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引用次数: 0
摘要
目的研究血小板与淋巴细胞比值（PLR）、中性粒细胞与淋巴细胞比值（NLR）以及急性生理学和慢性健康评估 II（APACHE II）评分与老年慢性阻塞性肺疾病（COPD）和呼吸衰竭患者预后的相关性：对 110 名患有呼吸衰竭的老年 COPD 患者进行了回顾性分析。收集了患者的一般信息、炎症指数（PLR、NLR）和肺功能评分。采用 t 检验和卡方检验进行统计比较。ROC曲线分析评估了调查变量的预测价值：结果：与预后良好组相比，预后不良组的 PLR、NLR 水平以及 COPD 评估测试（CAT）和 APACHE II 评分均明显较高。逻辑回归分析发现，PLR、NLR 和 APACHE II 评分是 COPD 呼吸衰竭患者的独立预后风险因素。ROC 曲线分析证实了这些变量在预测预后方面的高预测价值：结论：PLR、NLR 和 APACHE II 评分与老年慢性阻塞性肺病呼吸衰竭患者的预后相关，可作为患者预后的重要生物标志物。
Correlations of platelet-to-lymphocyte ratio, neutrophil-to-lymphocyte ratio and acute physiology, and chronic health evaluation II score with prognosis of elderly patients with chronic obstructive pulmonary disease and respiratory failure.
Objective: To investigate the correlations of platelet-to-lymphocyte ratio (PLR), neutrophil-to-lymphocyte ratio (NLR) and acute physiology and chronic health evaluation II (APACHE II) score with the prognosis of elderly patients with chronic obstructive pulmonary disease (COPD) and respiratory failure.
Methods: A retrospective analysis was conducted on 110 elderly COPD patients with respiratory failure. General information, inflammatory indices (PLR, NLR), and pulmonary function scores were collected. Statistical comparisons were made using t-tests and chi-square tests. ROC curve analysis evaluated the predictive value of the investigated variables.
Results: Compared to the good-prognosis group, the poor-prognosis group exhibited significantly higher PLR, NLR levels, as well as higher COPD Assessment Test (CAT) and APACHE II scores. Logistic regression analysis identified PLR, NLR, and APACHE II scores as independent prognostic risk factors for COPD patients with respiratory failure. ROC curve analysis confirmed the high predictive value of these variables in forecasting prognosis.
Conclusion: PLR, NLR, and APACHE II scores, exhibiting correlations with prognosis in elderly COPD patients with respiratory failure, can serve as valuable biomarkers for patient prognosis.
期刊介绍：
Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance.
Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
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