临床试验设计中的肾功能轨迹：挑战与机遇

IF 14.8 1区医学 Q1 UROLOGY & NEPHROLOGY Kidney international Pub Date : 2024-09-18 DOI:10.1016/j.kint.2024.07.023

Steven Rosansky , Richard Glassock

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引用次数: 0

摘要

作为新药试验替代终点的肾功能随时间推移的变化因多种因素而变得复杂，其中包括开始使用新药时估计肾小球滤过率的最初预期下降。该杂志的两篇文章探讨了这一难题，本评论还探讨了其他多个难题。昂贵的新药可能会延缓肾功能的衰退，为了最大限度地利用这些新药，这些药物应该留给那些肾功能极有可能迅速衰退的患者。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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The renal function trajectory in clinical trial design: challenges and opportunities

The changes in renal function over time as surrogate endpoints for new drug trials are complicated by many factors, including the often-expected initial decrease in estimated glomerular filtration rate when a new drug is started. Two articles in the journal address this challenge, but multiple other challenges are explored in this commentary. To maximize the benefits of expensive new drugs that may slow decline in renal function, these drugs should be reserved for those patients who have a high probability of rapid loss of kidney function.

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来源期刊

Kidney international 医学-泌尿学与肾脏学

CiteScore

23.30

自引率

3.10%

发文量

490

审稿时长

3-6 weeks

期刊介绍： Kidney International (KI), the official journal of the International Society of Nephrology, is led by Dr. Pierre Ronco (Paris, France) and stands as one of nephrology's most cited and esteemed publications worldwide. KI provides exceptional benefits for both readers and authors, featuring highly cited original articles, focused reviews, cutting-edge imaging techniques, and lively discussions on controversial topics. The journal is dedicated to kidney research, serving researchers, clinical investigators, and practicing nephrologists.

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