生物类黄酮 "Daidzein":治疗见解、配方进展和未来方向。

IF 1.7 Q3 PHARMACOLOGY & PHARMACY Drug Research Pub Date : 2024-11-01 Epub Date: 2024-09-19 DOI:10.1055/a-2379-6849
Sana Ahmad, Farogh Ahsan, Javed Akhtar Ansari, Tarique Mahmood, Shahzadi Bano, Mo Shahanawaz
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引用次数: 0

摘要

生物类黄酮是一类种类繁多的植物营养素,广泛分布于水果、蔬菜、谷物、茶叶和某些药材中。它们具有抗氧化特性,在植物生物学中发挥着重要作用,如为花果增色、保护植物免受环境压力等。大豆黄酮(Daidzein)是一种生物类黄酮,归类于天然产品,来自大豆和豆类等植物。它以苷和苷醛等形式存在,其中等醇和三羟异黄酮是肠道细菌形成的主要代谢产物。麦角苷以其广泛的治疗潜力而闻名,对心血管健康、癌症、糖尿病、皮肤病、骨质疏松症和神经退行性疾病都有疗效。其作用机制包括与雌激素受体相互作用、抗氧化和抗炎特性以及调节细胞凋亡和细胞周期。本文对旨在提高地屈孕酮生物利用度和疗效的制剂技术的最新进展进行了批判性评估,包括基于纳米颗粒的给药系统和封装策略。研究人员已经开发出纳米颗粒和脂质体等先进配方,以提高麦地那龙血素的溶解度、稳定性、生物利用度和定向递送。作为一种前景广阔的营养保健品,要想充分发挥其临床潜力,还需要进一步研究其分子作用和安全性。这篇综述简明扼要地概述了其治疗功效、化学特性、历史用途、毒理学见解、给药系统的最新进展以及未来的研究方向。
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Bioflavonoid Daidzein: Therapeutic Insights, Formulation Advances, and Future Directions.

Bioflavonoids, are a diverse group of phytonutrients that are widely distributed in fruits, vegetables, grains, teas, and certain medicinal herbs. They are characterized by their antioxidant properties and play essential roles in plant biology, such as providing color to fruits and flowers, protecting plants from environmental stresses. Daidzein, a bioflavonoid classified under natural products, is sourced from plants like soybeans and legumes. It exists in forms such as glycosides and aglycones, with equol and trihydroxy isoflavone being key metabolites formed by gut bacteria. Known for its wide-ranging therapeutic potential, daidzein has shown effects on cardiovascular health, cancer, diabetes, skin conditions, osteoporosis, and neurodegenerative disorders. Its mechanisms include interaction with estrogen receptors, antioxidative and anti-inflammatory properties, and modulation of apoptosis and cell cycles. Recent advances in formulation technologies aimed at enhancing daidzein's bioavailability and efficacy are critically evaluated, including nanoparticle-based delivery systems and encapsulation strategies. Researchers have developed advanced formulations like nanoparticles and liposomes to enhance daidzein's solubility, stability, bioavailability, and targeted delivery. Considered a promising nutraceutical, daidzein warrants further exploration into its molecular actions and safety profile to fully realize its clinical potential. This review offers a succinct overview encompassing therapeutic benefits, chemical characteristics, historical uses, toxicology insights, recent advancements in delivery systems, and future directions for daidzein research.

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来源期刊
Drug Research
Drug Research PHARMACOLOGY & PHARMACY-
CiteScore
3.50
自引率
0.00%
发文量
67
期刊介绍: Drug Research (formerly Arzneimittelforschung) is an international peer-reviewed journal with expedited processing times presenting the very latest research results related to novel and established drug molecules and the evaluation of new drug development. A key focus of the publication is translational medicine and the application of biological discoveries in the development of drugs for use in the clinical environment. Articles and experimental data from across the field of drug research address not only the issue of drug discovery, but also the mathematical and statistical methods for evaluating results from industrial investigations and clinical trials. Publishing twelve times a year, Drug Research includes original research articles as well as reviews, commentaries and short communications in the following areas: analytics applied to clinical trials chemistry and biochemistry clinical and experimental pharmacology drug interactions efficacy testing pharmacodynamics pharmacokinetics teratology toxicology.
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