西班牙裔肝细胞癌患者的祖籍、飞地居住地和社会经济地位的预后意义。

IF 3.4 2区 医学 Q2 ONCOLOGY Annals of Surgical Oncology Pub Date : 2024-12-01 Epub Date: 2024-09-21 DOI:10.1245/s10434-024-15761-4
Zachary A Whitham, Nicole M Nevarez, Rong Rong, Gloria Chang, Cecilia G Ethun, Matthew R Porembka, John C Mansour, Sam C Wang, Patricio M Polanco, Herbert J Zeh, Nicole E Rich, Amit G Singal, Adam C Yopp
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引用次数: 0

摘要

背景:在西班牙裔癌症患者中,居住在民族飞地和本土性都与生存有关,但它们对肝细胞癌(HCC)患者的预后意义尚不清楚。我们旨在确定西班牙裔 HCC 患者的原籍地、邻里社会经济地位(nSES)和飞地居住地与总生存率之间的关系。方法:在德克萨斯州癌症登记处确定了 2004 年至 2017 年诊断为 HCC 的西班牙裔患者。将现有指数应用于2000年美国人口普查数据的区级,以衡量飞地居住地和nSES。飞地由七种测量方法定义。采用多变量考克斯比例危险模型评估原籍、飞地居住地和nSES与生存的关系:在9496名患有HCC的西班牙裔患者中,有2283人(24%)在国外出生。与美国出生的西语裔患者相比,外国出生的西语裔患者出现局部 HCC 的几率较低(45.3% 对 48.8%,P = 0.03),接受 HCC 治疗的几率也较低(53.9% 对 47.6%,P 结论:在西语裔 HCC 患者中,外国出生的西语裔患者存活率较高:在患有 HCC 的西班牙裔患者中,外国出生地和较高的 nSES(而非飞地居住地)与生存率的提高有关。有必要对种族、出生地和社区环境之间的交叉性进行进一步研究。
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The Prognostic Significance of Nativity, Enclave Residence, and Socioeconomic Status Among Hispanic Patients with Hepatocellular Carcinoma.

Background: Residence in ethnic enclaves and nativity are both associated with survival in Hispanic patients with cancer, although their prognostic significance in patients with hepatocellular carcinoma (HCC) is unknown. We aimed to determine the association between nativity, neighborhood socioeconomic status (nSES), and ethnic enclave residency with overall survival in Hispanic patients with HCC.

Methods: Hispanic patients diagnosed with HCC from 2004 to 2017 were identified in the Texas Cancer Registry. Existing indices were applied to tract-level 2000 US Census data to measure enclave residence and nSES. Enclaves were defined by seven measures. Multivariable Cox proportional hazard models were used to evaluate the association between nativity, enclave residency, and nSES with survival.

Results: Among 9496 Hispanic patients with HCC, 2283 (24%) were foreign-born. Compared with US-born Hispanic patients, foreign-born Hispanic patients were less likely to present with localized HCC (45.3% vs. 48.8%, p = 0.03) and less likely to receive HCC treatment (53.9% vs. 47.6%, p < 0.001); however, foreign-born Hispanic patients had lower mortality in adjusted models (adjusted hazard ratio [aHR] 0.86, 95% confidence interval [CI] 0.79-0.93). Neighborhood SES, but not enclave residence, was also associated with overall survival. Compared with those in low nSES non-enclaves, Hispanic patients in high nSES neighborhoods, with either enclave (aHR 0.80, 95% CI 0.72-0.88) or non-enclave (aHR 0.89, 95% CI 0.80-0.98) residence status and low nSES enclaves (aHR 0.93, 95% CI 0.86-0.98) had improved survival.

Conclusion: In Hispanic patients with HCC, foreign birthplace and higher nSES, but not enclave residence, are associated with improved survival. Additional research on intersectionality between ethnicity, nativity, and neighborhood context is warranted.

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来源期刊
CiteScore
5.90
自引率
10.80%
发文量
1698
审稿时长
2.8 months
期刊介绍: The Annals of Surgical Oncology is the official journal of The Society of Surgical Oncology and is published for the Society by Springer. The Annals publishes original and educational manuscripts about oncology for surgeons from all specialities in academic and community settings.
期刊最新文献
Correction: The Top Ten Annals of Surgical Oncology Original Articles on Twitter/X: 2020-2023. Correction: ASO Author Reflections: Minimally Invasive Surgery, Three-Dimensional (3D) Reconstruction and Indocyanine Green Fluorescence: The Perfect Combo to Enter the Era of Intraoperative Liver Navigation. Correction: Patient-Reported Outcomes 10 Years After Breast-Conserving Surgery for Early-Stage Breast Cancer. ASO Visual Abstract: Evaluating the Efficacy of Different Treatment Intensities in Nasopharyngeal Carcinoma Patients: A Nationwide Cancer Registry-Based Study. ASO Visual Abstract: Cost-Analysis of Pelvic Exenteration Surgery for Advanced Pelvic Malignancy.
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