发作间期偏头痛患者的黄斑锥体功能与畏光之间缺乏直接联系。

IF 5 2区 医学 Q1 CLINICAL NEUROLOGY Cephalalgia Pub Date : 2024-09-01 DOI:10.1177/03331024241276501
Francesco Casillo, Antonio Di Renzo, Gabriele Sebastianelli, Chiara Abagnale, Francesco Martelli, Cherubino Di Lorenzo, Mariano Serrao, Benedetto Falsini, Vincenzo Parisi, Gianluca Coppola
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引用次数: 0

摘要

背景:恐光症的发病机制是与视觉皮层兴奋性的改变有关,还是与颜色相关的局灶性黄斑视网膜-丘脑信息处理的特定异常有关,目前仍有争议:这项横断面研究同时检查了一组有(n = 18)和无(n = 19)先兆的偏头痛患者在发作间期的Ganzfeld蓝-红(B-R)和蓝-黄(B-Y)局灶性黄斑锥体闪光ERG(ffERG)和局灶性闪光视觉诱发电位(ffVEPs),并与一组健康志愿者(HVs)(n = 20)进行了对比。我们将由此产生的视网膜和大脑皮层电生理反应与暴露在强光下的主观不适感相关联,并用数字量表进行验证:与 HVs 相比,无先兆偏头痛患者和有先兆偏头痛患者在 B-R 和 B-Y 局灶刺激下的 ffERG 和 ffVEPs 第一次和第二次谐波的振幅和相位无显著差异。皮尔逊相关性检验未发现临床变量(包括畏光量表)与电生理变量之间存在相关性:这些结果并不支持偏头痛患者的 L-M 锥体和 S 锥体对侧视觉通路在发作间期出现功能异常。结论:这些结果并不支持偏头痛患者L-M和S-锥体对视通路发作间期的功能异常,也表明暴露于强光导致的不适与局灶性黄斑视网膜至视觉皮层通路无关。
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Lack of a direct link between macular cones function and photophobia in interictal migraine.

Background: It is still debatable whether the mechanisms underlying photophobia are related to altered visual cortex excitability or specific abnormalities of colour-related focal macular retino-thalamic information processing.

Methods: This cross-sectional study examined Ganzfeld blue-red (B-R) and blue-yellow (B-Y) focal macular cone flash ERG (ffERG) and focal-flash visual evoked potentials (ffVEPs) simultaneously in a group of migraine patients with (n = 18) and without (n = 19) aura during the interictal phase, in comparison to a group of healthy volunteers (HVs) (n = 20). We correlate the resulting retinal and cortical electrophysiological responses with subjective discomfort from exposure to bright light verified on a numerical scale.

Results: Compared to HVs, the amplitude and phase of the first and second harmonic of ffERG and ffVEPs were non-significantly different in migraine patients without aura and migraine patients with aura for both the B-R and the B-Y focal stimuli. Pearson's correlation test did not disclose correlations between clinical variables, including the photophobia scale and electrophysiological variables.

Conclusions: These results do not favour interictal functional abnormalities in L-M- and S-cone opponent visual pathways in patients with migraine. They also suggest that the discomfort resulting from exposure to bright light is not related to focal macular retinal-to-visual cortex pathway.

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来源期刊
Cephalalgia
Cephalalgia 医学-临床神经学
CiteScore
10.10
自引率
6.10%
发文量
108
审稿时长
4-8 weeks
期刊介绍: Cephalalgia contains original peer reviewed papers on all aspects of headache. The journal provides an international forum for original research papers, review articles and short communications. Published monthly on behalf of the International Headache Society, Cephalalgia''s rapid review averages 5 ½ weeks from author submission to first decision.
期刊最新文献
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