Netanel Golan, Rafael Y Brzezinski, Moaad Slieman, Shafik Khoury, Ofer Havakuk, Yan Topilsky, Shmuel Banai, Michal Laufer-Perl
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The primary endpoint was the prevalence of PAD and whether it correlates with LV dysfunction, defined by LV GLS absolute value < 19%. The secondary composite endpoint evaluated the association between reduced ABI to LV dysfunction and all-cause mortality.</p><p><strong>Results: </strong>Among 226 patients, PAD was diagnosed in 14 patients (6%). We revealed a positive correlation between ABI and LV GLS (r = 0.22, p < 0.01) with a reduced mean ABI score among patients with reduced LV GLS. A reduced mean ABI was observed among the positive composite endpoint group; however, it was not statistically significant (p = 0.35).</p><p><strong>Conclusions: </strong>We report, for the first time to our knowledge, the routine use of ABI testing among patients diagnosed with cancer. ABI showed a significant correlation to LV GLS, implying a potential tool in the early diagnosis of atherosclerosis and cardiotoxicity. 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引用次数: 0
摘要
背景:癌症治疗被认为会加速缺血。踝肱指数(ABI)测量是一种廉价、简单、可用于早期诊断外周动脉疾病(PAD)的检测方法;然而,它并不是常规检测方法。我们旨在评估常规 ABI 测量在诊断癌症患者 PAD 中的作用,以及它是否与左心室(LV)功能障碍相关:这是一项回顾性单中心研究,研究对象包括特拉维夫苏拉斯基医疗中心的癌症患者。研究对象包括进行常规 ABI 和左心室整体纵向应变 (GLS) 超声心动图检查的患者。主要终点是PAD的患病率以及它是否与左心室功能障碍(以左心室GLS绝对值定义)相关:在 226 名患者中,14 名患者(6%)被确诊为 PAD。我们发现 ABI 与 LV GLS 之间存在正相关(r = 0.22,p 结论:ABI 与 LV GLS 之间存在正相关:据我们所知,我们首次报告了在癌症患者中常规使用 ABI 检测的情况。ABI 与左心室 GLS 呈明显相关性,这意味着它是早期诊断动脉粥样硬化和心脏毒性的潜在工具。考虑到 ABI 的低成本和可用性,未来需要进行前瞻性试验,将其纳入常规评估中。
Routine Ankle-Brachial Index (ABI) measurement: a window into atherosclerosis and early left ventricular dysfunction in patients diagnosed with cancer.
Background: Cancer therapy is considered to cause accelerated ischemia. Ankle-Brachial Index (ABI) measurement is an inexpensive, simple, available test for the early diagnosis of peripheral artery disease (PAD); however, it is not performed routinely. We aimed to evaluate the role of routine ABI measurement for the diagnosis of PAD among patients diagnosed with cancer and whether it correlates with left ventricular (LV) dysfunction.
Methods: A retrospective, single-center study including patients diagnosed with cancer at Tel Aviv Sourasky Medical Center. The cohort included patients performing routine ABI and LV global longitudinal strain (GLS) echocardiography. The primary endpoint was the prevalence of PAD and whether it correlates with LV dysfunction, defined by LV GLS absolute value < 19%. The secondary composite endpoint evaluated the association between reduced ABI to LV dysfunction and all-cause mortality.
Results: Among 226 patients, PAD was diagnosed in 14 patients (6%). We revealed a positive correlation between ABI and LV GLS (r = 0.22, p < 0.01) with a reduced mean ABI score among patients with reduced LV GLS. A reduced mean ABI was observed among the positive composite endpoint group; however, it was not statistically significant (p = 0.35).
Conclusions: We report, for the first time to our knowledge, the routine use of ABI testing among patients diagnosed with cancer. ABI showed a significant correlation to LV GLS, implying a potential tool in the early diagnosis of atherosclerosis and cardiotoxicity. Considering its low cost and availability, future prospective trials are needed to integrate its role in routine assessment.