研究颈动脉斑块的蛋白质组分析最新进展

Q3 Medicine JVS-vascular science Pub Date : 2024-01-01 DOI:10.1016/j.jvssci.2024.100215
Gabriel Cruz-González MD , James F. Meschia MD , Benjamin J. Madden BSc , Mercedes Prudencio PhD , Camilo A. Polania-Sandoval MD , Janelle Hartwell BS , Eniola Oyefeso BS , Ranya Benchaaboune , Tara Brigham MLIS , Sukhwinder J.S. Sandhu MD , Cristine Charlesworth PhD, MS , Ganesh P. Pujari MD , Leonard Petrucelli PhD , Akhilesh Pandey MD, PhD , Young Erben MD
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引用次数: 0

摘要

方法 我们对颈动脉疾病患者血清、血浆和斑块样本的蛋白质组学特征进行了系统性回顾。我们纳入了经同行评审的成人研究,并按照 PRISMA 指南进行了报告。我们采用纽卡斯尔-渥太华量表对纳入综述的文章的设计和内容质量进行了评估。结果我们纳入了六篇报道颈动脉粥样硬化患者血清、血浆或斑块样本中蛋白质表达的同行评议文章。其中三篇为单中心横断面研究,两篇为单中心病例对照研究,一篇为单中心队列研究。在比较健康受试者和颈动脉血管病变患者的样本以及有症状和无症状颈动脉粥样硬化病变患者的样本时,发现有 36 种蛋白质的表达存在差异。其中一些被证明与动脉粥样硬化发生过程中的炎症或抗炎途径有关。研究发现,CD5L和S100A12在不稳定斑块患者中均上调,前者是由于其抗炎特性,后者则是由于其在动脉粥样硬化中的促氧化作用。结论动脉粥样硬化性颈动脉疾病增加了患者发生缺血性神经事件的风险。蛋白质组学有助于了解其病理生理过程,并能识别健康人和颈动脉斑块患者血液样本中不同的蛋白质表达。这种以患者为中心的方法可以及时发现中风风险较高的人群。
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Recent advances in proteomic analysis to study carotid artery plaques

Objective

We sought to identify differentially expressed proteins in serum, plasma, and plaque samples of patients with carotid atherosclerotic lesions.

Methods

We performed a systematic review of the proteomic profile of serum, plasma, and plaque samples of patients with carotid artery disease. We included full-length peer-reviewed studies of adult humans and reported them using PRISMA guidelines. The quality of the design and content of the articles included in the review was assessed using the Newcastle-Ottawa scale.

Results

We included six peer-reviewed articles reporting protein expression in serum, plasma, or plaque samples from patients with carotid atherosclerosis. Three were single-center cross-sectional studies, two were single-center case-control studies, and one was a single-center cohort study. Thirty-six proteins were found to be expressed differentially when comparing samples from healthy subjects and individuals with diseased carotid vessels and between patients with symptomatic and asymptomatic carotid artery atherosclerotic lesions. Some of these were shown to be related to inflammatory or anti-inflammatory pathways in atherogenesis. CD5L and S100A12 were both found to be upregulated in patients with unstable plaque, the former owing to its anti-inflammatory properties and the latter for its pro-oxidant effects in atherosclerosis. ACTB is involved in cellular structure and integrity and was found to be downregulated in patients with ruptured carotid plaques.

Conclusions

Atherosclerotic carotid disease places the patient at increased risk of ischemic neurological events. Proteomics may help to understand their pathophysiological processes and can identify differential protein expression in blood samples from healthy subjects and patients with carotid artery plaques. This patient-centered approach will allow for the timely identification of individuals at higher risk of experiencing stroke.

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来源期刊
CiteScore
4.20
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审稿时长
28 weeks
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