医疗补助扩展前后咽癌延迟治疗的性别和婚姻差异

Jason Semprini
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引用次数: 0

摘要

目标在美国,咽癌已成为最常见的头颈部癌症,其中 80% 的病例为男性。虽然在咽部患者中已经观察到了治疗延迟的差异,但对政策如何促进及时治疗却知之甚少。本研究旨在估算医疗补助(Medicaid)扩展与咽癌治疗延迟启动之间的关联。方法我们提取了监测、流行病学、最终结果(SEER)病例数据,分析2000年至2018年间诊断出的咽癌。相关结果是一个二进制变量,表示患者是否在确诊后两个月或两个月以上开始治疗。我们按照性别、婚姻状况和接受的治疗类型(手术、放疗、化疗、术后放疗、全身治疗)进行了亚组分析。我们采用了矩阵完成算法,以便在差分设计中考虑到医疗补助扩展的交错推出。在接受系统治疗的已婚女性中,延迟治疗的比例最低(5%),而在不建议接受手术治疗的已婚男性和女性中,延迟治疗的比例最高(43%)。总体而言,医疗补助计划的扩大与延迟治疗的变化之间没有关联。分组分析表明,在接受系统治疗的未婚女性(-4.5%-points)、接受化疗的已婚男性(Est. = -2.6%-points)、接受放疗的已婚男性(Est. = -3.1%-points)和不建议接受手术的已婚男性(Est. = -4.6%-points)中,医疗补助计划的扩大与治疗延迟的减少有关。
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Sex & marital differences in delayed pharyngeal cancer treatment before and after medicaid expansion

Objective

In the United States, pharyngeal cancer has become the most common type of head and neck cancer, with 80 % of cases found in males. Although disparities in treatment delays have been observed in pharyngeal patients, less is known about how policies facilitate timely care. This study aimed to estimate the association between Medicaid expansion and delaying initiation of pharyngeal cancer treatment.

Methodology

We extracted Surveillance, Epidemiological, End Results (SEER) case data to analyze pharyngeal cancers diagnosed between 2000 and 2018. The outcome of interest was a binary variable indicating if the patient initiated treatment two or more months after diagnosis. We conducted subgroup analyses by sex, marital status, and type of treatment received (surgery, radiation, chemotherapy, post-operative radiation, systemic therapy). We implemented the Matrix Completion algorithm to account for staggered rollout of Medicaid expansion within our difference-in-differences design.

Results

Our sample included 79,433 patients diagnosed with pharynx cancer. Delayed treatment was lowest among married females receiving systemic therapy (5 %), and highest among married males and females not recommended to receive surgery (43 %). Generally, there was no association between Medicaid expansion and changes in delayed treatment. Subgroup analyses show that Medicaid expansion was associated with reduced treatment delays in unmarried females receiving systemic therapy (−4.5%-points), and married males receiving chemotherapy (Est. = −2.6%-points), radiotherapy (Est. = −3.1%-points), and married males not recommended to receive surgery (Est. = −4.6%-points).

Conclusions

Given the importance of timely pharyngeal cancer treatment, health systems must identify and address the drivers of treatment delays to advance cancer equity.

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