutrient is a Risk Factor for Erectile Dysfunction
The cause and effect between serum micronutrients and erectile dysfunction (ED) is not clear. The purpose of this study was to evaluate the causal relationship between micronutrients and ED by Mendelian randomization (MR) analysis. We used the published genome-wide association study (GWAS) data for two-sample MR analysis. This study utilized inverse variance weighted (IVW), MR egger, weighted median, simple mode, and weighted mode method to assess the causal relationship between serum micronutrients and ED. IVW is considered the standard method for MR analysis. We used Cochran’s Q tests to evaluate the heterogeneity. To investigate horizontal pleiotropy, this study employed the MR Egger method. Additionally, leave-one-out analysis was used to evaluate the influence of individual genetic loci on the results. The results showed that there was a causal relationship between serum copper and ED, and it was positively correlated with ED (OR = 1.115, CI = 1.00–1.24, p = 0.014). There was no significant correlation between other micronutrients and ED. Sensitivity analysis results indicated that our findings exhibit no heterogeneity or pleiotropy, thereby strengthening our conclusions. Serum copper is a risk factor for ED, which provides a new idea for the diagnosis and treatment of ED in the future. However, further experiments are needed to elucidate the underlying mechanisms.
期刊介绍:
Biological Trace Element Research provides a much-needed central forum for the emergent, interdisciplinary field of research on the biological, environmental, and biomedical roles of trace elements. Rather than confine itself to biochemistry, the journal emphasizes the integrative aspects of trace metal research in all appropriate fields, publishing human and animal nutritional studies devoted to the fundamental chemistry and biochemistry at issue as well as to the elucidation of the relevant aspects of preventive medicine, epidemiology, clinical chemistry, agriculture, endocrinology, animal science, pharmacology, microbiology, toxicology, virology, marine biology, sensory physiology, developmental biology, and related fields.