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Laparoscopic Parenchymal-Sparing Hepatectomy with Middle Hepatic Vein Resection and Reconstruction for Colorectal Liver Metastases: A Video Case Report. 腹腔镜肝实质保留肝切除术与肝中静脉切除和重建术治疗结直肠肝转移瘤:视频病例报告。
IF 3.4 2区 医学 Q2 ONCOLOGY Pub Date : 2024-12-01 Epub Date: 2024-08-23 DOI: 10.1245/s10434-024-16063-5
Yi Ting Lin, Tiing Foong Siow, Alvin Yong Hui Tan, Ian Chik, Kuo Hsin Chen
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引用次数: 0
ASO Author Reflections: Hepatic Resection as the Primary Treatment Modality for Hepatocellular Carcinoma After Orthotopic Liver Transplantation. ASO 作者反思:将肝切除作为原位肝移植后肝细胞癌的主要治疗方式。
IF 3.4 2区 医学 Q2 ONCOLOGY Pub Date : 2024-12-01 Epub Date: 2024-09-14 DOI: 10.1245/s10434-024-16237-1
Abraham J Matar, Kailey M Oppat, Frances J Bennett, Emilie A K Warren, Chase J Wehrle, Zhihao Li, Luckshi Rajendran, Zachary P Rokop, Chandrashekhar Kubal, Ben E Biesterveld, David P Foley, Mayumi Maeda, Mindie H Nguyen, Beth Elinoff, Abhinav Humar, Dimitrios Moris, Debra Sudan, John Klein, Juliet Emamaullee, Vatche Agopian, Parsia A Vagefi, Shukri H A Dualeh, Christopher J Sonnenday, Gonzalo Sapisochin, Federico N Aucejo, Shishir K Maithel
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引用次数: 0
Adult Prostate Sarcoma: Demographics, Treatment Patterns, and Survival. 成人前列腺肉瘤:人口统计学、治疗模式和生存率。
IF 3.4 2区 医学 Q2 ONCOLOGY Pub Date : 2024-12-01 Epub Date: 2024-09-23 DOI: 10.1245/s10434-024-16258-w
Carolin Siech, Mario de Angelis, Francesco Di Bello, Natali Rodriguez Peñaranda, Jordan A Goyal, Zhe Tian, Fred Saad, Shahrokh F Shariat, Stefano Puliatti, Nicola Longo, Alberto Briganti, Séverine Banek, Philipp Mandel, Luis A Kluth, Felix K H Chun, Pierre I Karakiewicz

Background: This study aimed to examine clinicopathologic characteristics, treatment patterns, and survival rates in a contemporary population-based cohort of adult prostate sarcoma patients.

Methods: In the Surveillance, Epidemiology, and End Results database (2004-2020), adult patients with prostate sarcoma were identified. Descriptive statistics, Kaplan-Meier analyses, smoothed cumulative incidence plots, and Cox regression models were used.

Results: Of 125 patients, 45 (36%) harbored leiomyosarcoma, 17 (14%) had rhabdomyosarcoma, 15 (12%) had stromal sarcoma, 17 (14%) had sarcoma not otherwise specified (NOS), and 31 (25%) had other sarcoma subtypes. Metastatic stage was most common in the rhabdomyosarcoma patients (44%) and least common in the leiomyosarcoma (21%) and stromal sarcoma (20%) patients. Most of the rhabdomyosarcoma patients received the combination of systemic and radiation therapy with (24%) or without radical surgery (35%), whereas most of the leiomyosarcoma and stromal sarcoma patients underwent radical surgery with (22 and 13%) or without (22 and 47%) radiation. In the overall population, the median overall survival was 27 months. The 5-years overall versus cancer-specific versus other-cause mortality rates were respectively 71 versus 58 versus 13%. In the multivariable Cox regression models, the highest overall mortality was exhibited by the patients with metastatic disease (hazard ratio [HR] 2.87; 95% confidence interval [CI] 1.55-5.31; p < 0.001) or unknown disease stage (HR 2.94; 95% CI 2.20-7.21; p = 0.019). Conversely, of all the histologic subtypes, only stromal sarcoma distinguished itself by lower overall mortality (HR 0.41; 95% CI 0.18-0.96; p = 0.039).

Conclusions: Four major histologic subtypes were identified. Among most adult sarcoma patients, treatment patterns vary according to histology, from multimodal therapy to radical prostatectomy alone. These treatment differences reflect equally important heterogeneity in survival patterns.

背景:本研究旨在研究当代人群中成年前列腺肉瘤患者的临床病理特征、治疗模式和生存率:本研究旨在研究当代基于人群的成年前列腺肉瘤患者队列的临床病理特征、治疗模式和存活率:方法:在监测、流行病学和最终结果数据库(2004-2020 年)中确定了成年前列腺肉瘤患者。使用了描述性统计、卡普兰-梅耶分析、平滑累积发病率图和 Cox 回归模型:在125名患者中,45人(36%)罹患横纹肌肉瘤,17人(14%)罹患横纹肌肉瘤,15人(12%)罹患间质肉瘤,17人(14%)罹患未另作说明的肉瘤(NOS),31人(25%)罹患其他亚型肉瘤。转移期在横纹肌肉瘤患者中最常见(44%),在亮肌肉瘤(21%)和间质肉瘤(20%)患者中最少见。大多数横纹肌肉瘤患者接受了全身治疗和放射治疗相结合的治疗(24%),或未接受根治性手术(35%),而大多数亮肌肉瘤和间质肉瘤患者接受了根治性手术,并接受了放射治疗(22%和 13%)或未接受放射治疗(22%和 47%)。总生存期的中位数为 27 个月。5年总死亡率、癌症特异性死亡率和其他原因死亡率分别为71%、58%和13%。在多变量考克斯回归模型中,转移性疾病(危险比 [HR] 2.87;95% 置信区间 [CI] 1.55-5.31;p < 0.001)或疾病分期不明(HR 2.94;95% CI 2.20-7.21;p = 0.019)患者的总死亡率最高。相反,在所有组织学亚型中,只有间质肉瘤的总体死亡率较低(HR 0.41;95% CI 0.18-0.96;P = 0.039):结论:研究发现了四种主要的组织学亚型。在大多数成人肉瘤患者中,治疗模式因组织学而异,从多模式治疗到单纯前列腺癌根治术。这些治疗差异反映出生存模式的异质性也同样重要。
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引用次数: 0
ASO Author Reflections: Breast-Conserving Surgery After Neoadjuvant Systemic Therapy for Early-Stage Breast Cancer: Quantitative Biomarkers and Disparities in the Precision-Medicine Era. ASO 作者反思:早期乳腺癌新辅助系统治疗后的保乳手术:精准医疗时代的定量生物标志物与差异。
IF 3.4 2区 医学 Q2 ONCOLOGY Pub Date : 2024-12-01 Epub Date: 2024-09-23 DOI: 10.1245/s10434-024-16265-x
Jincong Q Freeman, Dezheng Huo, Frederick M Howard

In this era of precision medicine, incorporating quantitative measures of estrogen receptor (ER)/progesterone receptor (PR)/Ki-67 expressions and genomic assays could more precisely identify neoadjuvant systemic therapy with the highest likelihood of response and tumor downstaging. In our recent study, we quantified the likelihood of achieving breast-conserving surgery (BCS vs. mastectomy) after neoadjuvant chemotherapy or endocrine therapy as a function of demographics, quantitative ER/PR/Ki-67 expressions, 21-gene recurrence scores, or 70-gene risk scores in early-stage, hormone receptor (HR)-positive/human epidermal growth factor receptor 2 (HER2)-negative breast cancer. Using the 2010-2020 National Cancer Database, we found that the BCS rate after neoadjuvant chemotherapy was higher among patients with high 21-gene recurrence scores, lower ER/PR expression, or higher Ki-67 expression. Most patients who received neoadjuvant endocrine therapy underwent BCS, which was mostly dependent on ER expression. Asian women were less likely than white women to undergo BCS after neoadjuvant treatments. Lack of health insurance was associated with lower odds of BCS in both neoadjuvant settings. Although our study provides insight into the associations of BCS with quantitative biomarkers at a single time point, several questions remain unanswered. With the evolving landscape of neoadjuvant therapies in development for HR-positive/HER2-negative breast cancer, ongoing work using quantitative biomarkers and genomic assay scores is needed to select the right neoadjuvant systemic therapy for the right patient. Given the increasing amount of data available at the time of breast cancer diagnosis, novel computational approaches are needed to integrate patient demographic and tumor-specific factors to predict the optimal treatment strategy and likelihood of BCS.

在这个精准医疗的时代,结合雌激素受体(ER)/孕激素受体(PR)/Ki-67表达的定量测量和基因组检测,可以更精确地确定最有可能产生反应和肿瘤降期的新辅助系统性疗法。在我们最近的研究中,我们量化了早期激素受体(HR)阳性/人表皮生长因子受体2(HER2)阴性乳腺癌患者在接受新辅助化疗或内分泌治疗后接受保乳手术(BCS vs. 乳房切除术)的可能性,并将其作为人口统计学、ER/PR/Ki-67定量表达、21基因复发评分或70基因风险评分的函数。利用 2010-2020 年全国癌症数据库,我们发现在 21 基因复发评分较高、ER/PR 表达较低或 Ki-67 表达较高的患者中,接受新辅助化疗后的 BCS 率较高。大多数接受新辅助内分泌治疗的患者都进行了BCS,这主要取决于ER的表达。与白人女性相比,亚裔女性在接受新辅助治疗后接受BCS的可能性较低。在两种新辅助治疗中,缺乏医疗保险与较低的BCS几率有关。尽管我们的研究深入探讨了 BCS 与单个时间点定量生物标志物的关系,但仍有几个问题没有得到解答。随着HR阳性/HER2阴性乳腺癌新辅助疗法的不断发展,我们需要不断利用定量生物标志物和基因组检测评分来为合适的患者选择合适的新辅助系统疗法。鉴于乳腺癌诊断时可获得的数据量不断增加,需要采用新型计算方法来整合患者人口统计学和肿瘤特异性因素,以预测最佳治疗策略和BCS的可能性。
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引用次数: 0
ASO Author Reflections: Can Artificial Intelligence Assist in the Recognition of Recurrent Laryngeal Nerve During Robot-Assisted Minimally Invasive Esophagectomy? ASO 作者的思考:人工智能能否帮助识别机器人辅助微创食管切除术中的复发性喉神经?
IF 3.4 2区 医学 Q2 ONCOLOGY Pub Date : 2024-12-01 Epub Date: 2024-09-29 DOI: 10.1245/s10434-024-16273-x
Tasuku Furube, Masashi Takeuchi, Hirofumi Kawakubo, Satoru Matsuda, Yuko Kitagawa
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引用次数: 0
ASO Author Reflections: Can Adequate Surgical Margin Rates after Mastectomy Be Improved? ASO 作者的思考:能否提高乳房切除术后的适当手术边缘率?
IF 3.4 2区 医学 Q2 ONCOLOGY Pub Date : 2024-12-01 Epub Date: 2024-10-12 DOI: 10.1245/s10434-024-16312-7
Nicolás Ajkay
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引用次数: 0
Correlation Between the Number of Pathological Risk Factors and Postoperative Prognosis in Patients with Stage I Lung Adenocarcinoma. 肺腺癌 I 期患者病理风险因素数量与术后预后之间的相关性
IF 3.4 2区 医学 Q2 ONCOLOGY Pub Date : 2024-12-01 Epub Date: 2024-08-19 DOI: 10.1245/s10434-024-16045-7
Junhong Liu, Bingji Cao, ZhiHua Shi, Xinbo Liu, Junfeng Liu

Background: Although visceral pleural invasion, lymphovascular invasion, tumor spread through air spaces, and poor differentiation are pathological risk factors associated with unfavorable prognosis in patients with lung adenocarcinoma, the cumulative impact of these factors on prognosis remains unclear.

Methods: We enrolled 1532 patients with stage I lung adenocarcinoma. Patients were divided according to the number of risk factors as follows: Group A (without risk factors), Group B (one risk factor), and Group C (multiple risk factors). Moreover, we stratified patients into two subgroups based on tumor size (≤ 3 cm, 3-4 cm). Kaplan-Meier analysis was used to evaluate 5-year disease-free survival (DFS) and overall survival (OS).

Results: Overall, 949, 404, and 179 patients were included in Groups A, B, and C, respectively. Group C had a larger tumor size and more cases of extrathoracic recurrence than the other groups. The 5-year DFS and OS gradually decreased across Groups A to C (DFS: 94.3%, 80.6%, and 64.3%, respectively, p < 0.001; OS: 97.2%, 92.7%, and 77%, respectively, p < 0.001). A similar trend was observed for tumors ≤ 3 cm in size (DFS: 95.2%, 83.2%, and 68.5%, respectively, p < 0.001; OS: 97.6%, 94.1%, and 79.6%, respectively, p < 0.001), but a less pronounced trend was observed for tumors between 3 and 4 cm in size (DFS: 72.1, 60.8, and 43.3%, respectively, p = 0.054; OS: 85.7, 82.1, and 64.7%, respectively, p = 0.16).

Conclusions: Postoperative survival worsened with increasing pathological risk factors in patients with stage I lung adenocarcinoma, especially those with tumor size ≤ 3 cm.

背景:虽然内脏胸膜侵犯、淋巴管侵犯、肿瘤通过气隙扩散和分化不良是与肺腺癌患者预后不良相关的病理风险因素,但这些因素对预后的累积影响仍不清楚:我们招募了 1532 名 I 期肺腺癌患者。根据风险因素的数量将患者分为以下几组:A组(无危险因素)、B组(一个危险因素)和C组(多个危险因素)。此外,我们还根据肿瘤大小(≤ 3 厘米、3-4 厘米)将患者分为两个亚组。我们采用卡普兰-梅耶尔分析法评估患者的5年无病生存期(DFS)和总生存期(OS):A 组、B 组和 C 组患者分别为 949 人、404 人和 179 人。与其他组相比,C组肿瘤体积更大,胸外复发病例更多。A 组到 C 组的 5 年 DFS 和 OS 逐渐下降(DFS:分别为 94.3%、80.6% 和 64.3%,P,结论):I期肺腺癌患者的术后生存率随着病理危险因素的增加而恶化,尤其是肿瘤大小≤3厘米的患者。
{"title":"Correlation Between the Number of Pathological Risk Factors and Postoperative Prognosis in Patients with Stage I Lung Adenocarcinoma.","authors":"Junhong Liu, Bingji Cao, ZhiHua Shi, Xinbo Liu, Junfeng Liu","doi":"10.1245/s10434-024-16045-7","DOIUrl":"10.1245/s10434-024-16045-7","url":null,"abstract":"<p><strong>Background: </strong>Although visceral pleural invasion, lymphovascular invasion, tumor spread through air spaces, and poor differentiation are pathological risk factors associated with unfavorable prognosis in patients with lung adenocarcinoma, the cumulative impact of these factors on prognosis remains unclear.</p><p><strong>Methods: </strong>We enrolled 1532 patients with stage I lung adenocarcinoma. Patients were divided according to the number of risk factors as follows: Group A (without risk factors), Group B (one risk factor), and Group C (multiple risk factors). Moreover, we stratified patients into two subgroups based on tumor size (≤ 3 cm, 3-4 cm). Kaplan-Meier analysis was used to evaluate 5-year disease-free survival (DFS) and overall survival (OS).</p><p><strong>Results: </strong>Overall, 949, 404, and 179 patients were included in Groups A, B, and C, respectively. Group C had a larger tumor size and more cases of extrathoracic recurrence than the other groups. The 5-year DFS and OS gradually decreased across Groups A to C (DFS: 94.3%, 80.6%, and 64.3%, respectively, p < 0.001; OS: 97.2%, 92.7%, and 77%, respectively, p < 0.001). A similar trend was observed for tumors ≤ 3 cm in size (DFS: 95.2%, 83.2%, and 68.5%, respectively, p < 0.001; OS: 97.6%, 94.1%, and 79.6%, respectively, p < 0.001), but a less pronounced trend was observed for tumors between 3 and 4 cm in size (DFS: 72.1, 60.8, and 43.3%, respectively, p = 0.054; OS: 85.7, 82.1, and 64.7%, respectively, p = 0.16).</p><p><strong>Conclusions: </strong>Postoperative survival worsened with increasing pathological risk factors in patients with stage I lung adenocarcinoma, especially those with tumor size ≤ 3 cm.</p>","PeriodicalId":8229,"journal":{"name":"Annals of Surgical Oncology","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141999365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Laparoscopic Duodenum and Spleen-Preserving Subtotal or Total Pancreatectomy: A Parenchyma-Sparing Strategy for Main Duct Intraductal Papillary Mucinous Neoplasms (with Video). 腹腔镜十二指肠和脾脏保留次全或全胰切除术:主导管内乳头状黏液性肿瘤的实质保留策略(附视频)。
IF 3.4 2区 医学 Q2 ONCOLOGY Pub Date : 2024-12-01 Epub Date: 2024-09-23 DOI: 10.1245/s10434-024-16244-2
Zheng Li, Yihua Shi, Wenjie Tang, Chen Chen, Wensheng Liu, Qifeng Zhuo, Shunrong Ji, Chenjie Zhou, Xianjun Yu, Xiaowu Xu

Background: For premalignant main duct intraductal papillary mucinous neoplasms (MD-IPMN), laparoscopic duodenum and spleen-preserving subtotal or total pancreatectomy (LDSP-STP/TP) seems to be a viable option for parenchyma-sparing pancreatectomy.

Patients and methods: On the basis of the imaging features, family history, genomic alterations, intraoperative ultrasound examination, and frozen section evaluation, we have proposed patient selection strategies for the LDSP-STP/TP technique for the first time. Additionally, a comprehensive step-by-step overview of this technique has been provided. To date, we have performed five LDSP-STP procedures and one LDSP-TP procedure.

Results: We successfully performed selective resection of the affected pancreatic parenchyma while preserving the duodenum, common bile duct (CBD), spleen, and splenic artery and vein. The operation time ranged from 295 to 495 min, with blood loss ranging from 100 to 300 mL. Postoperative pathological results revealed low-grade dysplasia in the resected pancreatic samples and margins. The patients resumed eating within 3-5 days after surgery, and all postoperative complications were classified as grade I according to the Clavien-Dindo classification. At the 3-month follow-up, there were no cases of CBD ischemic stenosis, splenic ischemia, or pseudocyst formation observed. For patients who received LDSP-STP, the longitudinal diameter of the remaining pancreatic tail ranged from 2.2 to 4.6 cm, and they demonstrated satisfactory long-term blood glycemic control.

Conclusions: LDSP-STP/TP demonstrates technical feasibility and safety. It allows for the selective resection of the affected pancreatic parenchyma, thereby minimizing the impact of pancreatic functional impairment. However, it is crucial to validate this technique through long-term prospective observations.

背景:对于前恶性主导管内乳头状黏液瘤(MD-IPMN),腹腔镜十二指肠和脾脏保留次全或全胰腺切除术(LDSP-STP/TP)似乎是保留胰腺实质切除术的可行选择:根据影像学特征、家族史、基因组改变、术中超声检查和冰冻切片评估,我们首次提出了 LDSP-STP/TP 技术的患者选择策略。此外,我们还提供了该技术的全面步骤概述。迄今为止,我们已经实施了五例 LDSP-STP 手术和一例 LDSP-TP 手术:结果:我们成功地对受影响的胰腺实质进行了选择性切除,同时保留了十二指肠、胆总管(CBD)、脾脏、脾动静脉。手术时间为 295 至 495 分钟,失血量为 100 至 300 毫升。术后病理结果显示,切除的胰腺样本和边缘存在低度发育不良。患者在术后 3-5 天内恢复进食,根据 Clavien-Dindo 分级法,所有术后并发症均为 I 级。在 3 个月的随访中,没有发现 CBD 缺血性狭窄、脾脏缺血或假性囊肿形成的病例。接受LDSP-STP治疗的患者,剩余胰尾的纵向直径在2.2厘米至4.6厘米之间,长期血糖控制令人满意:结论:LDSP-STP/TP具有技术可行性和安全性。结论:LDSP-STP/TP 证明了技术的可行性和安全性,它可以选择性切除受影响的胰腺实质,从而将胰腺功能障碍的影响降至最低。然而,通过长期前瞻性观察来验证这项技术至关重要。
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引用次数: 0
Disappearing Signet Ring Cell Adenocarcinoma in Gastric Cancer Patients. 胃癌患者中消失的印戒细胞腺癌
IF 3.4 2区 医学 Q2 ONCOLOGY Pub Date : 2024-12-01 Epub Date: 2024-09-29 DOI: 10.1245/s10434-024-16117-8
Aravind Sreeram, Emily E Stroobant, Monika Laszkowska, Parry Guilford, Shoji Shimada, Makoto Nishimura, Sohrab Shah, Santosha Vardhana, Laura H Tang, Vivian E Strong

Background: The incidence of diffuse-type gastric cancer is increasing steadily in the United States, Europe, and Asia. This subtype is known for aggressive clinical characteristics and transmural invasion. However, T1a diffuse-type cancers have been observed to have a better 5-year, disease-specific mortality than stage-matched intestinal tumors, supporting a clinical difference in these early-stage cancers.

Methods: Data on all living patients with T1a gastric adenocarcinoma with a finding of signet ring cell morphology on pathology and ≥1 year of follow-up from 2013 to 2023 at Memorial Sloan Kettering Cancer Center (MSK) was collected from a prospectively maintained database. Patients with known CDH1 or CTNNA1 mutations were excluded.

Results: In 7 of 30 patients, sporadic pathologically confirmed T1a signet ring cell (diffuse) cancer identified on initial biopsy was no longer detectable upon subsequent biopsy or resection with mean follow-up of 50 months.

Conclusions: These cases allude to the distinct pathways of carcinogenesis in T1a signet ring cell cancers. Potential factors that may underlie the spontaneous regression of these T1a cancers include complete removal at initial biopsy, immune clearance, and lack of survival advantage conferred by signet ring cell genetic alterations in these cases. Given their more indolent behavior at an earlier stage, we suggest that these lesions can be closely followed by endoscopy in select circumstances with thorough disease assessment and an experienced care team.

背景:在美国、欧洲和亚洲,弥漫型胃癌的发病率正在稳步上升。众所周知,该亚型具有侵袭性临床特征和经壁浸润。然而,与分期匹配的肠道肿瘤相比,T1a弥漫型胃癌的5年疾病特异性死亡率较高,这支持了这些早期癌症的临床差异:斯隆-凯特琳纪念癌症中心(MSK)从前瞻性维护的数据库中收集了2013年至2023年所有在世的T1a胃腺癌患者的数据,这些患者在病理检查中发现了标志环细胞形态,且随访时间≥1年。已知CDH1或CTNNA1突变的患者被排除在外:30例患者中有7例经病理证实为散发性T1a标志环细胞(弥漫性)癌,在最初的活检中发现,在随后的活检或切除术中不再能检测到,平均随访时间为50个月:这些病例揭示了T1a标志环细胞癌的不同致癌途径。导致这些 T1a 癌症自发消退的潜在因素包括初次活检时完全切除、免疫清除,以及这些病例中的标志环细胞基因改变缺乏生存优势。鉴于这些病变在早期阶段表现较为懒散,我们建议在对疾病进行全面评估并由经验丰富的团队进行治疗的情况下,可以通过内窥镜对这些病变进行密切跟踪。
{"title":"Disappearing Signet Ring Cell Adenocarcinoma in Gastric Cancer Patients.","authors":"Aravind Sreeram, Emily E Stroobant, Monika Laszkowska, Parry Guilford, Shoji Shimada, Makoto Nishimura, Sohrab Shah, Santosha Vardhana, Laura H Tang, Vivian E Strong","doi":"10.1245/s10434-024-16117-8","DOIUrl":"10.1245/s10434-024-16117-8","url":null,"abstract":"<p><strong>Background: </strong>The incidence of diffuse-type gastric cancer is increasing steadily in the United States, Europe, and Asia. This subtype is known for aggressive clinical characteristics and transmural invasion. However, T1a diffuse-type cancers have been observed to have a better 5-year, disease-specific mortality than stage-matched intestinal tumors, supporting a clinical difference in these early-stage cancers.</p><p><strong>Methods: </strong>Data on all living patients with T1a gastric adenocarcinoma with a finding of signet ring cell morphology on pathology and ≥1 year of follow-up from 2013 to 2023 at Memorial Sloan Kettering Cancer Center (MSK) was collected from a prospectively maintained database. Patients with known CDH1 or CTNNA1 mutations were excluded.</p><p><strong>Results: </strong>In 7 of 30 patients, sporadic pathologically confirmed T1a signet ring cell (diffuse) cancer identified on initial biopsy was no longer detectable upon subsequent biopsy or resection with mean follow-up of 50 months.</p><p><strong>Conclusions: </strong>These cases allude to the distinct pathways of carcinogenesis in T1a signet ring cell cancers. Potential factors that may underlie the spontaneous regression of these T1a cancers include complete removal at initial biopsy, immune clearance, and lack of survival advantage conferred by signet ring cell genetic alterations in these cases. Given their more indolent behavior at an earlier stage, we suggest that these lesions can be closely followed by endoscopy in select circumstances with thorough disease assessment and an experienced care team.</p>","PeriodicalId":8229,"journal":{"name":"Annals of Surgical Oncology","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142340025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
ASO Author Refections: A Novel Prognostic Model Based on Muscle-Invasive Bladder Cancer Types. ASO 作者切除术:基于肌肉浸润性膀胱癌类型的新型预后模型
IF 3.4 2区 医学 Q2 ONCOLOGY Pub Date : 2024-12-01 Epub Date: 2024-10-07 DOI: 10.1245/s10434-024-16275-9
Shicong Lai, Jianyong Liu, Guan Zhang, Hao Hu, Tao Xu
{"title":"ASO Author Refections: A Novel Prognostic Model Based on Muscle-Invasive Bladder Cancer Types.","authors":"Shicong Lai, Jianyong Liu, Guan Zhang, Hao Hu, Tao Xu","doi":"10.1245/s10434-024-16275-9","DOIUrl":"10.1245/s10434-024-16275-9","url":null,"abstract":"","PeriodicalId":8229,"journal":{"name":"Annals of Surgical Oncology","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142379931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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Annals of Surgical Oncology
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