内源性μ-阿片对人类社会联系的调节:系统回顾和荟萃分析

IF 5.8 1区 医学 Q1 PSYCHIATRY Translational Psychiatry Pub Date : 2024-09-17 DOI:10.1038/s41398-024-03088-3
Guro Løseth, Martin Trøstheim, Siri Leknes
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引用次数: 0

摘要

在非人类哺乳动物中,对所有社会性物种的健康和生存都至关重要的社会联系依赖于μ-阿片信号。越来越多的神经影像学和精神药理学文献也表明,μ-阿片类药物与人类的社会联系有关。为了确定μ-阿片类药物在健康人的社会联系中的作用,我们对随机双盲安慰剂对照阿片类拮抗剂研究进行了预先登记(https://osf.io/x5wmq)的多层次随机效应荟萃分析。我们从 2023 年 10 月 12 日在 Web of Science、Scopus、PubMed 和 EMBASE 中进行的最终文献检索以及社区贡献中获得了 8 篇出版物和 2 个未发表项目的数据,共计 17 项结果(N = 455)。所有研究都使用纳曲酮(25-100 毫克)来阻断μ-阿片系统,并通过自我报告来测量社会联系。阿片类药物拮抗略微降低了社会联系感(Hedges' g [95% CI) = -0.20] [-0.32, -0.07] 。[-0.32, -0.07].研究内部和研究之间的结果高度一致(I2 = 23%)。然而,有迹象表明,在较小的研究中存在偏向于较大效应的偏倚(Egger 检验:B = -2.16,SE = 0.93,z = -2.33,p = 0.02),发表偏倚分析表明,纳曲酮的效应可能被高估。研究结果清楚地表明,完整的μ-阿片信号并不是体验社会连通性的必要条件,因为即使在完全药物阻断μ-阿片的情况下,也能明显感受到强烈的连通性。然而,拮抗剂降低了社会联系的测量结果,这与μ-阿片类药物对人类社会联系的调节作用是一致的。相对于非人类动物的研究结果,纳曲酮的影响范围不大,这可能与测量方法的差异(人类的主观反应与动物的行为/动机指数)、特定物种的神经机制或纳曲酮对其他阿片受体亚型的影响有关。总之,这些结果有助于解释μ-阿片调节失调和社会脱节是如何导致残疾的,反之,社会联系又是如何缓冲不良健康风险的。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Endogenous mu-opioid modulation of social connection in humans: a systematic review and meta-analysis

Social bonding, essential for health and survival in all social species, depends on mu-opioid signalling in non-human mammals. A growing neuroimaging and psychopharmacology literature also implicates mu-opioids in human social connectedness. To determine the role of mu-opioids for social connectedness in healthy humans, we conducted a preregistered (https://osf.io/x5wmq) multilevel random-effects meta-analysis of randomised double-blind placebo-controlled opioid antagonist studies. We included data from 8 publications and 2 unpublished projects, totalling 17 outcomes (N = 455) sourced from a final literature search in Web of Science, Scopus, PubMed and EMBASE on October 12, 2023, and through community contributions. All studies used naltrexone (25–100 mg) to block the mu-opioid system and measured social connectedness by self-report. Opioid antagonism slightly reduced feelings of social connectedness (Hedges’ g [95% CI) = −0.20] [−0.32, −0.07]. Results were highly consistent within and between studies (I2 = 23%). However, there was some indication of bias in favour of larger effects among smaller studies (Egger’s test: B = −2.16, SE = 0.93, z = −2.33, p = 0.02), and publication bias analysis indicated that the effect of naltrexone might be overestimated. The results clearly demonstrate that intact mu-opioid signalling is not essential for experiencing social connectedness, as robust feelings of connectedness are evident even during full pharmacological mu-opioid blockade. Nevertheless, antagonism reduced measures of social connection, consistent with a modulatory role of mu-opioids for human social connectedness. The modest effect size relative to findings in non-human animals, could be related to differences in measurement (subjective human responses versus behavioural/motivation indices in animals), species specific neural mechanisms, or naltrexone effects on other opioid receptor subtypes. In sum, these results help explain how mu-opioid dysregulation and social disconnection can contribute to disability, and conversely—how social connection can buffer risk of ill health.

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来源期刊
CiteScore
11.50
自引率
2.90%
发文量
484
审稿时长
23 weeks
期刊介绍: Psychiatry has suffered tremendously by the limited translational pipeline. Nobel laureate Julius Axelrod''s discovery in 1961 of monoamine reuptake by pre-synaptic neurons still forms the basis of contemporary antidepressant treatment. There is a grievous gap between the explosion of knowledge in neuroscience and conceptually novel treatments for our patients. Translational Psychiatry bridges this gap by fostering and highlighting the pathway from discovery to clinical applications, healthcare and global health. We view translation broadly as the full spectrum of work that marks the pathway from discovery to global health, inclusive. The steps of translation that are within the scope of Translational Psychiatry include (i) fundamental discovery, (ii) bench to bedside, (iii) bedside to clinical applications (clinical trials), (iv) translation to policy and health care guidelines, (v) assessment of health policy and usage, and (vi) global health. All areas of medical research, including — but not restricted to — molecular biology, genetics, pharmacology, imaging and epidemiology are welcome as they contribute to enhance the field of translational psychiatry.
期刊最新文献
Naltrexone blocks alcohol-induced effects on kappa-opioid receptors in the plasma membrane. Shared genetic architecture and causality between autism spectrum disorder and irritable bowel syndrome, multisite pain, and fatigue. Oral fungal dysbiosis and systemic immune dysfunction in Chinese patients with schizophrenia. Sertraline modulates hippocampal plasticity via sigma 1 receptors, cellular stress and neurosteroids. A computational signature of self-other mergence in Borderline Personality Disorder.
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